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If you are a HR/line manager or seeking flexible working and
wanting guidance on what to expect, this book is for you. The book
covers: descriptions and suitability of the main types of flexible
working; the legal implications; the procedure for
requests,consideration and responses and permitted reasons for
refusal; and, advice on adopting a flexible working policy and
putting it into practice. In the Speed Read series: this book is
affordable and concise. It includes top tips, real life examples
from voluntary organisations, checklists to help decide on a
suitable policy and clear pointers to other sources of information.
This volume will address an important emergent area within the
field of immunomics: the discovery of antigens and adjuvants within
the context of reverse vaccinology. Conventional approaches to
vaccine design and development requires pathogens to be cultivated
in the laboratory and the immunogenic molecules within them to be
identifiable. Conventional vaccinology is no longer universally
successful, particularly for recalcitrant pathogens. By using
genomic information we can study vaccine development in silico:
'reverse vaccinology', can identify candidate subunits vaccines by
identifying antigenic proteins and by using equally rational
approaches to identify novel immune response-enhancing adjuvants.
The aim of this book is to present a range of analytical methods
that can be used in formulation design and development and focus on
how these systems can be applied to understand formulation
components and the dosage form these build. To effectively design
and exploit drug delivery systems, the underlying characteristic of
a dosage form must be understood--from the characteristics of the
individual formulation components, to how they act and interact
within the formulation, and finally, to how this formulation
responds in different biological environments. To achieve this,
there is a wide range of analytical techniques that can be adopted
to understand and elucidate the mechanics of drug delivery and drug
formulation. Such methods include e.g. spectroscopic analysis,
diffractometric analysis, thermal investigations, surface
analytical techniques, particle size analysis, rheological
techniques, methods to characterize drug stability and release, and
biological analysis in appropriate cell and animal models. Whilst
each of these methods can encompass a full research area in their
own right, formulation scientists must be able to effectively apply
these methods to the delivery system they are considering. The
information in this book is designed to support researchers in
their ability to fully characterize and analyze a range of delivery
systems, using an appropriate selection of analytical techniques.
Due to its consideration of regulatory approval, this book will
also be suitable for industrial researchers both at early stage up
to pre-clinical research.
A significant improvement in the safety of modern vaccines has been
the development of subunit vaccines, as these are composed of very
well-defined and highly pure components, often recombinant
proteins. However, since protein-based antigens in general are
weakly immunogenic by themselves, co-administration of adjuvants is
required to induce potent and persistent specific immune responses.
In recent years, there has been substantial progress in the
discovery of new efficient adjuvants for subunit vaccines that are
often classified into delivery systems and immunopotentiating
compounds that constitute pathogen-associated molecular patterns,
such as the toll-like receptor ligands. The combination of delivery
systems and immunopotentiators has appeared to represent
extraordinarily good adjuvants due to concomitant enhanced antigen
delivery and potent stimulation of innate immunity. Many of these
adjuvants are of a particulate nature and mimic the structure
and/or composition of microbes in a reductionist fashion. Examples
are liposomes, polymeric nanoparticles, emulsions and virus-like
particles. However, there are a substantial number of
pharmaceutical challenges associated with the subunit vaccine
development process due to the complex nature of the
antigen-adjuvant combinations. These challenges will be presented
and discussed in this book. The objective of the book is to compile
the concepts essential for the understanding of the pharmaceutical
science and technology associated with the delivery of subunit
vaccines. The books goal is to provide a comprehensive overview of
the scientific and regulatory challenges facing scientists who
research and develop subunit vaccines. The scope of the book is
wide. It is written in a manner that will enlighten newcomers to
the field (e.g., PhD students or experienced scientist switching
fields) yet provide an in-depth knowledge that would benefit a
skilled worker in the field. "
The aim of this book is to present a range of analytical methods
that can be used in formulation design and development and focus on
how these systems can be applied to understand formulation
components and the dosage form these build. To effectively design
and exploit drug delivery systems, the underlying characteristic of
a dosage form must be understood--from the characteristics of the
individual formulation components, to how they act and interact
within the formulation, and finally, to how this formulation
responds in different biological environments. To achieve this,
there is a wide range of analytical techniques that can be adopted
to understand and elucidate the mechanics of drug delivery and drug
formulation. Such methods include e.g. spectroscopic analysis,
diffractometric analysis, thermal investigations, surface
analytical techniques, particle size analysis, rheological
techniques, methods to characterize drug stability and release, and
biological analysis in appropriate cell and animal models. Whilst
each of these methods can encompass a full research area in their
own right, formulation scientists must be able to effectively apply
these methods to the delivery system they are considering. The
information in this book is designed to support researchers in
their ability to fully characterize and analyze a range of delivery
systems, using an appropriate selection of analytical techniques.
Due to its consideration of regulatory approval, this book will
also be suitable for industrial researchers both at early stage up
to pre-clinical research.
This comprehensive volume compiles the concepts essential for the
understanding of the pharmaceutical science and technology
associated with the delivery of subunit vaccines. Twenty-one
chapters are divided into four main parts: (I) Background; (2)
Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices
and Dosage Forms; and (4) Pharmaceutical Analysis and Quality
Control of Vaccines. Part one provide a basic background with
respect to immunology and general vaccine classification. In part
two, it presents representative types of vaccine delivery systems
individually with focus on the physicochemical properties of the
systems and their significance for the immune response they
stimulate. These delivery systems include aluminum adjuvants,
emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs,
virus-like particles, polymeric nano- and microparticles, gels,
implants and cell-based delivery systems. Following these chapters,
part three addresses the challenges associated with vaccine
delivery via specific routes of administration-in particular
subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal
and vaginal administration. Furthermore, the specific
administration routes are discussed in combination with device
technologies relevant for the respective routes as well as dosage
forms appropriate for the device technology. Finally, the fourth
part concerns pharmaceutical analysis and quality control of
subunit vaccines.
This volume will address an important emergent area within the
field of immunomics: the discovery of antigens and adjuvants within
the context of reverse vaccinology. Conventional approaches to
vaccine design and development requires pathogens to be cultivated
in the laboratory and the immunogenic molecules within them to be
identifiable. Conventional vaccinology is no longer universally
successful, particularly for recalcitrant pathogens. By using
genomic information we can study vaccine development in silico:
'reverse vaccinology', can identify candidate subunits vaccines by
identifying antigenic proteins and by using equally rational
approaches to identify novel immune response-enhancing adjuvants.
This guide is for those who know that the ostrich attitude leaves
talent untapped and that to be on the wrong side of the law is
expensive in time, money, relationships and reputation. The book
includes: the essentials of unlawful age discrimination as in the
2006 Regulations; advice on what to include in policy on age
discrimination; how to avoid age discrimination complaints; and,
guidance on how to turn policy into practice throughout your
organization. In the Speed Read series: this book is handy,
affordable and concise. It includes top tips, case studies and
clear signposts to other sources of information.
This "FASTtrack" book systematically reviews important concepts and
facts relating to the delivery and targeting of drugs. Relevant
examples of delivery systems are given throughout the book with a
focus on delivery systems that have actually reached clinical
reality.
You may be one of the millions of people who are spiritually
growing faster than your body can tolerate. What you are
experiencing is a normal response known as ascension symptoms.
Learn how to manage these symptoms and anchor your light body while
you help the Earth and others ascend. Shifting into Purer
Consciousness is astonishing in its breadth and depth of knowledge
in what it means to be a spirit being in human form at this
particular time. A truthful and candid a discussion of the human
condition and ascension consciousness. Within these pages, you will
discover that vital guidance to help you on your ascension path.
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Sweet Dream Makers (Paperback)
Dennis S Martin, Irene Brodsky, Yvonne Perry, Lora Mitchell, Jan Bossing, …
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R253
Discovery Miles 2 530
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Ships in 10 - 15 working days
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a collection of poetry about dreams
Ensuring competency in maths skills is a fundamental part of
pharmacy education as accurate pharmaceutical calculations are
crucial to the safe and effective use of drugs. This text combines
both the scientific calculations underpinning dosage forms with
calculations relating to pharmacy practice in a single resource. An
innovative student-centred approach is taken throughout the text,
with numerous worked examples and self-test questions to stimulate
self-directed learning. Frequent case studies highlight the
importance of maths to pharmacy, and help students to make that
crucial connection between theory and practice, while key take-home
messages for each section are summarised in concise learning-point
boxes. Written by leading academics with a wealth of experience in
pharmacy education Maths Skills for Pharmacy is the ideal textbook
for the subject. Online Resource Centre The Online Resource Centre
to accompany Maths Skills for Pharmacy features: For registered
adopters of the book: - Figures from the book, available to
download. For students:-Interactive multiple choice questions with
feedback keyed to the relevant section in the text -Short answer
questions with worked solutions
ARE YOU EMPATHIC? Are your coworkers, friends, and family members
like psychic vampires who siphon your energy and leave you feeling
drained? Feeling angry, depressed, or sick most of the time? You
may be an empath picking up on the detrimental thoughts, emotions,
and attitudes of others. Whose Stuff Is This? Finding Freedom from
the Thoughts, Feelings, and Energy of Those Around You is for those
who carry energetic burdens that belong to someone else. More than
two dozen proven and effective ways to clear your energy field,
this guide employs empowering, proactive techniques to manage your
own energy. With a chapter on the psychology of empathy by Dr.
Caron Goode, this book presents the personal story of how the
author learned to psychically protect herself. Shield yourself from
unwanted energy as you develop emotional intelligence Offer
compassion without paying a personal price Set boundaries and
detach from environmental stimuli including the energy of people
and entities Raise your vibration to a level that makes you
invisible to lower-vibrating energy A brilliant, much-needed
guidebook for children and adults whose gift of empathy can also be
their greatest challenge . . . excellent techniques to use this
gift of emotional connection in alignment with one's soul's
purpose. Devra Ann Jacobs, President, Dancing Word Group LLC A
comprehensive book for anyone interested in developing their
intuition and psychic abilities. Presented in an easy-to-read
manner, Yvonne has created an encyclopedia of knowledge pertaining
to the healing arts. Harriette Knight, author of CHAKRA POWER How
to Fire Up Your Energy Centers to Live a Fuller Life This book
should be required reading for all human beings as we continue to
learn how to navigate our energy bodies while being in a physical
body. With thorough research and case examples, the information on
setting boundaries is a must-read whether you consider yourself to
be an empath or not. Tisha Morris, author of 27 Things to Feng Shui
Your Home . . . an extensive library of answers that can help you
figure out what's going on while also empowering you to do
something about it Elise Lebeau, M.Sc., Professional Intuitive,
Founder of the EmpathCommunity.EliseLebeau.com
Frankie the Walk 'N Roll Dog keeps rolling along in her doggie
wheelchair. This paralyzed dachshund's unabashed healing, exuberant
spirit, and spunky personality is a blessed gift to everyone she
befriends. In this true, inspirational story, Frankie tells how she
became a registered therapy dog and shares her visits to Libby's
House, a senior facility where many residents have Alzheimer's or
dementia. Frankie teaches us that patience, listening, and
understanding opens our hearts to what matters most-love. With this
lovely book, Frankie will win your heart and inspire children to
overcome whatever obstacles they face in life. Told from Frankie's
viewpoint, this journey from using a wheelchair (dog cart) to
finding her purpose as a therapy dog is not only touching but also
shows children how much joy, healing, and hope a dog can bring to
this world. Outstanding! ~Linda and Allen Anderson, authors of
Angel Animals books www.angelanimals.net
More Than Meets the Eye shares true stories and sheds light on
euthanasia, suicide, near-death experience, hospice care and much
more. Spirit visits by a deceased loved one are very common and
show how we are still connected even after we leave the body
behind. You'll find comfort and peace about the mysterious process
of transitioning back to God/Source in this delightful exploration
into the unknown by an author who openly shares her soul. A welcome
blend of intrigue, courage and adventure, that will open your mind,
calm your spirit, alleviate your fear of death and lighten your
heart.
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