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th This volume contains selected lectures presented at the 12
International Conference on Advances in Prostaglandin, Leukotriene
and Other Bioactive Lipid Research: Basic Science and Clinical
Applications which was held in Istanbul, Turkey, on August 25-29,
2002. This meeting brought together basic and clinical scientists
for the purpose of discussing advances in bioactive lipid research
with.special attention to cancer, cardiovascular diseases,
gastrointestinal diseases and respiratory diseases. Topics covered
included: the role of leukotrienes and lipoxins in of inflammation,
the cytochrome P450 pathway, the genetics and genomics bioactive
lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes,
receptors and inhibitors, cyclooxygenase and lipoxygenase pathways
and inhibitors, prostaglandin synthases and receptor signaling,
phospholipases and inhibitors. Sessions included plenary lectures
with expertise in particular areas, oral presentation on selected
topics and general poster sessions. J.M. Drazen (Boston, USA)
discussed anti-leukotriene treatment in asthma patients while C.
Brink (paris, France) presented the recent advances in leukotriene
receptors. The recent advances in cytochrome p450 pathway described
in the session organized by J.C. McGiff (Valhalla, NY, USA). T.
Shimizu (Tokyo, Japan) and M. Balazy (Valhalla, NY, USA) gave an
update on phospholipases and arachidonic acid peroxydation. The
editors are greatful to the Organizing, Programme and Advisory
Committees for their valuable contributions. We greatfully
acknowledge the generous financial support provided by
PharmaciaIPfizer, Fako Pharmaceuticals Inc. and Novartis
Pharmaceuticals Inc. ofthe contributors to this volume, in
particular We are also greatful to all to those who delivered their
manuscripts by or before the requested deadline.
th This volume contains selected lectures presented at the 12
International Conference on Advances in Prostaglandin, Leukotriene
and Other Bioactive Lipid Research: Basic Science and Clinical
Applications which was held in Istanbul, Turkey, on August 25-29,
2002. This meeting brought together basic and clinical scientists
for the purpose of discussing advances in bioactive lipid research
with.special attention to cancer, cardiovascular diseases,
gastrointestinal diseases and respiratory diseases. Topics covered
included: the role of leukotrienes and lipoxins in of inflammation,
the cytochrome P450 pathway, the genetics and genomics bioactive
lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes,
receptors and inhibitors, cyclooxygenase and lipoxygenase pathways
and inhibitors, prostaglandin synthases and receptor signaling,
phospholipases and inhibitors. Sessions included plenary lectures
with expertise in particular areas, oral presentation on selected
topics and general poster sessions. J.M. Drazen (Boston, USA)
discussed anti-leukotriene treatment in asthma patients while C.
Brink (paris, France) presented the recent advances in leukotriene
receptors. The recent advances in cytochrome p450 pathway described
in the session organized by J.C. McGiff (Valhalla, NY, USA). T.
Shimizu (Tokyo, Japan) and M. Balazy (Valhalla, NY, USA) gave an
update on phospholipases and arachidonic acid peroxydation. The
editors are greatful to the Organizing, Programme and Advisory
Committees for their valuable contributions. We greatfully
acknowledge the generous financial support provided by
PharmaciaIPfizer, Fako Pharmaceuticals Inc. and Novartis
Pharmaceuticals Inc. ofthe contributors to this volume, in
particular We are also greatful to all to those who delivered their
manuscripts by or before the requested deadline.
Drug-drug interactions are causing morbidity and mortality in
mankind. Severe harmful interactions are recoded when drugs are
prescribed without studying their pharmacokinetic and
pharmacodynamic actions. Knowledge about drug interactions is
necessary for pharmaceutical industries, regulatory agencies,
clinical health care professionals and policy makers. The book
focuses on research findings regarding influence of Fluoroquinolone
(Ciprofloxacin) on the pharmacokinetics of Carbamazepine,
investigated in healthy adult males. Carbamazepine is mostly
prescribed drug for the treatment of epilepsy, neuropathic pain,
schizophrenia, phantom limb syndrome and paroxysmal extreme pain
disorder. Epileptic patients can have various types of infections
like urinary tract, upper respiratory tract, skin and soft tissue,
dental pain, typhoid and other infectious diseases. These patients
often injured during fits and fluoroquinolones are used as first
line of therapy to treat such kind of infectious disease. Since
both drugs are prescribed commonly by the physicians and
interaction may result, so the information about their
pharmacokinetics given here are beneficial for physicians and
researchers.
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