Comprehensive resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of "free data" available to today's pharmaceutical researchers. Throughout the text, the applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process. Contributed to and edited by experts with long-time experience in the field, Open Access Databases and Datasets for Drug Discovery includes information on: A comprehensive listing of open access databases and datasets for computer-aided drug design PubChem as a chemical database for drug discovery, DrugBank Online, and bioisosteric replacement for drug discovery supported by the SwissBioisostere database The Protein Data Bank (PDB) and macromolecular structure data supporting computer-aided drug design, and the SWISS-MODEL repository of 3D protein structures and models PDB-REDO in computational aided drug design (CADD), and mining for bioactive molecules in databases Unmatched in scope and comprehensively reviewing small and large open data sources relevant for rational drug design, Open Access Databases and Datasets for Drug Discovery is an essential reference for medicinal and pharmaceutical chemists, and any scientists involved in the drug discovery and drug development.

This is a new release of the original 1932 edition.

Leadership Revealed by Mike Adi and Sander De Zoete, is above and beyond what you hear and read about leadership. The six Elementals of leadership: Vision, Purpose, Identity, Values & Beliefs and Behaviors are the fundaments of leadership. The five leadership stages transforms you into the desired leader. Principled leadership is a concept that takes you on a journey of discoveries into the world of leadership, elegantly told as a story. Just sit back, relax and enjoy the ride.

Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!

Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!

The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars.Delve into what it was like to live during the eighteenth century by reading the first-hand accounts of everyday people, including city dwellers and farmers, businessmen and bankers, artisans and merchants, artists and their patrons, politicians and their constituents. Original texts make the American, French, and Industrial revolutions vividly contemporary.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++Harvard University Houghton LibraryN003431Signed at end: Zetes. Concerning conflicting claims on the West Coast of North America.London: printed for J. Debrett, 1790. 2],49, 1]p.; 8

Not so long ago Emilio Brentani was a promising young author. Now he is an insurance agent on the fast track to forty. He gains a new lease on life, though, when he falls for the young and gorgeous Angiolina-except that his angel just happens to be an unapologetic cheat. But what begins as a comedy of infatuated misunderstanding ends in tragedy, as Emilio's jealous persistence in his folly-against his friends' and devoted sister's advice, and even his own best knowledge-leads to the loss of the one person who, too late, he realizes he truly loves. Marked by deep humanity and earthy humor, by psychological insight and an elegant simplicity of style, "As a Man Grows Older" ("Senilita," in Italian; the English title was the suggestion of Svevo's great friend and admirer, James Joyce) is a brilliant study of hopeless love and hapless indecision. It is a masterwork of Italian literature, here beautifully rendered into English in Beryl de Zoete's classic translation.

Not so long ago Emilio Brentani was a promising young author. Now he is an insurance agent on the fast track to forty. He gains a new lease on life, though, when he falls for the young and gorgeous Angiolina-except that his angel just happens to be an unapologetic cheat. But what begins as a comedy of infatuated misunderstanding ends in tragedy, as Emilio's jealous persistence in his folly-against his friends' and devoted sister's advice, and even his own best knowledge-leads to the loss of the one person who, too late, he realizes he truly loves. Marked by deep humanity and earthy humor, by psychological insight and an elegant simplicity of style, "As a Man Grows Older" ("Senilita," in Italian; the English title was the suggestion of Svevo's great friend and admirer, James Joyce) is a brilliant study of hopeless love and hapless indecision. It is a masterwork of Italian literature, here beautifully rendered into English in Beryl de Zoete's classic translation.

'I am sure a cigarette has a more poignant flavour when it is the last' A neurotic Italian businessman obsessed by his own hypochondria, Zeno Cosini recounts his early years to his psychoanalyst Dr S as a form of therapy. With a cigarette clutched permanently between his fingers, he explores the important themes of his life: his love of smoking, his relationship with his parents, his marriage. Structured as a series of conversations with his psychoanalyst, Zeno was an innovation in its time, and remains a curious and intriguing delight. Michael Hoffman places Confessions of Zeno in its European context in his sparkling introduction.