This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

In 1603, Queen Elizabeth I died and King James I inherited the English throne. During James's reign, England continued to hark back to Elizabeth, comparing him with his predecessor - not always in a way that was either flattering or pleasing to James. Critics have traditionally assumed that Shakespeare avoided involving himself in this discourse. In this study of Shakespeare's Jacobean plays, however, Yuichi Tsukada demonstrates that, far from not involving himself in the phenomenon of nostalgia for Elizabeth, Shakespeare interacted closely with retrospective writings on Elizabeth and illuminated the complex politics behind the nostalgia. Based upon close readings of Macbeth, Antony and Cleopatra, Coriolanus, Cymbeline and Henry VIII, together with a range of plays by Shakespeare's contemporaries, including Thomas Heywood, Thomas Dekker, George Chapman, John Marston, Thomas Middleton and Ben Jonson, the book traces the ongoing cultural negotiation of the memory of Elizabeth. Yuichi Tsukada offers fresh insights into enigmatic aspects of Shakespeare's Jacobean drama. For instance, what was the original significance of the two contentious prophecies - 'none of woman born' and the march of Birnam Wood - in Macbeth? Or that of the seemingly out-of-place triumphal procession of Volumnia near the tragic end of Coriolanus? Although her memory recurred in all forms of discourse throughout the first decade of James's reign, the impact of this cultural undercurrent on Shakespeare's Jacobean drama has been ignored or underestimated. Shakespeare and the Politics of Nostalgia reveals the unnoticed richness of Shakespeare's Jacobean drama by focusing on the growing cultural and political nostalgia for England's dead queen.

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

In 1603, Queen Elizabeth I died and King James I inherited the English throne. During James's reign, England continued to hark back to Elizabeth, comparing him with his predecessor - not always in a way that was either flattering or pleasing to James. Critics have traditionally assumed that Shakespeare avoided involving himself in this discourse. In this study of Shakespeare's Jacobean plays, however, Yuichi Tsukada demonstrates that, far from not involving himself in the phenomenon of nostalgia for Elizabeth, Shakespeare interacted closely with retrospective writings on Elizabeth and illuminated the complex politics behind the nostalgia. Based upon close readings of Macbeth, Antony and Cleopatra, Coriolanus, Cymbeline and Henry VIII, together with a range of plays by Shakespeare's contemporaries, including Thomas Heywood, Thomas Dekker, George Chapman, John Marston, Thomas Middleton and Ben Jonson, the book traces the ongoing cultural negotiation of the memory of Elizabeth. Yuichi Tsukada offers fresh insights into enigmatic aspects of Shakespeare's Jacobean drama. For instance, what was the original significance of the two contentious prophecies - 'none of woman born' and the march of Birnam Wood - in Macbeth? Or that of the seemingly out-of-place triumphal procession of Volumnia near the tragic end of Coriolanus? Although her memory recurred in all forms of discourse throughout the first decade of James's reign, the impact of this cultural undercurrent on Shakespeare's Jacobean drama has been ignored or underestimated. Shakespeare and the Politics of Nostalgia reveals the unnoticed richness of Shakespeare's Jacobean drama by focusing on the growing cultural and political nostalgia for England's dead queen.