Concentrating on techniques for the detection and measurement of radioactivity, this book offers a guide to selecting the type of counter, type of source sample, duration for which the counting must be made, and the radiation emitted by the isotope for its efficient detection. It introduces a novel concept to explain not only the decay processes but also the selection of counting procedures for detecting and measuring radioactivity. The author builds up the foundation from the nature of the interaction of radiation with matter. He also highlights the differences between an ordinary chemical laboratory and a radiochemical one.

This second edition of Reese and Van Impe's book has been extensively revised to be compatible in the classroom setting. New features include homework problems with solution aides presented by the student version of the software as well as new case studies and updated existing case studies that agree with modern methods of characterizing soil properties. The thrust of the book is a detailed presentation of methods of analysis for single piles and groups of piles under lateral loading. The method makes use of load-transfer functions that are based heavily on testing results of full-scale, heavily instrumented piles under carefully controlled lateral loading, coupled with the use of soil-structured interaction mechanics. This method is validated by comparing the results from the method of analysis with experimental results from case studies of un-instrumented piles. The book specifically addresses the analysis of piles of varying stiffness installed into soils with a variety of characteristics, accounting for the axial load at the top of the pile and for the rotational restraint of the pile head, possibly nonlinear, offered by the connection to the superstructure. The text provides example designs as well as the design of pile foundations that support an offshore platform. The book also includes references to a rich body of technical material, including citations of hundreds of relevant publications. The user may find the material on pile groups under lateral loading to be particularly helpful. The method begins with the loading at the foundation origin and makes use of nonlinear pile-head functions for the lateral load, the axial load, and the moment, taking pile-soil-pile interaction into account. For two-dimensional cases, the rotation and displacement of the foundation origin is computed to achieve equilibrium, and the resulting pile-head loading may be computed. Results for different loadings can also be readily calculated to seek t

Mayo Clinic Essential Neurology covers the full scope of neurology by combining a focused need-to-know format with core basics along with diagnosis and treatment guidelines. More than 75 color illustrations and numerous therapeutic tables help residents and clinicians diagnose, treat, and manage the most commonly encountered neurologic problems. Topics include: The neurologic examination Diagnostic tests Headache Spine and limb pain Dizziness Sensory loss and paresthesias Weakness Cognitive loss Spells Pain Cerebrovascular disease Movement disorders Immune and infectious diseases Neuro-oncology With coverage comprehensive enough for the practicing physician, the clear format also makes it the perfect introduction for medical students. A full-color guide to the essentials of neurology, this volume provides one of the most focused presentations in the field today.

Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.

Explores scientific and regulatory issues within the framework of a program for the management of toxic substances. Covers all major elements of toxic handling and treatment/disposal. Includes listings of government agency contacts, hotline, reporting, and regulated toxics. Intended for environmenta

Written by a team of experts, Advances in Flowmeter Technology surveys the full range of modern flowmeters for product managers, strategic planners, engineers, distributors, and students. The origins, principles of operation,controls and instrumentation, and the relative advantages of each major flowmeter type are thoroughly explained. Extensive coverage of new types that employ cutting-edge technologies - such as coriolis, magnetic, ultrasonic, vortex, thermal flowmeters - is provided. The text includes comparative examples, placing these new types of meters in the context of more traditional ones, such as differential pressure, turbine, and positive displacement flowmeters.

This book set provides an overview of the methodologies of bio-processing, sustainable production of agri-food waste, the assessment and management of bioactive molecule production from microbial-valorization of agri-food waste, and their industrial applications. This set also provides an overview of the tools and processes that make or modify products and improve plants for specific uses, and discusses the utilization of livestock in agricultural systems by the use of microbial approach. The authors examine technical concepts and processes for the enhanced bioproduction of various bio-products for commercial interest. They also discuss the main process conditions needed to overcome the difficulties of using waste as alternative raw materials and cover the main processes for obtaining the relevant enzymes for commercial purpose. They then review the technical-economic details on the advantages and disadvantages of exploring the waste recovery chain. Fianlly, they explore the main technological advances in the recovery of residues in functional products and encompass solid research to explore the broad potential of future microbial applications. This book is intended for biotechnologists, biologists, bioengineers, biochemists, microbiologists, food technologists, enzymologists, and related researchers.

Energy and power are fundamental concepts in electromagnetism and circuit theory, as well as in optics, signal processing, power engineering, electrical machines, and power electronics. However, in crossing the disciplinary borders, we encounter understanding difficulties due to (1) the many possible mathematical representations of the same physical objects, and (2) the many possible physical interpretations of the same mathematical entities. The monograph proposes a quantum and a relativistic approach to electromagnetic power theory that is based on recent advances in physics and mathematics. The book takes a fresh look at old debates related to the significance of the Poynting theorem and the interpretation of reactive power. Reformulated in the mathematical language of geometric algebra, the new expression of electromagnetic power reflects the laws of conservation of energy-momentum in fields and circuits. The monograph offers a mathematically consistent and a physically coherent interpretation of the power concept and of the mechanism of power transmission at the subatomic (mesoscopic) level. The monograph proves (paraphrasing Heaviside) that there is no finality in the development of a vibrant discipline: power theory.

Reliability, Risk and Safety: Back to the Future covers topics on reliability, risk and safety issues, including risk and reliability analysis methods, maintenance optimization, human factors, and risk management. The application areas range from nuclear engineering, oil and gas industry, electrical and civil engineering to information technology and communication, security, transportation, health and medicine or critical infrastructures. Significant attention is paid to societal factors influencing the use of reliability and risk assessment methods, and to combinatorial analysis, which has found its way into the analysis of probabilities and risk, from which quantified risk analysis developed. Integral demonstrations of the use of risk analysis and safety assessment are provided in many practical applications concerning major technological systems and structures. Reliability, Risk and Safety: Back to the Future will be of interest to academics and engineers interested in nuclear engineering, oil and gas engineering, electrical engineering, civil engineering, information technology, communication, and infrastructure.

First published in 1986: The Purpose of this book is to provide working managers with a comprehensive introduction to practical operational aspects of hazardous waste management and with an extremely important foundation in relevant laws, rules and regulations.

Comprises four parts, the first of which provides an overview of the topics that are developed from fundamental principles to more advanced levels in the other parts. Presents in the second part an in-depth introduction to the relevant background in molecular and cellular biology and in physical chemistry, which should be particularly useful for students without a formal background in these subjects. Provides in the third part a detailed treatment of microscopy techniques and optics, again starting from basic principles. Introduces in the fourth part modern statistical approaches to the determination of parameters of interest from microscopy data, in particular data generated by single molecule microscopy experiments. Uses two topics related to protein trafficking (transferrin trafficking and FcRn-mediated antibody trafficking) throughout the text to motivate and illustrate microscopy techniques

The Big Book of Blob Feelings uses questions linked to specially selected, photocopiable pictures to help you explore feelings with those who struggle to communicate about their emotions. Tried, tested and loved internationally, this inspirational resource includes a wealth of material around: Blob Theory - the feelosophy, our open-question approach and the importance of allowing people to express their choices freely; Emotions - every day we all experience a wide range of feelings, a broad selection of which have been illustrated to kick-start discussions; Developmental issues - the objective of each of the sheets is to see people of all ages grow in their awareness of who they are, their uniqueness, and how they can develop those gifts further as they share with others. Each picture is accompanied by ideas and questions to kick-start class, group or one-to-one discussion so that everything in the book is relevant to your needs in your setting. The complete book is also included electronically on the accompanying downloadable resources so that you can print and re-use resources as often as you need to. The perfect companion to this book is The Big Book of Blob Feelings 2, which provides a huge range of new material while following the same structure and approach.

Provides better understanding of Persistent Organic Pollutants (POPs) and how they affect humans and ecosystems. Includes genesis, categories, environmental fate and behaviour, and associated hazards. Reviews analytical techniques involved in detection, human exposure and management. Discusses environmental dynamics of POPs. Focus is on the comprehensive account of PCDD/Fs, PCBs, and PAH; other organochlorine POPs such as DDT, lindane, and dieldrin.

Provides an understanding of (mostly) enzymatic reactions that are responsible for the function and maintenance of living things This innovative text for non-biochemistry majors includes introductory material at the beginning of each chapter that contextualizes chapter themes in real-life scenarios Online supporting materials with further opportunities for research and investigation Synthesis questions at the end of each chapter that encourage students to make connections between concepts and ideas, as well as develop critical-thinking skills

This book describes methods for statistical brain imaging data analysis from both the perspective of methodology and from the standpoint of application for software implementation in neuroscience research. These include those both commonly used (traditional established) and state of the art methods. The former is easier to do due to the availability of appropriate software. To understand the methods it is necessary to have some mathematical knowledge which is explained in the book with the help of figures and descriptions of the theory behind the software. In addition, the book includes numerical examples to guide readers on the working of existing popular software. The use of mathematics is reduced and simplified for non-experts using established methods, which also helps in avoiding mistakes in application and interpretation. Finally, the book enables the reader to understand and conceptualize the overall flow of brain imaging data analysis, particularly for statisticians and data-scientists unfamiliar with this area. The state of the art method described in the book has a multivariate approach developed by the authors' team. Since brain imaging data, generally, has a highly correlated and complex structure with large amounts of data, categorized into big data, the multivariate approach can be used as dimension reduction by following the application of statistical methods. The R package for most of the methods described is provided in the book. Understanding the background theory is helpful in implementing the software for original and creative applications and for an unbiased interpretation of the output. The book also explains new methods in a conceptual manner. These methodologies and packages are commonly applied in life science data analysis. Advanced methods to obtain novel insights are introduced, thereby encouraging the development of new methods and applications for research into medicine as a neuroscience.

This fascinating book gives readers an appreciation of how biomedical research should work and how the reality is all too often seriously flawed. Explaining the logical basis of the different research approaches used by biomedical research scientists and their relative merits, it will help readers to make more realistic appraisal of media reports linking aspects of lifestyle, environment or diet to health outcomes and thus judge whether such claims are a real effect worthy of consideration for behavior change or deserving of further research resources. Key features: increases awareness of research fraud and some of the characteristics of fraudulent science and scientific fraudsters shows that whilst outright fraud may be uncommon, fudging of results to help achieve statistical significance may be more prevalent incorporates real-life case studies highlighting some of the infamous cases of research fraud and major scientific mistakes and the impact that they have had provides a convenient overview of the research process in the biomedical sciences, with a focus on research strategy rather than individual methods find supplemental detail on the author's blog https://drgeoffnutrition.wordpress.com/about/ By raising awareness of the possibility that research data may have been dishonestly generated and outlining some of the signs and symptoms that might suggest data fabrication, Error and Fraud: The Dark Side of Biomedical Research will help students and researchers to identify the strengths and limitations of different research approaches and allow them to make a realistic evaluations of their own and others' research findings.

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Geotechnical Aspects of Underground Construction in Soft Ground comprises a collection of 112 papers, the Fujita Lecture, three Special Lectures and the Bright Spark Lecture presented at the Tenth International Symposium on Geotechnical Aspects of Underground Construction in Soft Ground, held in Cambridge, United Kingdom, 27-29 June 2022. This second edition includes four general reports on the symposium themes. The symposium is the latest in a series which began in New Delhi in 1994, and was followed by symposia in London (1996), Tokyo (1999), Toulouse (2002), Amsterdam (2005), Shanghai (2008), Rome (2011), Seoul (2014) and Sao Paulo (2017). This was organised by the Geotechnical Research Group at the University of Cambridge, under the auspices of the Technical Committee TC204 of the International Society for Soil Mechanics and Geotechnical Engineering (ISSMGE). Geotechnical Aspects of Underground Construction in Soft Ground includes contributions from more than 25 countries on research, design and construction of underground works in soft ground. The contributions cover: Field case studies Sensing technologies and monitoring for underground construction in soft ground Physical and numerical modelling of tunnels and deep excavations in soft ground Seismic response of underground infrastructure in soft ground Design and application of ground improvement for underground construction Ground movements, interaction with existing structures and mitigation measures The general reports give an overview of the papers submitted to the symposium, covered in four technical sessions. The proceedings include the written version of the five invited lectures covering topics ranging from developments in geotechnical aspects of underground construction, tunnelling and groundwater interaction (short and long-term effects), the influence of earth pressure balance shield tunnelling on pre-convergence and segmental liner loading (field observations, modelling and implications on design). Similar to previous editions, Geotechnical Aspects of Underground Construction in Soft Ground represents a valuable source of reference on the current practice of analysis, design, and construction of tunnels and deep excavations in soft ground. The book is particularly aimed at academics and professionals interested in geotechnical and underground engineering.

Focused on the latest mobile technologies, this book addresses specific features (such as IoT) and their adoptions that aim to enable excellence in business in Industry 4.0. Furthermore, this book explores how the adoption of these technologies is related to rising concerns about privacy and trusted communication issues that concern management and leaders of business organizations. Managing IoT and Mobile Technologies with Innovation, Trust, and Sustainable Computing not only targets IT experts and drills down on the technical issues but also provides readers from various groups with a well-linked concept about how the latest trends of mobile technologies are closely related to daily living and the workplace at managerial and even individual levels.

With a focus on practical acute pain management in adults in the hospital setting, this book provides health professionals with simple and practical information to help them manage patients with acute pain safely and effectively. * Combines evidence-based information with practical guidelines and protocols * Covers the pharmacology of opioids, local anesthetics, and nonopioid and adjuvant analgesic agents * Discusses management of acute pain in both surgical and nonsurgical acute pain settings including in patients with spinal cord or burns injuries and selected medical illnesses * Includes evidence-based information about management of acute pain in some specific patient groups , including the older patient, opioid-tolerant patients, and those with addiction disorders, pregnant or lactating patients and patients with obstructive sleep apnea or who have renal or hepatic impairment * Considers the role of acute pain management in the context of the current opioid epidemic and identifies possible strategies to minimise the risks. This resource will be helpful to a variety of professionals in assessing and managing acute pain.

With a focus on practical acute pain management in adults in the hospital setting, this book provides health professionals with simple and practical information to help them manage patients with acute pain safely and effectively. * Combines evidence-based information with practical guidelines and protocols * Covers the pharmacology of opioids, local anesthetics, and nonopioid and adjuvant analgesic agents * Discusses management of acute pain in both surgical and nonsurgical acute pain settings including in patients with spinal cord or burns injuries and selected medical illnesses * Includes evidence-based information about management of acute pain in some specific patient groups , including the older patient, opioid-tolerant patients, and those with addiction disorders, pregnant or lactating patients and patients with obstructive sleep apnea or who have renal or hepatic impairment * Considers the role of acute pain management in the context of the current opioid epidemic and identifies possible strategies to minimise the risks. This resource will be helpful to a variety of professionals in assessing and managing acute pain.

Presents an entertaining and accessible approach whilst also providing a rigorous and comprehensive presentation of the subject. Describes how to unveil the ages of stellar populations in distant galaxies that we cannot resolve into individual stars. Contains historical notes about these techniques, outstanding major problems, and a discussion on future developments in the field.

Presents an entertaining and accessible approach whilst also providing a rigorous and comprehensive presentation of the subject. Describes how to unveil the ages of stellar populations in distant galaxies that we cannot resolve into individual stars. Contains historical notes about these techniques, outstanding major problems, and a discussion on future developments in the field.