Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology (TM) series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls. Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside.

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.

The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This practical manual presents the main drugs and protocols currently used in the psychopharmacological treatment of psychiatric disorders in cancer and palliative care settings and explores the principal issues involved in such treatment. Significant clinical challenges encountered in the psychopharmacological management of various psychiatric conditions are discussed, covering aspects such as side-effects and drug-drug interactions. Attention is also paid to the emerging theme of adjuvant use of psychotropic drugs for the treatment of symptoms or syndromes not primarily related to psychiatric disorders. In addition, practical suggestions are provided for dealing with special populations, including children and the elderly. The book is designed to be easy to read and to reference, with helpful concise tables and boxes. The authors include some of the most renowned clinicians working in the field of psycho-oncology.

This volume describes the most recent medical guidelines for perioperative management in arthroplasty with the aim of facilitating excellent control of bleeding/thrombosis, pain and infection. For each area – hemostasis control, pain control and infection control – hot topics of key practical importance are discussed and contrasting perspectives are presented on controversial issues, covering the views of different practitioners and specialties. Using the information contained in this book, the practitioner will be in an excellent position to meet the principal goals of perioperative medical management. The information provided will assist in the choice of a multimodal guideline that minimizes the complication rate regarding bleeding and thromboembolism while not interfering with the patient’s recovery. Similarly, effective means of pain control and an optimized pain control protocol are discussed with a view to shortening hospital stay and achieving functional milestones that meet the patient’s expectations. Finally, host, wound and environmental factors relevant to infection and its prevention are explained, with discussion of the best means of prophylaxis, treatment and imaging. Surgeons, anesthesiologists and all medical practitioners and staff involved in the field of total hip and knee arthroplasty will find this book to be of value in their daily clinical practice. It will assist in the provision of enhanced medical management that ensures quicker recovery of the patient with fewer complications.

Geriatric Trauma and Critical Care provides a multidisciplinary overview of the assessment and management of the elderly patient presenting with surgical pathology. By utilizing current literature and evidence-based resources, the textbook elucidates the unique nature of caring for the elderly population. The structure of the volume provides the reader with an overview of the physiologic and psychological changes, as well as the impact on the healthcare system, associated with the aging process. Emphasis is placed on the impact of aging, pre-existing medical problems, effects of polypharmacy, advanced directives and end-of-life wishes on acute surgical problems, including trauma and surgical critical care. Special attention is given to the ethical implications of management of the aged. The multidisciplinary contributors provide a unique point of view not common to surgical texts. The textbook is the definitive resource for practicing surgeons, emergency medicine physicians, intensivists, anesthesiologists, hospitalists, geriatricians, as well as surgical residents, nurses and therapists, all who care for elderly patients with surgical emergencies.

This book proposes a didactic approach to the different aspects of pain in mental health. The various chapters cover the myths, neurophysiology, perception, measurement and management of pain in mental health. The most common problems, including mood disorders, schizophrenia, anxiety, somatoform disorders and pervasive developmental disorders, are covered. Each chapter addresses the problem of pain by putting an emphasis on the characteristics of different populations of patients suffering from mental illness. The book helps specialists working in different areas of mental health to appreciate the importance of pain problems in mental health and also offers avenues for the measurement and treatment of pain in these patients. Mental health and pain are complex issues. They also share certain mutually influential neurophysiological mechanisms, which makes it even more difficult to identify their specific individual characteristics. This duality between the somatic and psychic components can become a pitfall for the specialist in mental health since it can be difficult to disentangle the evolution of a painful condition from the mental illness.

The past few decades have seen major impacts of different pandemics and mass casualty events on health resource use in terms of rising healthcare costs and increased mortality. In this context, the development of acute respiratory failure in patients requires the use of mechanical ventilation, either invasive or noninvasive. Recently, noninvasive ventilation (NIV) has proved to be a valuable strategy to reduce mortality rates in patients. This is the first book to describe the clinical indications of NIV in patients who have been hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. Compiled by internationally respected experts, it offers comprehensive coverage of all aspects of noninvasive mechanical ventilation in public health emergencies, such as equipment needs and guidelines for health organizations. Considering recent events (SARS, H1N1 influenza pandemic), the book concludes with a critical review of current studies and future prospects for the use of NIV, offering a valuable resource for all practitioners managing mass casualty incidents and disasters.

Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.

This in-depth text addresses how to approach and treat the chronic pain patient struggling with problematic opioid use. It discusses the approach for patients who may be at high risk of problematic use, such as those with a history of mental illness or substance use disorder. The first part covers diagnosis and treatment, focusing on common best practices that practitioners can adapt to any practice. Two of the chapters detail alternative and replacement therapies for opioid. Two more cover special issues in the treatment of women and older patients. The second part reviews the ethical, legal, regulatory, and policy issues surrounding the treatment of patients with comorbid pain and addiction. The book includes strategies for documentation that mitigate the risk of legal issues or ethical boundary crossings. The last part of the book addresses treating comorbid pain and opioid use disorder in different medical settings and the treatment of co-occurring mental illnesses and substance abuse. Treating Comorbid Opioid Use Disorder in Chronic Pain is of great value to psychiatrists, pain physicians, primary care providers, social workers, drug rehabilitation centers, and other behavioral health professionals.

A key requirement of the primary and final FRCA examinations is a sound understanding of the basic sciences behind anaesthetic practice. It is important to be able to describe these principles clearly, particularly in the viva section of the examinations. Featuring several new topics, this fully updated new edition of this best-selling book provides all the important graphs, definitions and equations which may be covered in the examinations, together with clear and concise explanations of how to present them to the examiner and why they are important. Packed full of precise, clear diagrams with well structured explanations, and with all key definitions, derivations and statistics, this is an essential study aid for all FRCA examination candidates.

David O'Flaherty describes the physiology and techniques of carbon dioxide measurement and the clinical significance of the capnogram.

Local Anaesthesia in Dentistry is a practical guide for both students and general practitioners to this essential area of clinical practice.
Highly illustrated in full colour throughout, the book provides clear and practical guidance to the administration of local anaesthesia. The book introduces the reader to the concept of nerve conduction and pain as well as providing an explanation of the anatomy of the trigeminal nerve. Further chapters cover such key areas of practice as regional anaesthesia, local anaesthesia in children, pharmacology, local and systemic complications, general practical aspects, the prevention of side effects and legal aspects.

Providing essential support to schools and universities that offer yoga therapy training programs, this comprehensive, edited textbook develops robust curricula, enabling them to prepare yoga therapists to integrate into healthcare settings safely and effectively. The book includes a large and international list of contributors from diverse lineages and backgrounds such as Matthew Taylor, Gail Parker and Steffany Moonaz, and is the first resource on yoga therapy that aligns with the educationl competencies of the International Association of Yoga Therapists (IAYT). It covers yoga foundations (philosophical background, ayurveda, tantra), biomedical and psychological foundations, yoga therapy tools and therapeutic skills, yogic and biopsychosocial-spiritual assessments, and professional practices. As the field of yoga therapy continues to root and grow, this book is essential for both new yoga therapy practitioners, and for schools developing training programs.

This comprehensive, state of the art overview of pediatric and adult cardiac anesthesia brings together all the latest developments in this rapidly developing field. This text is intended both as a reference and for daily use by practicing and prospective anesthesiologists.

Thoroughly updated for its third edition, "Anesthesia for Cardiac Surgery" fills the gap between encyclopaedic references and brief outlines, presenting just the right amount of information to guide trainees and practitioners who care for cardiac surgical patients.

This edition features:
The introduction of Dr Zvara as co-editor
A new chapter on Special Considerations
Practical clinical information coupled with comprehensive descriptions of physiology
Key facts and tables summarized for convenient access.

This essential resource will prove invaluable for residents, fellows, and practicing anesthesiologists.

Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

Travell, Simons & Simons' Trigger Point Pain Patterns Flip Charts, Second Edition includes the iconic muscles and pain point patterns illustrations that set the standard in the field from Travell, Simons, & Simons' Myofascial Pain and Dysfunction: The Trigger Point Manual, the definitive reference on myofascial pain, and is organized in six sections following the structure of the Clinical Considerations chapters in the manual. This spiral-bound book with a built-in easel for display and patient presentation allows for a quick clinical reference to include TrPs as part of the clinical examination. Each section contains Trigger Point (TrP) pain referral patterns that may cause or be associated with a clinical condition commonly seen in clinical practice.

This book describes the state of the art concerning some of the most hotly debated topics in anesthesia and intensive care and is at the same time intended to serve as a useful practical guide that will assist in improving outcomes. The topics covered are wide ranging and include, for example, use of the prone position in ARDS, the role of therapeutic hypothermia in the critically ill, the value of immunoglobulins in the treatment of severe sepsis, drug management of septic shock, new strategies for prevention of ventilator-associated pneumonia, non-invasive ventilation outside of the ICU, management of postoperative bleeding and prognostic factors in cardiac arrest. Written by recognized experts in the field, the book will offer a comprehensive and easy to understand update for specialists and students of anesthesia and intensive care.

Written by leading authorities in the field, Chest Pain with Normal Coronary Arteries comprehensively reviews the clinical presentation and the pathogenesis of the condition, as well as its management. This book provides a practical tool for the clinician and a bank of information and new ideas for research scientists and clinical researchers interested in understanding the causes and mechanisms of chest pain with normal coronary arteries. Whether the pain be of gastroenterologic, cardiac or endocrine in origin, the book focuses on effective diagnosis, treatment and management of different pathologies in patients. Chest Pain with Normal Coronary Arteries is an essential read for all clinicians involved in managing patients with chest pain, and those that should be aware of non-cardiac chest pain.

Practice Single Best Answer Questions for the Final FRCA: A Revision Guide covers the complete syllabus of this new-style exam. The book includes 10 papers, each of which consists of 30 questions on clinical anaesthesia, intensive care medicine and pain management. Each practice paper matches the style, number and level of questions that candidates will face in their FRCA exam. Written by a group of anaesthetists experienced in teaching clinical anaesthesia and preparing trainees for their exams, every question is supplemented with a thorough explanation, incorporating the latest research and guidelines, and further reading suggestions. The book also includes guidance on how to go about answering single best answer questions. Pitched at just the right level for the exam, Practice Single Best Answer Questions for the Final FRCA: A Revision Guide is an essential resource for all Final FRCA candidates.

This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.

"This brilliantly assembled expert compendium provides a much-needed guide for the practical application of anesthesiology in medical practice in the most bereft underdeveloped and violence-afflicted regions of the globe." -Seymour Topping, Professor Emeritus of International Journalism, Columbia University This is a comprehensive guide to the role of anesthesiologists in medical missions. In their capacity as perioperative physicians, anesthesiologists improve the safety and efficacy of surgical interventions for underserved patients in low- and middle-income countries around the world. Contributions from international experts in global health provide essential historical context, practical medical and surgical considerations for planning missions, and scenarios of "on the ground" implementation of care. The final section considers anesthesiology education in the context of global health. This is an encompassing and eye-opening resource for trainees and physicians considering participating in a medical mission and students and faculty of global health.

Bladder Pain Syndrome: A Guide for Clinicians provides a comprehensive update in the pathophysiology, epidemiology, terminology, evaluation and treatment of patients with pelvic pain perceived to be related to the urinary bladder. The volume covers the tremendous evolution during the last decade in our understanding of pain syndromes and their diagnosis and treatment. It is now clear that Bladder Pain Syndrome belongs to the family of pain syndromes, and therefore treatment has moved from the treatment of the bladder to the treatment of a pain syndrome with the special problems this presents when the pain syndrome involves urinary symptoms. Interstitial Cystitis was poorly defined and the interpretation and patient selection differed enormously around the world in many ways, making exchange of information unreliable and confusing. Bladder Pain Syndrome is clearly defined and the result is a much better patient selection. This volume provides state of the art background for making a correct evaluation and diagnosis of patients with pelvic pain and voiding problems resulting in a more focused treatment to the benefit of the patients. The volume also covers the close relationship between different pain syndromes including those outside the pelvis. Bladder Pain Syndrome: A Guide for Clinicians will be of great utility to urologists, gynecologists and all health professionals dealing with patients with pelvic pain.

From reviews of Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches: "Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches is a major textbook... [I]t should be a part of all departmental libraries and in the reference collection of pain fellows and pain practitioners. In fact, this text could be to pain as Miller is to general anesthesia." Journal of Neurosurgical Anesthesiology Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a soft cover version of the Medical section of the acclaimed Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches. It is intended as a primary reference for busy clinicians who seek up-to-date and authoritative information about medical approaches to treating chronic pain. Clinically focused resource on the medical management of chronic pain Leading edge topics, such as monitoring opioid use and abuse, the emerging role of cannabinoids in pain treatment, and the systems involved in nociceptive processing systems "Key Points" preview contents of each chapter

This book presents the development and experimental validation of the structural test strategy called Oscillation-Based Test - OBT in short. The results presented here assert, not only from a theoretical point of view, but also based on a wide experimental support, that OBT is an efficient defect-oriented test solution, complementing the existing functional test techniques for mixed-signal circuits.