The 2022 edition of Rules and Guidance for Pharmaceutical Manufacturers and Distributors, known as 'The Orange Guide', is the essential reference for all manufacturers and distributors of medicines in the UK.It provides you with a single authoritative source of European and UK guidance, information and UK legislation relating to the manufacture and distribution of human medicines, active substances, and brokering medicines.The new 11th edition has been updated to incorporate changes made after the UK's exit from the European Union on the 31st January 2020

The Economics of Biotechnology is a highly accessible book dealing with some of the most crucial issues to arise in this area. Special attention is paid to consumer, ethical and environmental concerns as well as questions relating to trade policy, intellectual property, who will receive the benefits, international development and the role of international institutions such as the WTO. The authors examine concerns arising from the application of biotechnology in the agri-food industrial complex, and many of the issues discussed also have implications for the medical and pharmaceutical aspects of biotechnology. Fundamental questions regarding the application of standard economic analysis to biotechnology are resolved using traditional neo-classical analyses as well as less mainstream methods. Through exploring a number of approaches, original and unexpected conclusions are reached. This coherent and relevant treatment of the myriad facets of biotechnology will be welcomed by academics, scholars, and economists with a specific interest in international economics or technology, international policymakers, and economic commentators.

Biotechnology and Competitive Advantage investigates the development of biotechnology in Europe and the United States. It examines why Europe has fallen behind in applying biotechnology, when its scientific capabilities are largely comparable to those in the US. In addition it sheds new light on the wider context of the theory of growth of new technologies. This innovative book brings together a wide range of material concerning socio-economic aspects of the development of biotechnology in Europe and the US. Issues discussed include: * European policy for biotechnology, in individual countries and at the European Union level * risk regulation and the ways in which industry, regulators and non-government organizations manage risk regulation and the perception of risk * the formation and roles of biotechnology firms in Europe and the US and their relative capabilities * gene therapy development in Europe and the US * the impact on Europe of overseas biotechnology research by European multinationals. This book argues in favour of developing an integrated research and development system which will strengthen the research and development capabilities of all the actors involved. This book will be of great interest to science policymakers; businesses and academics studying the development of biotechnology and students of economics and business studies throughout Europe and the US.

The 2022 edition of the Rules and Guidance for Pharmaceutical Distributors, the 'Green Guide', is the essential reference for all distributors, brokers of human medicines, importers and distributors of active substances in the UK.It provides you with the single authoritative source of European good distribution practices and UK guidance, information and UK legislation on these activities.The new 5th edition has been updated to incorporate changes made after the UK's exit from the European Union on the 31st January 2020.It also incorporates new guidance on pharmacovigilance for wholesalers, the naming of sites on a licence, self-inspection, and the responsible person for import.It brings together EU guidance on good distribution practice and the MHRA's expectations for compliance. There is also a new flowchart for the registration of handling active substances

This groundbreaking book is the first comparative analysis of the relative strengths of global bioregions. Growth Cultures investigates the rapidly growing phenomena of biotechnology and sets this study within a knowledge economy context. Philip Cooke proposes a new knowledge-focused theoretical framework, 'the New Global Bioeconomy', against which to test empirical characteristics of biotechnology. In this timely volume, Cooke unifies concepts from the sociology of science, economic sociology and evolutionary economic geography to focus on the problems and prospects for policy agencies worldwide trying to build 'biotechnology clusters'. He develops a superior policy approach of thinking in terms of platforms that integrate proximities and pipelines, which will be of significant interest for the scientific and technological communities as well as economic development policy communities. Growth Cultures will make fascinating reading for students, policy makers and researchers across management and business studies, innovation and knowledge studies, sociology, science and technology policy, applied economics, development studies and regional science.

First published in 1985, this book is about Imperial Chemical Industriesa (TM) response to the changing social, political, business and economic environment over the past twenty years. Using personal interviews and archival material, Andrew Pettigrew examines the evolution of business strategy, organisation structure and culture, technology and union-management relations within this corporate giant over an extended period of time. It is a compelling account, told from the inside, by one of the worlda (TM)s leading management and organisation theorists. The Awakening Giant has made a major practical and theoretical contribution to the study of corporate strategy, organisational analysis and change, and business history. Anyone with an interest in managing change in a large corporation will find this reissue rewarding reading.

Until now, information regarding chemical spill clean-up was available only through manufacturer's literature from an individual firm, or scattered in the traditional textbooks on remediation engineering and hazardous waste management. Survey of Chemical Spill Countermeasures provides a one-stop source of information on how to clean up spill sites in safe, acceptable ways. Because of the ever-growing need to maintain constant vigilance over hazardous chemicals and potential leaks and spills, this reference will become an important source for the practicing environmental engineer and field technician.
Survey of Chemical Spill Countermeasures provides operators with useful information on how to clean up sites, including controlling leakage, containment of spills on land and water, and ways to safely transfer and store the contaminants. Additionally, the book includes up-to-date information on containment and treatment technologies, from dredging and vacuuming, to solid and vapor treatment systems.

Presenting extensive, recent advances in the field of hydrocracking-including new catalytic materials, reaction mechanisms and pathways, as well as new hydrocracking processes and applications-this unified reference covers in detail both catalysts and processes. Analyzing every important area related to the subject, Hydrocracking Science and Technology describes the petroleum refining process and the history of hydrocracking catalyst composition, preparation, and manufacturing methods deactivation and reactivation the correlation between catalyst composition and performance catalyst characterization and reclamation techniques reaction mechanisms and much more

* Focus on seven critical, fast-paced industries where innovation capability is essential * Written by two prominent thought leaders with 50 years of combined experience working with hundreds of companies across industries * Provides templates to immediately put the book's frameworks in place to develop an organization's innovation plan

ERIN BROCKOVICH meets SILENT SPRING in this astounding true story of a lawyer who spent two decades building a case against one of the world's largest chemical companies, uncovering a shocking history of environmental pollution and heartless cover-up. The story that inspired the motion picture from Participant Media/Focus Features, starring Mark Ruffalo, Anne Hathaway, Bill Pullman and Tim Robbins, directed by Todd Haynes. In 1998, Robert Bilott was a 33-year-old Cincinnati lawyer on the verge of making partner when his career and life took an unforeseen turn. He was taken by surprise when he received a call from a man named Earl Tennant, a farmer from West Virginia with a slight connection to Robert's family. Earl was convinced the creek on his property, where his cattle grazed, was being poisoned by run-off from a neighbouring factory landfill. His cattle were dying in hideous ways, and he hadn't even been able to get a water sample tested by local agencies, politicians or vets. As soon as they heard the name DuPont - the area's largest employer - he felt they were reluctant to investigate further. Once Robert saw the thick, foamy water that bubbled into the creek, the gruesome effects it seemed to have on livestock, and the disturbing frequency of cancer and lung problems in the surrounding area, he was persuaded to fight against the type of corporation his firm routinely represented. With all the cards stacked against him, Rob happened upon a stray reference in a random memo to a chemical called PFOA - a substance he'd never heard of that is used in the manufacture of Teflon. From that one reference, he ultimately gained access to 110,000 pages of DuPont documents, some of them fifty years old, that reveal decades of medical studies proving the harmful - more often than not fatal - effects of PFOA in animals and humans. And yet PFOA sludge had still been dumped into rivers and landfill, endangering many lives. The case of one farmer soon spawns a class-action suit and the shocking realisation that virtually every person on the planet has been exposed to PFOA and carries the chemical in his or her blood. This is the unforgettable story of the lawyer who worked tirelessly for twenty years to get justice for all those who had suffered because of this chemical.

* Focus on seven critical, fast-paced industries where innovation capability is essential * Written by two prominent thought leaders with 50 years of combined experience working with hundreds of companies across industries * Provides templates to immediately put the book's frameworks in place to develop an organization's innovation plan

First published in 1985, this book is about Imperial Chemical Industries' response to the changing social, political, business and economic environment over the past twenty years. Using personal interviews and archival material, Andrew Pettigrew examines the evolution of business strategy, organisation structure and culture, technology and union-management relations within this corporate giant over an extended period of time. It is a compelling account, told from the inside, by one of the world's leading management and organisation theorists. The Awakening Giant has made a major practical and theoretical contribution to the study of corporate strategy, organisational analysis and change, and business history. Anyone with an interest in managing change in a large corporation will find this reissue rewarding reading.

The biotechnology industry is an extremely important sector in the developed world's economies. This book, with contributions from an international array of experts, explains why biotechnology companies in different countries concentrate in a small number of locations and what accounts for the success some of these companies then go on to have.
This interesting book covers such themes as:
* the role of small firms in US biotechnology clusters
* geographic clustering in the UK
* case studies involving the sectors in a cross-section of European companies
With such international contributions, this book will be of interest to students and academics involved in Industrial Organization, Innovation Studies and Business Organization. Not only that, professionals with an interest in international business will also find this to be a very useful read.

As chemical companies strive to be more competitive in the world economy, it is essential that their employees, including sales and marketing personnel, as well as administrative support groups understand the basic concepts of the science upon which the industry is based. The authors, who have over 100 years of combined experience in the chemical industry, developed this easy-to-read book to provide a fundamental understanding of the chemical industry for non-chemists and those poised to enter the chemical profession.

Designed specifically for self-study, Chemistry and the Chemical Industry: A Practical Guide for Non-Chemists reviews the important aspects of industrial chemistry in a way that can be easily understood even if you have not taken any formal chemistry courses. The authors provide a clear, concise presentation of the foremost issues behind the chemical discipline along with key definitions and concepts so you can readily obtain an appreciation of the nature of the industry and its contribution to society. Even though you are not at the lab bench, you can still understand, recognize, and partake in discussions about the work being done at your company. Compiled in a straightforward and accessible manner, this book is unique in that it bridges the gap between nonscientific employees and the scientific world in which they operate.

The first chapter begins with a description of the chemical industry. It defines the most common terms used in chemistry, drawing on nonscientific analogies whenever possible. In the following chapters, the authors review the concepts and terminology of organic and inorganic chemistry, polymer chemistry, high volume chemicals, and environmental concerns about chemical production with each subject presented as a graphic representation accompanied by a description. Finally, there is a short compilation of general information sources for further study. Chemistry and the Chemical Industry: A Practical Guide for Non-Chemists will allow you to communicate effectively within your organization and become more familiar with this vital industry.

Emphasizes the importance of choosing the correct project and defining This newly revised and expanded reference/text describes the economics and organization of project development, from overall venture managem ent to plant start-up, and considers offshore endeavors, risk analysis, and environmental permits and regulations. Projecting costs using t he chemical engineering plant index, Planning, Estimating, and Control of Chemical Construction Projects, Second Edition supplies a rational method for easy cost projection and is a superb reference for cost, p roject, chemical, civil, plant, mechanical, and industrial engineers; and project, construction, and business managers; and an excellent tex t for upper-level undergraduate and graduate students in these discipl ines.

Reflecting the R&D efforts in the field that have resulted in a plethora of novel applications over the past decade, this handbook gives a comprehensive overview of the tangible benefits of nanotechnology in catalysis. By bridging fundamental research and industrial development, it provides a unique perspective on this scientifically and economically important field. While the first three parts are devoted to preparation and characterization of nanocatalysts, the final three provide in-depth insights into their applications in the fine chemicals industry, the energy industry, and for environmental protection, with expert authors reporting on real-life applications that are on the brink of commercialization. Timely reading for catalytic chemists, materials scientists, chemists in industry, and process engineers.

Contents:
Part 1: myths about technology; pressure vessels must be fitted with relief valves (or bursting discs); if a vessel is exposed to fire, it should be emptied as quickly as possible; accidents are due to human failing, so we should eliminate the human element when we can; if a flammable material has a high flashpoint, it is safe and will not explode; blast walls provide the ultimate protection against explosions; we can remove hazards; the public believe we are making the world a better place; fire is worse than smoke; accidents are due to a coincidence of unlikely events; computers introduce new problems; the most valuable writings on safety are codes and standards. Part 2: myths about management; engineers should respond to market needs; many questions can be answered by substituting numbers in well-established equations; policies lead to action; treating employees, customers and suppliers well is good business in the long run; stress is a major cause of ill-health today. Part 3: myths about toxicology and the environment; we should look for the effects of substances that have not yet been studied; the causes of cancer are environmental; scientists should be held responsible for the results of their actions; we should recycle whenever possible; entropy is increasing all the time; myths in other walks of life; afterthoughts.

The Muspratt family form a fascinating dynasty in the history of British commerce and manufacturing. Associated principally with the development of the chemical industry in Liverpool - James Muspratt (1793-1884) was the first person to make alkali on a large scale using the Leblanc Process - the three generations of the family also contributed to wider Victorian and Edwardian culture through their interests in politics, education (founding the Liverpool College of Chemistry in 1848), art, literature and theatre. This is the first study to present the history of the Muspratts as a family group and to consider the entrepreneurial spirit they brought to chemical manufacture in Britain and to their many other ventures.

Democratizing Technology provides a much-needed fresh perspective on the regulation of chemicals, and an important contribution to green thinking about technology.Caroline Lucas, Green Party MEP. This book is an excellent critique of the current risk-based approach to technology. By exploring the philosophical underpinnings and the practical applications of current policy on science and technology, Chapman exposes the serious flaws in allowing economic considerations to dominate the agenda in this area. Her proposals for reform are expertly constructed and deserve urgent and serious consideration by policy-makers.Dr Stuart Parkinson, Executive Director, Scientists for Global Responsibility. In this important book Anne Chapman argues that decisions about technology should answer a republican question: what kind of public world should we create through technology? Democratizing Technology deserves to be read widely. John ONeill, Professor of Political Economy, University of Manchester, UK A welcome addition to the new, more empirical and applied literature in philosophy of technology. This book will be essential reading for a variety of scholars and for the general reader intent on understanding, and criticizing, our chemically made world.Andrew Light, Interim Director, Program on the Environment, University of Washington, US What is technology? How do humans use it to build and modify the world? What are the relationships between technology, science, economics and democratic governance? What, if any, are our ethical and political responsibilities and choices in how we develop, deploy and control technology in democratic states? Democratizing Technology sets out to answer these questions. Focusing on the most widespread and pervasive technology - chemicals - this groundbreaking volume peels apart the critical technology debate to look at the relationship between humans, technology and the biological world. Attention is given to the immensely important new regulations, REACH (Registration, Evaluation, Authorization and restriction of Chemicals), the EUs largest ever legal framework, discussing the problems that are likely to occur in REACHs reliance on risk assessment methods and suggesting an alternative way forward for the regulation of chemicals. Providing much-needed clarity and insight into the heart of key debates in science and technology, risk analysis and mitigation, and domestic and international law, this volume arrives as a breath of fresh air.

The book provides an integrated energy/exergy analysis method to identify the energy utilization issues and systematically propose the cost-effective energy-saving and CO2 mitigation/capture solution. There is a strong market needs on energy-saving and greenhouse gas (GHG) reduction. CO2 mitigation/capture will achieve economic benefit of fuel, power, and carbon tax saving as well as environmental GHG reduction. The book is a professional book for energy-saving and GHG gas mitigation technology in oil & gas, oil refining, and chemical industry. It is an integrated technical book that combines energy utilization theory and practical method, including: thermodynamic analysis for unit operation and process units; energy and exergy calculation for various process streams and utilities; three-link energy/exergy analysis model; energy/exergy balance of equipment, process units, and entire plant; approach and technology of energy saving; optimization of pipeline and equipment; pinch energy-saving technology and its application; CO2 capture and utilization with 8 case studies incorporated for all different scenarios; key energy-saving technologies such gas turbine, FCCU regeneration CO combustion and energy recovery, flue gas turbine system optimization, low-grade heat recovery and utilization. The book is intended for engineers and professional personnel who are working in process engineering, EPC companies, chemical and petrochemical plants, refineries, oil & gas production facilities, power generation plant. It can also be a professional reference or textbook for undergraduate or graduate-level university students and teaching personnel of chemical, energy, and process engineering faculties of universities.

Written by an experienced professional, the book introduces chemists to process development, using examples from the pharmaceutical, agrochemical and fragrance industries. The focus is on small molecules rather than biomolecules, and on relatively small-scale production rather than bulk petrochemicals. The coverage is broad, going from initial route development, through pilot plant operations, to full-scale production.

Featuring extensive calculations and examples, this reference discusses theoretical and practical aspects of short-circuit currents in ac and dc systems, load flow, and harmonic analyses to provide a sound knowledge base for modern computer-based studies that can be utilized in real-world applications. Presenting more than 2300 figures, tables, and equations, the author explores matrix methods for network solutions and includes load flow and optimization techniques. He discusses ac and dc short-circuit systems calculations in accordance with standards set by the American National Standards Institute (ANSI) and the International Electrotechnical Commission (IEC).

Modern biotechnology - the controversial manipulation of genes in living organisms - has far-reaching implications for agriculture, human health, trade and the environment. Against the odds, an international treaty governing biosafety and trade in biotechnology was adopted in 2000. The Cartagena Protocol on Biosafety of the Convention on Biological Diversity deals with one of the most important and challenging issues thrown up by developments in biotechnology. This volume is a comprehensive review of the protocol and the process that led to its adoption. It includes contributions from many of the key players involved and analyses the commercial and political interests at stake, the operations and implications of the protocol, and prospects for the future.