The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay and cost. Peri-operative Kidney Injury presents the epidemiology, risk factors, diagnosis, treatment and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

This practical manual presents the main drugs and protocols currently used in the psychopharmacological treatment of psychiatric disorders in cancer and palliative care settings and explores the principal issues involved in such treatment. Significant clinical challenges encountered in the psychopharmacological management of various psychiatric conditions are discussed, covering aspects such as side-effects and drug-drug interactions. Attention is also paid to the emerging theme of adjuvant use of psychotropic drugs for the treatment of symptoms or syndromes not primarily related to psychiatric disorders. In addition, practical suggestions are provided for dealing with special populations, including children and the elderly. The book is designed to be easy to read and to reference, with helpful concise tables and boxes. The authors include some of the most renowned clinicians working in the field of psycho-oncology.

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology (TM) series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls. Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside.

Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.

The advancements of medical technology, improvements in medical care, and increased patients' life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basic science research tools, such as techniques of flurometric labeling, genomic and proteomic high throughput screening, and genetically modified animals, promotes the swift acceleration of pain research to a stage allowing integrated investigations of pain processing mechanisms at the single cell and/or molecule level, and in a spatially and temporally controlled manner. Using multidisciplinary approaches, we can dissect the complicity of the sensory circuits connecting peripheral stimulation to maladaptive changes in the sensory pathways as well as pain perceptions at the central nervous system. Pain Research: Methods and Protocols, Second Edition provides advanced techniques and animal models that are critical for integrated pain research. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Pain Research: Methods and Protocols, Second Edition serves as an ideal guide to novice pain researchers who may not have extensive experiences in the field, or to experienced pain researchers who would like to expand their research in new directions and/or to new mechanisms in different models.

This volume describes the most recent medical guidelines for perioperative management in arthroplasty with the aim of facilitating excellent control of bleeding/thrombosis, pain and infection. For each area – hemostasis control, pain control and infection control – hot topics of key practical importance are discussed and contrasting perspectives are presented on controversial issues, covering the views of different practitioners and specialties. Using the information contained in this book, the practitioner will be in an excellent position to meet the principal goals of perioperative medical management. The information provided will assist in the choice of a multimodal guideline that minimizes the complication rate regarding bleeding and thromboembolism while not interfering with the patient’s recovery. Similarly, effective means of pain control and an optimized pain control protocol are discussed with a view to shortening hospital stay and achieving functional milestones that meet the patient’s expectations. Finally, host, wound and environmental factors relevant to infection and its prevention are explained, with discussion of the best means of prophylaxis, treatment and imaging. Surgeons, anesthesiologists and all medical practitioners and staff involved in the field of total hip and knee arthroplasty will find this book to be of value in their daily clinical practice. It will assist in the provision of enhanced medical management that ensures quicker recovery of the patient with fewer complications.

Geriatric Trauma and Critical Care provides a multidisciplinary overview of the assessment and management of the elderly patient presenting with surgical pathology. By utilizing current literature and evidence-based resources, the textbook elucidates the unique nature of caring for the elderly population. The structure of the volume provides the reader with an overview of the physiologic and psychological changes, as well as the impact on the healthcare system, associated with the aging process. Emphasis is placed on the impact of aging, pre-existing medical problems, effects of polypharmacy, advanced directives and end-of-life wishes on acute surgical problems, including trauma and surgical critical care. Special attention is given to the ethical implications of management of the aged. The multidisciplinary contributors provide a unique point of view not common to surgical texts. The textbook is the definitive resource for practicing surgeons, emergency medicine physicians, intensivists, anesthesiologists, hospitalists, geriatricians, as well as surgical residents, nurses and therapists, all who care for elderly patients with surgical emergencies.

This book proposes a didactic approach to the different aspects of pain in mental health. The various chapters cover the myths, neurophysiology, perception, measurement and management of pain in mental health. The most common problems, including mood disorders, schizophrenia, anxiety, somatoform disorders and pervasive developmental disorders, are covered. Each chapter addresses the problem of pain by putting an emphasis on the characteristics of different populations of patients suffering from mental illness. The book helps specialists working in different areas of mental health to appreciate the importance of pain problems in mental health and also offers avenues for the measurement and treatment of pain in these patients. Mental health and pain are complex issues. They also share certain mutually influential neurophysiological mechanisms, which makes it even more difficult to identify their specific individual characteristics. This duality between the somatic and psychic components can become a pitfall for the specialist in mental health since it can be difficult to disentangle the evolution of a painful condition from the mental illness.

David O'Flaherty describes the physiology and techniques of carbon dioxide measurement and the clinical significance of the capnogram.

This comprehensive, state of the art overview of pediatric and adult cardiac anesthesia brings together all the latest developments in this rapidly developing field. This text is intended both as a reference and for daily use by practicing and prospective anesthesiologists.

Thoroughly updated for its third edition, "Anesthesia for Cardiac Surgery" fills the gap between encyclopaedic references and brief outlines, presenting just the right amount of information to guide trainees and practitioners who care for cardiac surgical patients.

This edition features:
The introduction of Dr Zvara as co-editor
A new chapter on Special Considerations
Practical clinical information coupled with comprehensive descriptions of physiology
Key facts and tables summarized for convenient access.

This essential resource will prove invaluable for residents, fellows, and practicing anesthesiologists.

Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.

For over thirty years, the Oxford Handbook of Clinical Specialties has guided students and junior doctors through their clinical placements, renowned for providing all the information needed for both practice and revision in a deceptively small package. Now in its eleventh edition, the Handbook has been revitalized by an expanded team of specialty experts and junior doctors to guide readers through each of the specialties encountered through medical school and Foundation Programme rotations, while remaining true to the humanity and patient focus of the original edition. Updated with the latest advice and clinical guidelines, packed full of high-quality illustrations, boxes, tables, and classifications, and with a brand new chapter on how to survive your junior doctor years and beyond, this handbook is ideal for both study and use at direct point of care. Each chapter is clear and concise and filled with medical gems, with features including ribbons to mark your most-used pages and mnemonics to help you memorize and retain key facts. With reassuring and friendly advice throughout, this is the ultimate guide and revision tool for every medical student and junior doctor for each clinical specialty placement. This well-loved Handbook remains the perfect companion to the Oxford Handbook of Clinical Medicine, together encompassing the entire spectrum of clinical medicine and unmatched by any competitor in their class, helping you become the doctor you want to be.

This is the first dedicated revision aid for the Single Best Answer component of the Final FFICM, added to the written examination in July 2014. It contains 240 SBA practice questions, divided into eight papers covering the Faculty of Intensive Care Medicine curriculum. Each answer consists of a short explanation, allowing a quick review of the correct answer, and a long explanation, providing a more in-depth discussion of the question topic. All answers are also fully referenced, encouraging further reading and providing sources for more detailed study. In combination with the companion volume, Multiple True False Questions for the Final FFICM, this guide allows readers to access full written mock exams in the style and format of the official FFICM examination, and is an invaluable resource for trainees in intensive care medicine.

"This book is a 'must have' resource in every physician/clinician practice setting."--Martin Grabois, M.D., Professor of PM&R, Baylor College of Medicine, Houston,TX. Dr. Vasudevan draws upon an accumulated reservoir of clinical expertise to provide readers with an up-to-date and highly readable guide to multidisciplinary pain management. . . . If only this book was available years ago"--Francis J. Keefe, PhD. Professor of Psychology, Psychiatry and Anesthesiology, Duke University, Durham, NC. This practical volume brings multidisciplinary innovations to the treatment of chronic pain. It argues expertly for the benefits of a biopsychosocial approach over current pain treatments more suited to acute care. The author's insights into the complexity of chronic pain and critiques of common but inconsistent unimodality pain management methods underscore the need for targeted multi-disciplinary pain programs. Among a wealth of useful clinical nuggets, readers will find guidance on adding "virtual" support to a pain management team, details on ways patients can take an active role in dealing with their chronic pain, and the original concept of the "back attack." Included in the coverage: Pain theories and factors behind chronic pain-its application in treatment. Cognitive behavioral coping strategies. Treatments that have questionable or controversial evidence. Evaluation of disability in patients with chronic pain. Creating a virtual multidisciplinary team. Common pain problems: low back pain, complex regional pain syndrome, myofascial pain syndrome, fibromyalgia. Multidisciplinary Pain Management will enhance the work of diverse practitioners, including health and clinical psychologists, family and other primary care physicians, psychiatrists, occupational and physical therapists, and rehabilitation specialists.

Specialists estimate that as many as 60 million Americans suffer from chronic pain, and approximately 20 percent of the population in most developed countries reports having chronic pain. According to one study, chronic back pain alone afflicts more than four million Americans, and nearly 50 percent of these are disabled by it. Pain is the most frequent cause of disability in the United States, with as many as 50 million Americans on short- or long-term disability leave from work at any one time. As these figures suggest, chronic pain is extremely difficult to treat successfully-it is a complex and baffling phenomenon, poorly understood even in the medical centers devoted to its diagnosis and treatment. In Heal the Pain, Comfort the Spirit Dorene O'Hara, an anesthesiologist with extensive training in pain management and clinical pharmacology, explores treatment techniques developed over many years of studying, treating, and lecturing on chronic pain. She also examines the important contributions made by other clinical professionals and by practitioners of alternative medicine. Combining a general survey of the forms of pain therapy with suggestions for how patients can find the most appropriate treatment plan for themselves, Heal the Pain, Comfort the Spirit provides needed answers for pain sufferers as well as practitioners.

Part of the highly popular Practical Approach to Anesthesia series, this new edition combines the comprehensive depth of a textbook and the user-friendly features of a practical handbook. Focusing on clinical issues in pediatric anesthesia, it contains the in-depth information you need for daily practice and study, presented in a concise, bulleted format for quick reference. With its emphasis on developmental aspects of pediatric anesthesia, numerous illustrations and tables, and methodical approach to decision making, this updated reference is an invaluable resource for anyone involved with anesthesia of children.Key Features Features new chapters on vascular biology and vascular anomalies, healing and recovery in pediatric surgery, and training and education in pediatric anesthesia. All existing chapters have been fully updated to keep you up to date. Covers key issues of growth and development – anatomic, physiologic, and pharmacologic – that form the basis for a better understanding of pediatric anesthesia. Discusses the approach to the pediatric patient, clinical and operational aspects of pediatric anesthesia, anesthetic management of normalities and abnormalities of each organ system, and special situations such as fetal surgery, anesthesia outside the operating room, and trauma. Provides a clear understanding of anomalies, embryology, anatomy, and surgery so that you’re well prepared to choose the best induction, maintenance, and emergence techniques, as well as make informed monitoring and equipment decisions. Presents information in a bulleted, outline format for easy reference and review. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

Automated Drug Delivery in Anesthesia provides a full review of available tools and methods on the drug delivery of anesthesia, bridging the gap between academic development, research and clinical practice. The book takes an interdisciplinary approach, pulling information about tools developed in other disciplines such as mathematics, physics, biology and system engineering and applying them to drug delivery. The book's authors discuss the missing element of complete regulatory loop of anesthesia: the sensor and model for pain pathway assessment. This is the only book which focuses specifically on the delivery of anesthesia.

This book comprises structured questions and answers that closely simulate the structured oral examination (SOE) format of The Royal College of Anaesthetists' final FRCA examination. The style of exam questions has changed over the years and this book matches the most recent changes in this updated exam. It will consist of ten sets (chapters) of complete SOE papers. Each SOE set (chapter) includes one long case, three short cases and four different applied basic science topics (anatomy, physiology, pharmacology and clinical measurement). As this book will be presented in the format of complete examination papers, it will enable candidates to assess their knowledge and skills. It will also assist trainers in setting up mock exams. With thorough revision of this book, trainees can confidently sit their exams. The authors have been organising final FRCA viva courses for the past five years, running four exam preparation courses a year, attended by about 200 trainees each year. This book includes updated knowledge based on the syllabus and more recent questions asked in the FRCA examination. It is, therefore, essential study material for trainees and a great educational tool for trainers. This book will also help candidates all over the world to pass highly competitive postgraduate examinations in anaesthesia. It is an invaluable educational resource for all anaesthetists.

The past few decades have seen major impacts of different pandemics and mass casualty events on health resource use in terms of rising healthcare costs and increased mortality. In this context, the development of acute respiratory failure in patients requires the use of mechanical ventilation, either invasive or noninvasive. Recently, noninvasive ventilation (NIV) has proved to be a valuable strategy to reduce mortality rates in patients. This is the first book to describe the clinical indications of NIV in patients who have been hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. Compiled by internationally respected experts, it offers comprehensive coverage of all aspects of noninvasive mechanical ventilation in public health emergencies, such as equipment needs and guidelines for health organizations. Considering recent events (SARS, H1N1 influenza pandemic), the book concludes with a critical review of current studies and future prospects for the use of NIV, offering a valuable resource for all practitioners managing mass casualty incidents and disasters.

The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Key features: * Provides a clear explanation for many of the pain generators in low back pain and illuminate this perplexing and ubiquitous problem. * Addresses a gap in the existing literature, as "non-specific" or mechanical lumbosacral spine pain accounts for by far most chronic spinal pain sufferers' complaints for clinicians dealing with spinal pain syndromes like general medical practitioners, and spinal specialists in various fields such as sports medicine. * Illustrates anatomical structures that can be injured and thus become responsible for causing mechanical lumbosacral spine pain, frequently, such injuries cannot be detected on sophisticated imaging such as MRI.

Pelvic Pain Management is an evidence-based guide to understanding the basics of pain mechanisms, pharmacology, invasive and noninvasive treatment modalities, and pain management protocols related to the complex problem of pelvic pain. The book addresses all aspects of pain management essentials, new technologies and devices, chronic pain issues, opioid and non-opioid pharmacology, including newly approved drugs, and special populations including pediatrics, the elderly, and patients with co-existing disease. It provides information on performing a proper physical exam, diagnosing the origins of the pain, and developing a treatment plan with emphasis on multidisciplinary management. This is an ideal resource for physicians, trainees, and nurses looking to recognize, diagnose and manage all major issues related to pelvic pain.