This volume contains the papers presented at the 14th International Conference on Information Processing in Medical Imaging. IPMI meetings have a a strong emphasis on the clinical relevance and validation of medical imaging. This book covers the whole spectrum: acquisition, tomographic reconstruction, registration, segmentation, knowledge-based analysis, display and image quality as well as several important applications. Several papers present significant advances in topics already discussed at previous meetings while others deal with new topics and methodology, opening new horizons in medical imaging. In addition to the 28 full-length papers, 30 short communications are included to sample the most current work in progress. Audience: An up-to-date and complete overview of ongoing research in medical imaging, beneficial to all physicists, computer scientists and physicians who wish to remain informed on state-of-the-art methodology in medical imaging.