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Cardiac performance is regulated not only by cardiac muscle
properties but also by several other factors, including those
associated with the neurohumoral system and the mechanical
characteristics of the peripheral circulation. New information con
cerning these regulatory factors has furthered our understanding of
the pathophysi ology of cardiac dysfunction. However, controversy
remains, along with a need to integrate these multidisciplinary
findings. It was with this in mind, together with my continuing
interest in the response of the normal and diseased heart to
variations in loading conditions, that the satellite symposium
entitled "Interactions Between Car diac Function and Vascular
Dynamics" was organized and dedicated to my mentor, Dr. T.
Takishima. The symposium was held in Fukushima, Japan, in 1992
following the Tenth Inter national Conference of the Cardiovascular
Systems Dynamics Society in Kobe, Japan, which was organized by the
then president of the society, Dr. Masatsugu Hori. The Fukushima
symposium and the Kobe conference were stimulating and informative.
To commemorate these events, Dr. Hori, Dr. Janicki, and I decided
to publish this book. It covers topics that were presented then as
well as pertinent new material. As a result, the book includes not
only updated reviews but also up-to-date findings that were not
considered at the two scientific sessions. The high level attained
in this book is due to the outstanding contributions from
internationally renowned scientists. This final product of their
efforts should prove to be a valuable source of information to the
reader.
Advances in cellular physiology and molecular biology have now
disclosed the metabolic changes and adaptational responses of the
heart to various kinds of stresses. Topics covered in this volume
include the regulation of myocardial proteins in mechanical
overload, the alteration of adrenoceptors in the stressed heart,
metabolic adaptation in cardiac hypertrophy, intracellular calcium
metabolism in the ischemia-reperfused myocardium, calcium overload
as a cause of myocardial stunning, acquisition of ischemic
tolerance by ischemic preconditioning, factors that accelerate
myocardial injury, and ventricular remodeling in the ischemic
heart. As an update of the latest findings in basic cardiology,
this book will benefit both researchers and clinical practitioners.
Advances in cellular physiology and molecular biology have now
disclosed the metabolic changes and adaptational responses of the
heart to various kinds of stresses. Topics covered in this volume
include the regulation of myocardial proteins in mechanical
overload, the alteration of adrenoceptors in the stressed heart,
metabolic adaptation in cardiac hypertrophy, intracellular calcium
metabolism in the ischemia-reperfused myocardium, calcium overload
as a cause of myocardial stunning, acquisition of ischemic
tolerance by ischemic preconditioning, factors that accelerate
myocardial injury, and ventricular remodeling in the ischemic
heart. As an update of the latest findings in basic cardiology,
this book will benefit both researchers and clinical practitioners.
Cardiac performance is regulated not only by cardiac muscle
properties but also by several other factors, including those
associated with the neurohumoral system and the mechanical
characteristics of the peripheral circulation. New information con
cerning these regulatory factors has furthered our understanding of
the pathophysi ology of cardiac dysfunction. However, controversy
remains, along with a need to integrate these multidisciplinary
findings. It was with this in mind, together with my continuing
interest in the response of the normal and diseased heart to
variations in loading conditions, that the satellite symposium
entitled "Interactions Between Car diac Function and Vascular
Dynamics" was organized and dedicated to my mentor, Dr. T.
Takishima. The symposium was held in Fukushima, Japan, in 1992
following the Tenth Inter national Conference of the Cardiovascular
Systems Dynamics Society in Kobe, Japan, which was organized by the
then president of the society, Dr. Masatsugu Hori. The Fukushima
symposium and the Kobe conference were stimulating and informative.
To commemorate these events, Dr. Hori, Dr. Janicki, and I decided
to publish this book. It covers topics that were presented then as
well as pertinent new material. As a result, the book includes not
only updated reviews but also up-to-date findings that were not
considered at the two scientific sessions. The high level attained
in this book is due to the outstanding contributions from
internationally renowned scientists. This final product of their
efforts should prove to be a valuable source of information to the
reader."
Coronary circulation research is advancing at a rapid rate. Not
only are inno vative techniques for studying myocardial perfusion
being developed, new mechanisms related to coronary blood flow
control and mechanics are also being discovered. The progress in
this field justifies an update in the form of this new monograph.
The book is divided into the following sections: "Measurement of
Coronary Blood Flow and Assessment of Myocardial Per fusion"
discusses advances in perfusion measurements in humans as well as
nonradioactive microsphere methods. . "Coronary Flow Dynamics"
elucidates the effect of heart contraction on coronary flow,
perfusion, and reserve distribution as well as systolic-diastolic
interaction. Models-a frequent topic of debate-are used to quantify
hypotheses. "Models of Coronary Circulation" attempts to elucidate
the concept of tissue pressure. "Regulatory Mechanisms of Coronary
circulation and its Clinical Relevance" N u.merous mechanisms
affecting coronary flow have been defined and studied at the level
of isolated vessels and whole organs. The chapters in this section
provide an in-depth analysis of a selection of these mechanisms and
their inter actions. "Pathophysiology of Coronary Circulation in
Ischemic Heart Disease" considers important aspects of factors
which restrict perfusion of the myocardium in ischemic heart
disease. An understanding these factors is of crucial importance in
the management of patients. "Small Vessel Disorder in Coronary
Circulation" describes circulatory flow and how it can be
influenced by drugs."
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