This second edition of Reese and Van Impe's book has been extensively revised to be compatible in the classroom setting. New features include homework problems with solution aides presented by the student version of the software as well as new case studies and updated existing case studies that agree with modern methods of characterizing soil properties. The thrust of the book is a detailed presentation of methods of analysis for single piles and groups of piles under lateral loading. The method makes use of load-transfer functions that are based heavily on testing results of full-scale, heavily instrumented piles under carefully controlled lateral loading, coupled with the use of soil-structured interaction mechanics. This method is validated by comparing the results from the method of analysis with experimental results from case studies of un-instrumented piles. The book specifically addresses the analysis of piles of varying stiffness installed into soils with a variety of characteristics, accounting for the axial load at the top of the pile and for the rotational restraint of the pile head, possibly nonlinear, offered by the connection to the superstructure. The text provides example designs as well as the design of pile foundations that support an offshore platform. The book also includes references to a rich body of technical material, including citations of hundreds of relevant publications. The user may find the material on pile groups under lateral loading to be particularly helpful. The method begins with the loading at the foundation origin and makes use of nonlinear pile-head functions for the lateral load, the axial load, and the moment, taking pile-soil-pile interaction into account. For two-dimensional cases, the rotation and displacement of the foundation origin is computed to achieve equilibrium, and the resulting pile-head loading may be computed. Results for different loadings can also be readily calculated to seek t

Mayo Clinic Essential Neurology covers the full scope of neurology by combining a focused need-to-know format with core basics along with diagnosis and treatment guidelines. More than 75 color illustrations and numerous therapeutic tables help residents and clinicians diagnose, treat, and manage the most commonly encountered neurologic problems. Topics include: The neurologic examination Diagnostic tests Headache Spine and limb pain Dizziness Sensory loss and paresthesias Weakness Cognitive loss Spells Pain Cerebrovascular disease Movement disorders Immune and infectious diseases Neuro-oncology With coverage comprehensive enough for the practicing physician, the clear format also makes it the perfect introduction for medical students. A full-color guide to the essentials of neurology, this volume provides one of the most focused presentations in the field today.

Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.

Explores scientific and regulatory issues within the framework of a program for the management of toxic substances. Covers all major elements of toxic handling and treatment/disposal. Includes listings of government agency contacts, hotline, reporting, and regulated toxics. Intended for environmenta

Written by a team of experts, Advances in Flowmeter Technology surveys the full range of modern flowmeters for product managers, strategic planners, engineers, distributors, and students. The origins, principles of operation,controls and instrumentation, and the relative advantages of each major flowmeter type are thoroughly explained. Extensive coverage of new types that employ cutting-edge technologies - such as coriolis, magnetic, ultrasonic, vortex, thermal flowmeters - is provided. The text includes comparative examples, placing these new types of meters in the context of more traditional ones, such as differential pressure, turbine, and positive displacement flowmeters.

Energy and power are fundamental concepts in electromagnetism and circuit theory, as well as in optics, signal processing, power engineering, electrical machines, and power electronics. However, in crossing the disciplinary borders, we encounter understanding difficulties due to (1) the many possible mathematical representations of the same physical objects, and (2) the many possible physical interpretations of the same mathematical entities. The monograph proposes a quantum and a relativistic approach to electromagnetic power theory that is based on recent advances in physics and mathematics. The book takes a fresh look at old debates related to the significance of the Poynting theorem and the interpretation of reactive power. Reformulated in the mathematical language of geometric algebra, the new expression of electromagnetic power reflects the laws of conservation of energy-momentum in fields and circuits. The monograph offers a mathematically consistent and a physically coherent interpretation of the power concept and of the mechanism of power transmission at the subatomic (mesoscopic) level. The monograph proves (paraphrasing Heaviside) that there is no finality in the development of a vibrant discipline: power theory.

Reliability, Risk and Safety: Back to the Future covers topics on reliability, risk and safety issues, including risk and reliability analysis methods, maintenance optimization, human factors, and risk management. The application areas range from nuclear engineering, oil and gas industry, electrical and civil engineering to information technology and communication, security, transportation, health and medicine or critical infrastructures. Significant attention is paid to societal factors influencing the use of reliability and risk assessment methods, and to combinatorial analysis, which has found its way into the analysis of probabilities and risk, from which quantified risk analysis developed. Integral demonstrations of the use of risk analysis and safety assessment are provided in many practical applications concerning major technological systems and structures. Reliability, Risk and Safety: Back to the Future will be of interest to academics and engineers interested in nuclear engineering, oil and gas engineering, electrical engineering, civil engineering, information technology, communication, and infrastructure.

First published in 1986: The Purpose of this book is to provide working managers with a comprehensive introduction to practical operational aspects of hazardous waste management and with an extremely important foundation in relevant laws, rules and regulations.

Comprises four parts, the first of which provides an overview of the topics that are developed from fundamental principles to more advanced levels in the other parts. Presents in the second part an in-depth introduction to the relevant background in molecular and cellular biology and in physical chemistry, which should be particularly useful for students without a formal background in these subjects. Provides in the third part a detailed treatment of microscopy techniques and optics, again starting from basic principles. Introduces in the fourth part modern statistical approaches to the determination of parameters of interest from microscopy data, in particular data generated by single molecule microscopy experiments. Uses two topics related to protein trafficking (transferrin trafficking and FcRn-mediated antibody trafficking) throughout the text to motivate and illustrate microscopy techniques

Advances in thermal and non-thermal food processing aims to discuss emerging trends based on the future scope and challenges and to explain uncertain challenges in food processing. In thermal processing different operations in food engineering namely advance drying methods, evaporation, extrusion cooking, different extraction techniques, crystallizations are covered in terms food engineering and process modeling aspect. For non-thermal processing, high pressure processing, ultrasound, ohmic heating, pulse electric field, pulse light technology, osmotic dehydration and so forth are discussed. Relevant mathematical modeling and numerical simulations has been included in every chapter. Features: Presents engineering focus on thermal and non-thermal food processing technologies. Discusses sub-classification for recent trends and relevant industry information/examples. Describes advances in drying, evaporation, blanching, crystallization and ohmic heating. Covers high-pressure processing, pulse electric field, pulse light technology, irradiation, and ultrasonic techniques. Includes mathematical modeling and numerical simulations. The book is aimed at graduate students, professionals in food engineering and food technology, biological systems engineering.

The Handbook of Polyhydroxyalkanoates (PHA) focusses on and addresses varying facets of PHA biosynthesis and processing, spread across three volumes. The first volume discusses feedstock aspects, enzymology, metabolism and genetic engineering of PHA biosynthesis. It addresses better understanding the mechanisms of PHA biosynthesis in scientific terms and profiting from this understanding in order to enhance PHA biosynthesis in bio-technological terms and in terms of PHA microstructure. It further discusses making PHA competitive for outperforming established petrol-based plastics on industrial scale and obstacles for market penetration of PHA. This second volume focusses on thermodynamic and mathematical considerations of PHA biosynthesis, bioengineering aspects regarding bioreactor design and downstream processing for PHA recovery from microbial biomass. It covers microbial mixed culture processes and includes a strong industry-focused section with chapters on the economics of PHA production, industrial-scale PHA production from sucrose, next generation industrial biotechnology approaches for PHA production based on novel robust production strains, and holistic techno-economic and sustainability considerations on PHA manufacturing. Third volume is on the production of functionalized PHA bio-polyesters, the post-synthetic modification of PHA, processing and additive manufacturing of PHA, development and properties of PHA-based (bio)composites and blends, the market potential of PHA and follow-up materials, different bulk- and niche applications of PHA, and the fate and use of spent PHA items. Divided into fourteen chapters, it describes functionalized PHA and PHA modification, processing and their application including degradation of spent PHA-based products and fate of these bio-polyesters during compositing and other disposal strategies. Aimed at professionals and graduate students in Polymer (plastic) industry, wastewater treatment plants, food industry, biodiesel industry, this set: Presents comprehensive and holistic consideration of these microbial bioplastics in the volumes. Enables reader to learn about microbiological, enzymatic, genetic, synthetic biology, and metabolic aspects of PHA biosynthesis based on the latest scientific discoveries. Discusses design and operate a PHA production plant. Strong focus on post-synthetic modification, preparation of functional PHA and follow-up products, and PHA processing. Covers all related engineering considerations

Programmable logic controllers (PLCs) have been used extensively and are offered in terms of functions, program memories, and the number of inputs/outputs (I/Os), ranging from a few to thousands. With a focus on how to design and implement a PLC, this set explains hardware and associated basic concepts, intermediary and advanced concepts of PLC (using PIC16F1847 microcontroller). Flowcharts are provided to help the understanding of macros (instructions). Twenty application examples to show how to use the PIC16F1847-Based PLC in different control applications, related files for hardware and software components, and appendices are also provided. Aimed at researchers and graduate students in electrical engineering, power electronics, robotics and automation, sensors, this book: Explains how to design and use a PIC16F1847 microcontroller-based PLC including easy to use software structures. Covers concepts like Contact and Relay Based Macros, Flip-Flop Macros, Timer Macros, Counter Macros and Comparison Macros. Presents arithmetical and logical macros to carry out arithmetical and logical operations to be used for 8-bit or 16-bit variables and/or constant values. Illustrates program control macros to enable or disable a block of PLC program or to move execution of a program from one place to another. Discusses the implementation of Sequential Function Chart (SFC) elements with up to 24 steps.

The Big Book of Blob Feelings uses questions linked to specially selected, photocopiable pictures to help you explore feelings with those who struggle to communicate about their emotions. Tried, tested and loved internationally, this inspirational resource includes a wealth of material around: Blob Theory - the feelosophy, our open-question approach and the importance of allowing people to express their choices freely; Emotions - every day we all experience a wide range of feelings, a broad selection of which have been illustrated to kick-start discussions; Developmental issues - the objective of each of the sheets is to see people of all ages grow in their awareness of who they are, their uniqueness, and how they can develop those gifts further as they share with others. Each picture is accompanied by ideas and questions to kick-start class, group or one-to-one discussion so that everything in the book is relevant to your needs in your setting. The complete book is also included electronically on the accompanying downloadable resources so that you can print and re-use resources as often as you need to. The perfect companion to this book is The Big Book of Blob Feelings 2, which provides a huge range of new material while following the same structure and approach.

Provides better understanding of Persistent Organic Pollutants (POPs) and how they affect humans and ecosystems. Includes genesis, categories, environmental fate and behaviour, and associated hazards. Reviews analytical techniques involved in detection, human exposure and management. Discusses environmental dynamics of POPs. Focus is on the comprehensive account of PCDD/Fs, PCBs, and PAH; other organochlorine POPs such as DDT, lindane, and dieldrin.

A Practical Guide from Top-Level Industry Scientists As advanced teaching and training in the development of cementitious materials increase, the need has emerged for an up-to-date practical guide to the field suitable for graduate students and junior and general practitioners. Get the Best Use of Different Techniques and Interpretations of the Results This edited volume provides the cement science community with a state-of-the-art overview of analytical techniques used in cement chemistry to study the hydration and microstructure of cements. Each chapter focuses on a specific technique, not only describing the basic principles behind the technique, but also providing essential, practical details on its application to the study of cement hydration. Each chapter sets out present best practice, and draws attention to the limitations and potential experimental pitfalls of the technique. Databases that supply examples and that support the analysis and interpretation of the experimental results strengthen a very valuable ready reference. Utilizing the day-to-day experience of practical experts in the field, this book: Covers sample preparation issues Discusses commonly used techniques for identifying and quantifying the phases making up cementitious materials (X-ray diffraction and thermogravimetric analysis) Presents good practice oncalorimetry and chemical shrinkage methods for studying cement hydration kinetics Examines two different applications of nuclear magnetic resonance (solid state NMR and proton relaxometry) Takes a look at electron microscopy, the preeminent microstructural characterization technique for cementitious materials Explains how to use and interpret mercury intrusion porosimetry Details techniques for powder characterization of cementitious materials Outlines the practical application of phase diagrams for hydrated cements Avoid common pitfalls by using A Practical Guide to Microstructural Analysis of Cementitious Materials. A one-of-a-kind reference providing the do's and don'ts of cement chemistry, the book presents the latest research and development of characterisation techniques for cementitious materials, and serves as an invaluable resource for practicing professionals specializing in cement and concrete materials and other areas of cement and concrete technology.

This textbook provides complete coverage of discrete-time financial models that form the cornerstones of financial derivative pricing theory. Unlike similar texts in the field, this one presents multiple problem-solving approaches, linking related comprehensive techniques for pricing different types of financial derivatives. Key features: In-depth coverage of discrete-time theory and methodology. Numerous, fully worked out examples and exercises in every chapter. Mathematically rigorous and consistent yet bridging various basic and more advanced concepts. Judicious balance of financial theory, mathematical, and computational methods. Guide to Material. This revision contains: Almost 200 pages worth of new material in all chapters. A new chapter on elementary probability theory. An expanded the set of solved problems and additional exercises. Answers to all exercises. This book is a comprehensive, self-contained, and unified treatment of the main theory and application of mathematical methods behind modern-day financial mathematics. Table of Contents List of Figures and Tables Preface I Introduction to Pricing and Management of Financial Securities 1 Mathematics of Compounding 2 Primer on Pricing Risky Securities 3 Portfolio Management 4 Primer on Derivative Securities II Discrete-Time Modelling 5 Single-Period Arrow–Debreu Models 6 Introduction to Discrete-Time Stochastic Calculus 7 Replication and Pricing in the Binomial Tree Model 8 General Multi-Asset Multi-Period Model Appendices A Elementary Probability Theory B Glossary of Symbols and Abbreviations C Answers and Hints to Exercises References Index Biographies Giuseppe Campolieti is Professor of Mathematics at Wilfrid Laurier University in Waterloo, Canada. He has been Natural Sciences and Engineering Research Council postdoctoral research fellow and university research fellow at the University of Toronto. In 1998, he joined the Masters in Mathematical Finance as an instructor and later as an adjunct professor in financial mathematics until 2002. Dr. Campolieti also founded a financial software and consulting company in 1998. He joined Laurier in 2002 as Associate Professor of Mathematics and as SHARCNET Chair in Financial Mathematics. Roman N. Makarov is Associate Professor and Chair of Mathematics at Wilfrid Laurier University. Prior to joining Laurier in 2003, he was an Assistant Professor of Mathematics at Siberian State University of Telecommunications and Informatics and a senior research fellow at the Laboratory of Monte Carlo Methods at the Institute of Computational Mathematics and Mathematical Geophysics in Novosibirsk, Russia.

This book describes methods for statistical brain imaging data analysis from both the perspective of methodology and from the standpoint of application for software implementation in neuroscience research. These include those both commonly used (traditional established) and state of the art methods. The former is easier to do due to the availability of appropriate software. To understand the methods it is necessary to have some mathematical knowledge which is explained in the book with the help of figures and descriptions of the theory behind the software. In addition, the book includes numerical examples to guide readers on the working of existing popular software. The use of mathematics is reduced and simplified for non-experts using established methods, which also helps in avoiding mistakes in application and interpretation. Finally, the book enables the reader to understand and conceptualize the overall flow of brain imaging data analysis, particularly for statisticians and data-scientists unfamiliar with this area. The state of the art method described in the book has a multivariate approach developed by the authors' team. Since brain imaging data, generally, has a highly correlated and complex structure with large amounts of data, categorized into big data, the multivariate approach can be used as dimension reduction by following the application of statistical methods. The R package for most of the methods described is provided in the book. Understanding the background theory is helpful in implementing the software for original and creative applications and for an unbiased interpretation of the output. The book also explains new methods in a conceptual manner. These methodologies and packages are commonly applied in life science data analysis. Advanced methods to obtain novel insights are introduced, thereby encouraging the development of new methods and applications for research into medicine as a neuroscience.

This fascinating book gives readers an appreciation of how biomedical research should work and how the reality is all too often seriously flawed. Explaining the logical basis of the different research approaches used by biomedical research scientists and their relative merits, it will help readers to make more realistic appraisal of media reports linking aspects of lifestyle, environment or diet to health outcomes and thus judge whether such claims are a real effect worthy of consideration for behavior change or deserving of further research resources. Key features: increases awareness of research fraud and some of the characteristics of fraudulent science and scientific fraudsters shows that whilst outright fraud may be uncommon, fudging of results to help achieve statistical significance may be more prevalent incorporates real-life case studies highlighting some of the infamous cases of research fraud and major scientific mistakes and the impact that they have had provides a convenient overview of the research process in the biomedical sciences, with a focus on research strategy rather than individual methods find supplemental detail on the author's blog https://drgeoffnutrition.wordpress.com/about/ By raising awareness of the possibility that research data may have been dishonestly generated and outlining some of the signs and symptoms that might suggest data fabrication, Error and Fraud: The Dark Side of Biomedical Research will help students and researchers to identify the strengths and limitations of different research approaches and allow them to make a realistic evaluations of their own and others' research findings.

Geotechnical Aspects of Underground Construction in Soft Ground comprises a collection of 112 papers, the Fujita Lecture, three Special Lectures and the Bright Spark Lecture presented at the Tenth International Symposium on Geotechnical Aspects of Underground Construction in Soft Ground, held in Cambridge, United Kingdom, 27-29 June 2022. This second edition includes four general reports on the symposium themes. The symposium is the latest in a series which began in New Delhi in 1994, and was followed by symposia in London (1996), Tokyo (1999), Toulouse (2002), Amsterdam (2005), Shanghai (2008), Rome (2011), Seoul (2014) and Sao Paulo (2017). This was organised by the Geotechnical Research Group at the University of Cambridge, under the auspices of the Technical Committee TC204 of the International Society for Soil Mechanics and Geotechnical Engineering (ISSMGE). Geotechnical Aspects of Underground Construction in Soft Ground includes contributions from more than 25 countries on research, design and construction of underground works in soft ground. The contributions cover: Field case studies Sensing technologies and monitoring for underground construction in soft ground Physical and numerical modelling of tunnels and deep excavations in soft ground Seismic response of underground infrastructure in soft ground Design and application of ground improvement for underground construction Ground movements, interaction with existing structures and mitigation measures The general reports give an overview of the papers submitted to the symposium, covered in four technical sessions. The proceedings include the written version of the five invited lectures covering topics ranging from developments in geotechnical aspects of underground construction, tunnelling and groundwater interaction (short and long-term effects), the influence of earth pressure balance shield tunnelling on pre-convergence and segmental liner loading (field observations, modelling and implications on design). Similar to previous editions, Geotechnical Aspects of Underground Construction in Soft Ground represents a valuable source of reference on the current practice of analysis, design, and construction of tunnels and deep excavations in soft ground. The book is particularly aimed at academics and professionals interested in geotechnical and underground engineering.

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

This book examines the life of the Australian artist Harry Reade (1927-1998) and his largely overlooked contribution to animation. It constitutes a biography of Reade, tracing his life from his birth to his period of involvement with animation between 1956 and 1969. It explores the forces that shaped Reade and chronicles his experiences as a child, his early working life, the influence of left-wing ideology on his creative development, his introduction to animation through the small but radical Waterside Workers' Federation Film Unit (WWFFU), and the influence he had on the development of Cuban animation as an educational tool of the Revolution. Key Features The text offers an alternative framework for considering the political, social, and cultural themes that characterised 1950s Australia and 1960s Cuba. A rare look into the cultural heritage of labor organizations and the populist power of animation to stimulate radical social consciousness. The book also crosses a range of intellectual disciplines, including Animation Studies, Art History, Cinema Studies, and the Social and Political Histories of Australia and Cuba. Max Bannah lives on Queensland's Sunshine Coast. Between 1976 and 2010, he worked in Brisbane as an animator producing television commercials, short films, and cartoon graphics. He also lectured in Animation History and Practice and Drawing for Animation at the Queensland University of Technology where, in 2007, he completed his Masters by Research thesis, "A Cause for Animation: Harry Reade and the Cuban Revolution."

Focused on the latest mobile technologies, this book addresses specific features (such as IoT) and their adoptions that aim to enable excellence in business in Industry 4.0. Furthermore, this book explores how the adoption of these technologies is related to rising concerns about privacy and trusted communication issues that concern management and leaders of business organizations. Managing IoT and Mobile Technologies with Innovation, Trust, and Sustainable Computing not only targets IT experts and drills down on the technical issues but also provides readers from various groups with a well-linked concept about how the latest trends of mobile technologies are closely related to daily living and the workplace at managerial and even individual levels.

This volume reviews the historical roots and theoretical foundations of biological systematics in an approachable text. The author outlines the structure and main tasks of systematics. Conceptual history is characterized as a succession of scientific revolutions. The philosophical foundations of systematic research are briefly reviewed as well as the structure and content of taxonomic theories. Most important research programs in systematics are outlined. The book includes analysis of the principal problematic issues as "scientific puzzles" in systematics. This volume is intended for professional taxonomists, biologists of various specialties, students, as well as all those interested in the history and theory of biology and natural sciences. Key Features Considers the conceptual history of systematics as the framework of evolutionary epistemology Builds a hierarchically organized quasi-axiomatic system of taxonomic theory Contends that more reductionist taxonomic concepts are less objective Supports taxonomic pluralism by non-classic philosophy of science as a normal condition of systematics Documents that "taxonomic puzzles" result from conflict between monistic and pluralistic attitudes Related Titles de Queiroz, K. et al., eds. Phylonyms: A Companion to the PhyloCode (ISBN 978-1-1383-3293-5) Sigwart, J. D. What Species Mean: A User's Guide to the Units of Biodiversity (ISBN 978-1-4987-9937-9) Rieppel, O. Phylogenetic Systematics: Haeckel to Hennig (ISBN 978-1-4987-5488-0) Wilkins, J. S. Species: The Evolution of the Idea, 2nd ed. (ISBN 978-1-1380-5574-2)