explains in detail how extracellular vesicles are produced, endocytosed, and the mechanisms by which molecules play biological roles in the treatment of various diseases.

This book investigates the cloud-based techniques of content distribution mainly for mobile Internet. It starts with hot topics such as cellular traffic optimization and video content delivery. By integrating the cloud scheme, it further tackles issues of traffic-saving, energy-efficient, high-speed, and delay-tolerant content delivery with regard to mobile Internet. It covers both theoretical algorithms and their real-world system implementations. In particular, various well-known cloud platforms such as Baidu Traffic Guard, Tencent QQXuanfeng, Google Drive, Microsoft OneDrive, and Dropbox are elaborated respectively in the book. Lastly, it includes an educational and experimental cloud computing platform allowing public access, which benefits researchers, practitioners, and developers in the field of cloud computing/storage and mobile Internet. Throughout the book there are helpful and practical tips on setting up cloud systems that readers can easily follow.

This book constitutes the refereed proceedings of the 6th International Symposium on Intelligence Computation and Applications, ISICA 2012, held in Wuhan, China, in October 2012. The 72 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on artificial life, adaptive behavior, agents, and ant colony optimization; combinatorial and numerical optimization; communications and computer networks; data mining; evolutionary multi-objective and dynamic optimization; intelligent computation, intelligent learning systems; neural networks; real-world applications.

VolumesofLNCS 5821andCCIS51aretheproceedingsofthe 4thInternational Symposium on Intelligence Computation and Applications (ISICA 2009) held in Huangshi, China, October 23-25, 2009. These two volumes are in memory of Prof. Lishan Kang, the ISICA 2009 Honorary General Chair, who was a leading ?gurein the ?elds of domain decomposition methods and computational intelligence. ISICA 2009 successfully attracted over 300 submissions. Through rigorous reviews, 58 high-quality papers were included in LNCS 5821, while the other 54 papers were collected in CCIS 51. ISICA conferencesare one of the ?rst series of internationalconferencesoncomputationalintelligencethatcombineelementsof learning, adaptation, evolution and fuzzy logic to create programsas alternative solutions to arti?cial intelligence. The last three ISICA proceedings have been accepted in the Index to Scienti?c and Technical Proceedings (ISTP) and/or Engineering Information (EI). Following the success of the past three ISICA events, ISICA 2009 made good progress in the analysis and design of newly developed methods in the ?eld of computationalintelligence. ISICA 2009featured the most up-to-dateresearchin analysisandtheoryofevolutionaryalgorithms,neuralnetworkarchitecturesand learning, fuzzy logic and control, predictive modeling for robust classi?cation, swarm intelligence, evolutionary system design, evolutionary image analysis and signal processing, and computational intelligence in engineering design. ISICA 2009 provided a venue to foster technical exchanges, renew everlasting frie- ships, and establish new connections.

VolumesofLNCS 5821andCCIS51aretheproceedingsofthe 4thInternational Symposium on Intelligence Computation and Applications (ISICA 2009) held in Huangshi, China, October 23-25, 2009. These two volumes are in memory of Prof. Lishan Kang, the ISICA 2009 Honorary General Chair, who was a leading ?gurein the ?elds of domain decomposition methods and computational intelligence. ISICA 2009 successfully attracted over 300 submissions. Through rigorous reviews, 58 high-quality papers were included in LNCS 5821, while the other 54 papers were collected in CCIS 51. ISICA conferencesare one of the ?rst series of internationalconferencesoncomputationalintelligencethatcombineelementsof learning, adaptation, evolution and fuzzy logic to create programsas alternative solutions to arti?cial intelligence. The last three ISICA proceedings have been accepted in the Index to Scienti?c and Technical Proceedings (ISTP) and/or Engineering Information (EI). Following the success of the past three ISICA events, ISICA 2009 made good progress in the analysis and design of newly developed methods in the ?eld of computationalintelligence. ISICA 2009featured the most up-to-dateresearchin analysisandtheoryofevolutionaryalgorithms, neuralnetworkarchitecturesand learning, fuzzy logic and control, predictive modeling for robust classi?cation, swarm intelligence, evolutionary system design, evolutionary image analysis and signal processing, and computational intelligence in engineering design. ISICA 2009 provided a venue to foster technical exchanges, renew everlasting frie- ships, and establish new connections

Content distribution, i.e., distributing digital content from one node to another node or multiple nodes, is the most fundamental function of the Internet. Since Amazon's launch of EC2 in 2006 and Apple's release of the iPhone in 2007, Internet content distribution has shown a strong trend toward polarization. On the one hand, considerable investments have been made in creating heavyweight, integrated data centers ("heavy-cloud") all over the world, in order to achieve economies of scale and high flexibility/efficiency of content distribution. On the other hand, end-user devices ("light-end") have become increasingly lightweight, mobile and heterogeneous, creating new demands concerning traffic usage, energy consumption, bandwidth, latency, reliability, and/or the security of content distribution. Based on comprehensive real-world measurements at scale, we observe that existing content distribution techniques often perform poorly under the abovementioned new circumstances. Motivated by the trend of "heavy-cloud vs. light-end," this book is dedicated to uncovering the root causes of today's mobile networking problems and designing innovative cloud-based solutions to practically address such problems. Our work has produced not only academic papers published in prestigious conference proceedings like SIGCOMM, NSDI, MobiCom and MobiSys, but also concrete effects on industrial systems such as Xiaomi Mobile, MIUI OS, Tencent App Store, Baidu PhoneGuard, and WiFi.com. A series of practical takeaways and easy-to-follow testimonials are provided to researchers and practitioners working in mobile networking and cloud computing. In addition, we have released as much code and data used in our research as possible to benefit the community.