Selected as a Doody's Core Title for 2021! Comprehensive, readable, and clinically oriented, Stoelting's Pharmacology & Physiology in Anesthetic Practice, Sixth Edition, covers all aspects of pharmacology and physiology that are relevant either directly or indirectly to the anesthetic practice-a challenging topic that is foundational to the practice of anesthesia and essential to master. This systems-based, bestselling text has been thoroughly updated by experts in the field, giving you the detailed information needed to make the most informed clinical decisions about the care of your patients. Offers trainees and practitioners authoritative content on all aspects of pharmacology and physiology that are relevant to anesthesiology. Features up-to-date coverage of new drugs, as well as new findings on the actions and interactions of established drugs. Discusses antimicrobials and chemotherapeutic drugs, as well as special populations such as the newborn, the parturient and fetus, the elderly, and the physiology and pharmacology of resuscitation. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

The complete, authoritative, and practical guide to ultrasound-guided nerve blocks - updated to reflect the most current NYSORA initiatives INCLUDES THREE ATLASES Hadzic's is the most comprehensive color guide to the procedures and equipment used in ultrasound guided nerve blocking. Color drawings and photographs are bolstered by concise, step-by-step instruction from the world-renowned St. Luke's Hospital in New York. The Third Edition has been updated to include more international contributors, and better align the book's content with the New York School of Regional Anesthesia's (NYSORA) standards of practice. Featuring sections that progress from the foundations of regional anesthesia to the clinical applications of nerve blocks, Hadzic's includes tips and insider perspective from the leadership of NYSORA and its academic affiliates. The book also includes three separate atlases, including a new atlas of musculoskeletal ultrasound, as well as surface anatomy, and ultrasound-guided anatomy. *A real-world emphasis on clinical utility serves as the underpinning of chapter content and drives the book's in-depth explanations of techniques and procedures *Outstanding organization begins with the foundations of peripheral nerve blocks (e.g., regional anesthesia, equipment, and monitoring and documentation) and then reviews clinical applications for both traditional procedures and ultrasound-guided procedures *Three atlases: musculoskeletal ultrasound, surface anatomy, ultrasound-guided anatomy

Offering highly visual, easy-to-read coverage of the full range of anesthesia equipment in use today, this authoritative reference is your go-to text for objective, informed answers to ensure optimal patient safety. Anesthesia Equipment, 3rd Edition, provides detailed information on the intricate workings of each device or workstation, keeping you fully up to date and helping you meet both equipment and patient care challenges. Remains unequalled in both depth and breadth of coverage, offering readable, concise guidance on all aspects of today's anesthesia machines and equipment. Details the latest machines, vaporizers, ventilators, breathing systems, vigilance, ergonomics, and simulation. Improves your understanding of the physical principles of equipment, the rationale for its use, delivery systems for inhalational anesthesia, systems monitoring, hazards and safety features, maintenance and quality assurance, special situations/equipment for non-routine adult anesthesia, and future directions for the field. Includes ASA Practice Parameters for care, and helps you ensure patient safety with detailed advice on risk management and medicolegal implications of equipment use. Highlights the text with hundreds of full-color line drawings and photographs, graphs, and charts. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Public health approaches to palliative care have been growing in policy importance and practice acceptance. This innovative volume explores the major concepts, practice examples, and practice guidelines for this new approach. The goal of 'comprehensive care' - seamless support for patients as they transition between home based care and inpatient services - relies on the principles of health promotion and community development both to ensure services are available and importantly appropriate for patients' needs. In developing contexts, where hospitals and hospices may be inaccessible, a public health approach provides not only continuity of care but greater access to good end of life care. This book provides both a historical and conceptual overview whilst offering practical case examples from affluent and developing contexts, in a range of clinical settings. Finally, it draws together research-based guidelines for future practice. Essential reading for public health researchers and practitioners with an interest in end of life care and global health as well as those involved in developing palliative care provision, International Perspectives on Public Health and Palliative Care is the first volume to present an overview of theory and practice in this emerging field.

This invaluable resource presents a state-of-the-art account of the psychology of pain from leading researchers. It features contributions from clinical, social, and biopsychological perspectives, the latest theories of pain, as well as basic processes and applied issues. The book opens with an introduction to the history of pain theory and the epidemiology of pain. It then explores theoretical work, including the gate control theory/neuromatrix model, as well as biopsychosocial, cognitive/behavioral, and psychodynamic perspectives. Issues, such as the link between psychophysiological processes and consciousness and the communication of pain are examined. Pain over the life span, ethno-cultural, and individual differences are the focus of the next three chapters. Pain: Psychological Perspectives addresses current clinical issues: * pain assessment and acute and chronic pain interventions; * the unavailability of psychological interventions for chronic pain in a number of settings, the use of self-report, and issues related to the implementation of certain biomedical interventions; and * the latest ethical standards and the theories. Intended for practitioners, researchers, and students involved with the study of pain in fields such as clinical and health psychology, this book will also appeal to physicians, nurses, and physiotherapists. Pain is ideal for advanced courses on the psychology of pain, pain management, and related courses that address this topic.

A thoroughly revised third edition of the acclaimed textbook for caregivers involved in the management of pregnant women with uncommon diseases or an unusual or rare condition. The book offers valuable case reports and experience collated by an international team of editors and contributors who are leading experts in the field. This edition contains five additional chapters covering topics like cardiac and neuraxial point of care ultrasound, substance abuse, rare inherited conditions, and anesthesia for rare fetal and placental conditions. Clear, concise management guidelines and algorithms are provided, and each chapter is written from the viewpoint of the obstetric anesthesiologist. Numerous tables, figures and photographs provide visual aids and each chapter contains valuable clinical insights highlighting the essential facts. Featuring updated figures and references, links to useful websites for further reading and a list of commonly used abbreviations. A valuable resource for obstetric anesthetists, perinatologists and other obstetric care providers.

Named a 2013 Doody's Core Title 2012 Third Place AJN Book of the Year Award Winner in Psychiatric-Mental Health Nursing

"This is a great resource for any nurse working with women."--Score: 94, 4 Stars. Doody's Medical Reviews

This is a quick-access clinical guide to the range of mental health issues and diagnoses that commonly affect women across the life span. It focuses on the unique biopsychosocial factors that make women especially vulnerable to psychological disorders and emphasizes key stressors specific to women that are precursors to mental illness. Frequent headings and bulleted, concise presentation of information facilitates reading.

In addition to discussing mental health issues specific to women, the guide covers unique populations such as disabled women, lesbian and transgendered women, female veterans, women with forensic health concerns, and women who have been the object of violence. Chapters also address childbearing issues, including menstruation-related problems, infertility and its psychological implications, and antepartum, intrapartum, and postpartum psychological disorders. Developmental milestones, the impact of culture on mental illness, and global health issues are covered as well. Tables and charts present key facts in an easy-to-read format. Key Features:

Provides a concise, easy-to-use guide to women's mental health issues across the life span for new and seasoned nurse practitioners Focuses on stressors unique to women as precursors of mental illness Delivers commonly occurring DSM-IV disorders in women, using a consistent format that includes etiology, assessment, and drug and behavioral therapeutic approaches Discusses preconception and childbearing issues, the impact of violence, female veterans, disabled women, lesbian women, and transgendered women

The concept of integrating pain management into the surgical process as a single entity is new and exciting. The use of local anaesthetic to block post-operative pain at the site of its generation is here refined into a management program allowing early mobilisation and dramatic pain control in the early post-operative period. This multimodal technique is demonstrated here with application to lower limb arthroplasty and spinal surgery. This is not only a detailed explanation and instruction in the technique and concept, but a historical perspective on its development, and will be of great interest to all orthopaedic surgeons as well as anaesthetists.

Using easy-to-understand terminology, this text covers:

• LIA methods
• Pre- and postoperative management
• How to select a needle injection location
• The benefits of combining the LIA technique with the drugs Naropin, Marcain, and Xylocaine

Color images throughout the text highlight the advantages of LIA, including:

• avoidance of sedation
• simple execution for physicians
• reduced risk of infection and blood clots
• little physiological disturbance
• earlier patient discharge and return to the workforce
• improved patient performance, outlook, and mobility
• fewer medical expenses

Advances over the past two decades have enabled physicians to revolutionize the manner in which they can assess and manage children's pain. Thirty years ago it was thought that young children did not experience pain and therefore it was not necessary to treat it. Today professionals from a variety of disciplines have contributed data that have revolutionized medical perspectives. Technological advances now enable doctors to treat acute pain in fetuses, premature neonates, infants, toddlers, children, and adolescents with increasing precision and efficacy. Research highlighting the context of chronic pain has moved them away from a mind-body dichotomy and toward an integrated, holistic perspective that leads to substantial improvement in children's adaptive functioning as well as subjective discomfort. This book covers these topics and is intended for anyone who provides medical care to children. Each chapter provides an overview of the problem, followed by a "hands on" description of relevant assessment and intervention strategies. The role of the primary care practitioner is highlighted, both as a front-line resource as well as a consumer of specialized pediatric pain treatment services. Each chapter ends with a summary and specific bullet points highlighting the most central elements, making for quick and easy reference.

Won First Prize at 2012 BMA awards in Anaesthesia Category. Lavishly illustrated by clear line diagrams and photographs, Ward's Anaesthetic Equipment is a highly accessible single source to aid understanding of the key principles behind equipment function and design. This sixth edition of the classic reference text on anaesthetic equipment is again extensively revised to reflect the very latest advances. Ward's is an invaluable resource for qualified anaesthetists, as well as essential reading for those in training or approaching examinations such as those of the Primary and Final Fellowship in the UK and Ireland. Trainees in Intensive Care Medicine, anaesthetic assistants, operating department practitioners, electronic and biomedical engineers in hospitals and manufacturers' representatives will also benefit from this most trusted guide. Provides a simple and comprehensive explanation of the function of anaesthetic equipment, ensuring its safe use in clinical practice Covers the relevant syllabus required by the FRCA and similar exams taken by trainee anaesthetists Clear line diagrams explain the working principles of each piece of equipment The physics and technology of ultrasound gains a devoted chapter, as does patient warming. There are enhancements on depth of anaesthesia monitoring, error management and ultrasound imaging in regional anaesthesia. Particular coverage of supraglottic airway devices substantially augments an extended chapter on airway equipment. Updates throughout, including on the anaesthetic workstation, infusion devices and equipment for anaesthesia in difficult locations, ensure Ward's remains the most comprehensive and current text on anaesthetic equipment.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

As recently detailed in an Institute of Medicine Report, pain represents one of the most costly and prevalent public health conditions in the United States, and the burden of pain is substantially greater for women than men. Women make up half of the world's population. Yet, the overall treatment of pain in women remains challenging to this day. The differences between men and women are anatomical, physiological and psychosocial in nature. Consequently, several unique features come to mind when discussing pain as experienced by women, such as pain related to pregnancy, pain related specifically to female organs, and chronic painful conditions which have a higher prevalence in the female population. The purpose of this book is to address the current understanding of mechanisms related to sex differences, and the clinical management of common acute and chronic painful conditions in women, using up-to-date evidence-based information. The painful conditions discussed include those that are specific to female anatomy and physiology and conditions that have a higher female prevalence. The book is divided into three sections. The first section covers basic science topics related to sex differences in pain. The epidemiology of painful conditions with female prevalence; sex differences in response to pain, and to analgesics; the role of sex hormones and genotype in pain perception and analgesia; sex differences in cerebral responses to pain revealed by brain imaging ; and the role of psychosocial factors, including psychological interventions will be discussed in this section. The second and third sections are clinically directed. The second section focuses on pain specific to female patients. Topics include the management of labor pain; the management of painful conditions during pregnancy; and the management of pain in the opioid tolerant pregnant patient. The latter includes discussion on the impact of pain management on the fetus in utero, and on the newborn who is breastfed. Chronic pain specific to females, including dysmenorrhea, chronic pelvic pain and vulvodynia will be discussed in this section. Cancer-related pain issues in women will be addressed in the chapter on persistent pain after breast cancer treatment and the chapter on interventional management of pelvic cancer pain. The third section covers painful conditions with high female prevalence. These include fibromyalgia, chronic fatigue syndrome and neuropathic pain in complex regional pain syndrome. Visceral pain with female prevalence such as irritable bowel syndrome, chronic pelvic pain of undetermined etiology will also be addressed in this section. This section also includes chapters on the presentation of cardiac pain in women; headaches including migraine; and temporomandibular joint disorders and orofacial pain. The book is intended for a wide readership, including physicians and allied healthcare professionals who encounter female patients with acute or chronic painful conditions. In addition, residents and medical students in training as well as graduate students in health sciences will benefit greatly from this book as they continue to learn about and manage difficult and complex issues related to pain in female patients.

Public health approaches to palliative care have been growing in policy importance and practice acceptance. This innovative volume explores the major concepts, practice examples, and practice guidelines for this new approach. The goal of continuity of care' - seamless support for patients in their experiences and transitions from community to primary health services to inpatient services - means that health promotion and community development become important ways to achieve a holistic health approach to end of life care. In developing contexts, where hospitals and hospices may be inaccessible, a public health approach provides not only continuity of care but greater access to good end of life care. This book provides both a historical and conceptual overview whilst offering practical case examples from affluent and developing contexts, in a range of clinical settings. Finally, it draws together research-based guidelines for future practice. Essential reading for public health researchers and practitioners with an interest in end of life care and global health as well as those involved in developing palliative care provision, International Perspectives on Public Health and Palliative Care is the first volume to present an overview of theory and practice in this emerging field.

More than 80% of patients with cancer will need the services of anesthesiology and perioperative medicine, intensive care medicine, and pain management specialists during their cancer journey for diagnostic, therapeutic, and symptom management needs, as well as for the management of recurrent disease, secondary cancers, and ongoing non-oncologic surgical needs during survivorship. Perioperative Care of the Cancer Patient is today's most up-to-date, authoritative, comprehensive reference on the acute care of surgical patients with cancer, from a team of international experts in this emerging and dynamic specialty. Covers current clinical practice and perioperative care guidelines during the entire cancer journey for both adult and pediatric patients. Includes a diverse array of topics on cancer care, such as cancer epidemiology, cancer biology, ethics in cancer care delivery, value proposition in cancer care, opportunities and challenges with research programs in perioperative cancer care, application of big data and computational sciences in cancer medicine and care delivery, and the MD Anderson Cancer Center Moon Shots Program (R). Discusses newer cancer therapies and their perioperative implications, functional assessment and prehabilitation, enhanced recovery programs in cancer care, challenges with novel cancer therapies in the care of the critically ill cancer patient, chronic and interventional pain management in patients with cancer, and more. An educational resource and clinical reference for surgeons, anesthesia practitioners, hospitalists, internists, pain physicians, intensivists, basic science researchers, and all clinicians involved in the acute care of surgical patients with cancer. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Named a 2013 Doody's Core Title "I would recommend this great little book for nurses who wish to carry a book with them in their clinical practice. It's a great addition to the growing list of books addressing pain in pediatrics."--Pediatric Pain Letter

" This book] is a practical guide to pediatric pain assessment and management for the advanced practice nurse and primary caregivers who are interested in caring for patients with pain, but whose care specialty is not pain management. For the nurses whose specialty is pain management, this text provides a quick pediatric reference of our knowledge and tools of our trade. Even though it is a 'compact guide, ' this text is well referenced with current key position statements, clinical practice guidelines, and primary references of the latest pediatric pain management research."--Pain Management Nursing

Presented in a concise, systematic format, this clinically oriented book provides nurses and physicians quick access to up-to-date information on how to assess and manage pain in infants and children, including adolescents who suffer from acute and chronic pain conditions. This book provides a comprehensive review of medications for infants and children as well as nonpharmacological interventions to achieve optimal pain management for young patients undergoing needle-related procedures as well as painful conditions related to surgery, trauma, cancer, sickle cell disease, and chronic pain. Key Features:

Describes the consequences of untreated pain on development of children Summarizes pain assessment tools recommended for verbal and preverbal patients as well as those who are critically or terminally ill Provides general principles and specific dosing recommendations for non-opioids, opioids, and coanalgesics for optimal safety and effective reduction in pain Describes the indications, medications, and ongoing care and monitoring related to the increasing use of epidural and continuous peripheral nerve block infusions for pediatric patients Provides information on how to use age-appropriate strategies for cognitive, cognitive-behavioral, and physical approaches to reduce pain Includes useful resources, such as websites, and other tools, such as pain diaries and patient education information, to support multidisciplinary teams and parents who care for children with acute and chronic pain

Designated a Doody's Core Title

"This is an excellent resource that is essential for all primary care providers." Score: 100, 5 Stars.--Doody's Medical Reviews

" P]ractitioners who oversee the treatment of chronic pain in the adult population will likely find this new reference an invaluable addition to their bookshelf."--Dimensions of Critical Care Nursing

""This book is highly recommended; it will be an indispensable addition to the professional library of every nurse practitioner who manages patients with chronic, persistent pain." "

Margaret H. Granitto, RN, MSN, CRNP Georgetown University
School of Nursing and Health Studies

Presented in a clear, systematic format, this clinically oriented book provides nurses and physicians with quick access to much-needed pain management guidelines. With a unique focus on treatment options for patients with chronic persistent pain, this guide provides critical guidance on managing difficult conditions such as fibromyalgia and neuropathic pain.

The text expertly assists practitioners in assessing pain in a variety of patient populations and provides professional insight on selecting patient-appropriate medications and interventions to achieve optimal pain management for adult patients. Key Features:

Contains the newest guidelines on how to use a combination of pain screening tools to accurately assess the nature, intensity, and occurrence of patient pain Provides information on new medications and combinations of medications to use for chronic pain Presents essential information on safe prescribing and screening tools such as the Opioid Risk Tool (ORT) and screening tools for aberrant behaviors Provides strategies for utilizing nontraditional treatment options such as acupuncture, energy therapies, and psychological and coping strategies

In this issue of the Anesthesiology Clinics, there are many exciting pharmacology reviews giving us a glimpse into future practice. It begins with a definitive review by Drs. Pamela Palmer and Ronald Miller on current and developing methods of patient-controlled analgesia. There are five focused reviews on drugs designed and utilized in pain management and drug addiction: buprenorphine, acetaminophen, an oral sufentanil preparation, and tapentadol. These reviews are timely because so many new drugs have come to market to modulate and to better target pain and inflammation. Likewise, there has been an explosion in use of a number of anticoagulants that modulate the coagulation cascade. Two reviews provide a clear understanding of how many of these newer agents work, discussion of the new recombinant activated factor VII (Novo7?), and guidelines for these drugs in clinical anesthesia and pain practice. Evolving understanding and clinical use of dexmetomidine, in the OR, ICU, and peripheral sites has reshaped the practice of sedation for a large population of patients. These topics describe highly clinically relevant perioperative agents. There are also reviews on pharmacological options in the management of patients with hypertension, cardiac disease, and new cardiac anesthesia agents in the OR and ICU. There is a special review on the role of statins in cardiac anesthesia, a very exciting and evolving topic. Also reviewed is levosimendan, a calcium sensitizer utilized for acutely decompensated congestive heart failure and shown to reduce cardiac troponin release after cardiac surgery. Lastly, the future of induction and inhalation agents and structure-based modifications are examined.

"This book is a comprehensive, very specific, clinical guide for health care providers..."--Dimensions of Critical Care Nursing

"This well-written and well-organized book is a much needed 'middle ground' resource between oversimplified introductions to pain management and a thick textbook."--Clinical Nurse Specialist

"The "Compact Clinical Guide to Acute Pain Management" provides an excellent overview of the process of pain management for adult patients in any setting."--Critical Care Nurse

This book provides much-needed guidelines that are presented in an easy-to-use, systematic format for quick access to core concepts on acute pain management. It is designed to help busy practitioners accurately assess pain in a variety of patient populations, and select patient-appropriate medications and interventions to achieve optimal pain management for adult patients.

Intended for use in primary care, internal medicine, and acute- and long-term care settings, this book covers the topics of acute pain assessment, both pharmacologic and nonpharmacologic treatment options, current information from national guidelines, along with regional anesthesia techniques, patient-controlled analgesia, and epidural pain management. Key Features:

Offers important new perspective on combination use of pain scales to accurately predict individual pain management needs for more customized and effective management Delivers information on how to treat acute pain in hospitalized patients who also suffer from chronic pain and substance abuse Offers new information on opioid polymorphisms and their surprising effect on pain medication effectiveness Includes a special chapter on managing pain in difficult-to-treat patient populations

This is an essential reference for primary care providers in clinics, hospitals, specialty care, and critical care to assess pain in general populations and provide tips for performing pain assessment on patients with acute pain.

Pain is a pervasive symptom present in multiple areas of medicine. It is imperative that physicians not only evaluate and diagnose the source of pain, but that they also recognize how to manage the actual pain symptoms with effective treatment. Handbook of Acute Pain Management is an essential reference for professionals to enhance their knowledge of pain therapies. Covering both pharmacologic and non-pharmacologic approaches to treatment, this text provides updates on the most recent developments in the management of pain. This includes information on potential drug-drug and drug-disease interactions, patient controlled analgesia devices, and the emergence of continuous catheter techniques. The text also addresses pain management issues in special populations such as pediatric, opioid tolerant, and elderly patients.

Addressing both routine and complex situations with practical decision-making tools, Evidence-Based Practice of Anesthesiology, 4th Edition, helps anesthesiologists make sound decisions in everyday practice. World-renowned authority, Dr. Lee A. Fleisher, takes an evidence-based approach to a variety of high-impact topics related to effective perioperative patient management: preoperative assessment; monitoring and administration of anesthesia during surgery; postoperative intensive care management; and postoperative pain management. The 4th Edition has been updated from cover to cover, helping you make informed clinical decisions based on reliable, up-to-date guidance in every aspect of patient care. Explores important issues in perioperative management, discussing the available options, examining the relevant research, and presenting practical recommendations. Features concise, to-the-point chapters with numerous quick-reference tables for fast and effective decision making. Includes decision trees throughout to provide visual guidance and a logical flow of key decision points. Contains nine new chapters on how to identify patients at risk for postoperative neurocognitive disorder; the best strategy for perioperative ACE and ARB agents; emergency laparotomy; optimal postoperative analgesia and the opiate naive patient; the best method for perioperative handoffs; myocardial injury after non-cardiac surgery (MINS); and more. Helps you master the current best practices you need to know for successful day-to-day practice and oral board review. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Whether initiated by injury or disease, induced and sustained by changes in the nervous system, or manifested by society and culture, chronic pain can change one's first-person experience of the body and the world, and ultimately impacts cognitions, emotions, and behavior. Many fine medical books address the causes and management of chronic intractable pain, but rarely do they focus on the ways that such pain creates illness and is experienced and expressed by persons in pain. Maldynia: Multidisciplinary Perspectives on the Illness of Chronic Pain is about chronic pain that has progressed to a multidimensional illness state in and of itself. Although often dismissed as such, this pain is not imaginary, but rather represents an interaction of neurobiological processes, emotional and behavioral responses, and socio-cultural effects and reactions that become enduring elements in the life and world of the pain patient, and often remain enigmatic for those who provide care. Taking a comprehensive approach that covers science, humanities, and culture, this volume emphasizes the need for researchers, clinicians, and caregivers to regard the ways in which chronic intractable pain becomes illness and affects a patient's biological, social, and psychological states, as well as his or her sense of self. Edited by neuroscientist and neuroethicist James Giordano, this book contains 17 insightful chapters representing medicine, neuroscience, psychology, philosophy, ethics, history, art, and the ministry, this volume: * Provides an overview of the history of pain and its treatment since Hippocrates * Addresses the neurobiology and experience of chronic pain * Discusses possible relationships of chronic pain to spirituality * Details the role and value of narrative and expression, as well as technology in assessing maldynic pain * Posits the basis for an ethic of pain care * Explores the problematic nature and implications of pediatric maldynia * E

Guest Editor Dane Nichols, MD, has assembled a panel of experts focusing on Hemodynamic Support in Septic Shock. Topics include: Oxygen Delivery and Consumption: A Macro-Circulatory Perspective; Mean Arterial Pressure: Therapeutic Goals and Pharmacologic Support, Mechanisms; Detection and Potential Management of Microcirculatory Disturbances; Detection of Hypoxia at the Cellular Level; Type A & B Lactic Acidosis: Recognition, Kinetics, and Associated Prognosis; Venous blood gases: What Can They Tell Us About the State of the Circulation; Noninvasive Assessment of Cardiac Preload and Performance through CO2 Rebreathing/ETCO2 Monitoring.

Pain Medicine Board Review is a comprehensive guide for preparing for the American Board of Medical Specialties (ABMS) certification or recertification in Pain Medicine, and for residents preparing for in-training examinations in Pain Medicine. The text is organized into 28 chapters covering topics such as Anatomy, Physiology of Pain, Pharmacology, Diagnosis of Pain, and various pain syndromes. Each section includes questions, answers, and detailed explanations with highlighted key points, and concise further reading lists. Questions follow the ABMS style, and the explications of answers carefully address all points in the ABMS content outline for Pain Medicine. A section on imaging includes high quality magnetic resonance images, ultrasound images, fluoroscopic images and other images that will enable the examination candidate to answer questions that determine knowledge of pathological states as compared to normal and complications of treatments.

Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.

In this issue, Guest Editors Pratik Panharipande and Wesley Ely look at modern Sedation techniques in the critically ill. Topics include: "Pharmacology of commonly used sedatives and analgesics in the ICU," "Pharmacology of newer agents for sedation and analgesia in the critically ill," "Current sedation practices: lessons learned from recent international surveys," "Sedation and Immunomodulation," "Sedation and sleep disturbances in the ICU," and more!