On the night of December 2, 1943, the Luftwaffe bombed a critical Allied port in Bari, Italy, sinking seventeen ships and killing over a thousand servicemen and hundreds of civilians. Caught in the surprise air raid was the John Harvey, an American Liberty ship carrying a top-secret cargo of 2,000 mustard bombs to be used in retaliation if the Germans resorted to gas warfare. After young sailors began suddenly dying with mysterious symptoms, Lieutenant Colonel Stewart Alexander, a doctor and chemical weapons expert, was dispatched to investigate. He quickly diagnosed mustard gas exposure, which Churchill denied. Undaunted, Alexander defied British officials and persevered with his investigation. His final report on the Bari casualties was immediately classified, but not before his breakthrough observations about the toxic effects of mustard on white blood cells caught the attention of Colonel Cornelius P. Rhoads - a pioneering physician and research scientist as brilliant as he was arrogant and self-destructive - who recognized that the poison was both a killer and a cure, and ushered in a new era of cancer research. Deeply researched and beautifully written, The Great Secret is the remarkable story of how horrific tragedy gave birth to medical triumph.

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics.