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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Chemotherapy
The second edition of Oncology Clinical Trials has been thoroughly
revised and updated and now contains the latest designs and methods
of conducting and analyzing cancer clinical trials in the era of
precision medicine with biologic agents-including trials
investigating the safety and efficacy of targeted therapies,
immunotherapies, and combination therapies as well as novel
radiation therapy modalities. Now divided into five sections this
revamped book provides the necessary background and expert guidance
from the principles governing oncology clinical trials to the
innovative statistical design methods permeating the field; from
conducting trials in a safe and effective manner, analyzing and
interpreting the data, to a forward-looking assessment and
discussion of regulatory issues impacting domestic, international,
and global clinical trials. Considered by many as the gold standard
reference on oncology clinical trials in the field, the second
edition continues to provide examples of real-life flaws and
real-world examples for how to successfully design, conduct and
analyze quality clinical trials and interpret them. With chapters
written by oncologists, researchers, biostatisticians, clinical
research administrators, and industry and FDA representatives, this
volume provides a comprehensive guide in the design, conduct,
monitoring, analysis, and reporting of clinical trials in oncology.
New to this Edition: Outlines how to design clinical trials with
and without biomarker testing-including genomics-based "basket"
trials, and adaptive trials for all phases during treatment and
quality-of-life trials Includes new chapters on immunotherapy
trials, radiation therapy trials, multi-arm trials, meta-analysis
and adaptive design, use of genomics, dose modifications and use of
ancillary treatments in investigational studies, establishing
surrogate endpoints, practical issues with correlative studies,
cost-effectiveness analysis, and more Comprehensively covers all
regulatory aspects in the pursuit of global oncology trials Digital
Access to the eBook included
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Precision Radiation Oncology
(Paperback)
Bruce G. Haffty, Sharad Goyal; Contributions by Sanjay Aneja, Randall J. Kimple, Zachary S. Morris, …
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R3,102
Discovery Miles 31 020
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Ships in 12 - 19 working days
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Precision medicine is a rapidly-evolving field in the management of
cancer. The use of novel molecular or genetic signatures in
local-regional management is still in its infancy. Precision
Radiation Oncology demystifies this state-of-the-art research and
technology. By describing current existing clinical and pathologic
features, and focusing on the ability to improve outcomes in cancer
using radiation therapy, this book discusses incorporating novel
genomic- or biology-based biomarkers in the treatment of patients
moving radiation oncology into precision/personalized medicine.
Precision Radiation Oncology provides readers with an overview of
the new developments of precision medicine in radiation oncology,
further advancing the integration of new research findings into
individualized radiation therapy and its clinical applications.
Drug resistance in cancer, whereby a proportion of cancer cells
evades chemotherapy, poses a profound and continuing challenge for
the effective treatment of cancer. The principles underlying the
biological mechanisms behind this phenomenon are clearly understood
and explained in this volume. However, a deeper understanding of
drug resistance requires a quantitative appreciation of the dynamic
forces that shape tumour growth, including spontaneous mutation and
selection processes. The authors seek to explain and to simplify
these complex mechanisms, and to place them in a clinical context.
Clearly explained mathematical models are used to illustrate the
biological principles and provide an insight into tumour
development and the effectiveness and limitations of drug
treatment. It is suitable for those with a non-mathematical
background and aims to enhance the effectiveness of cancer therapy.
The development of drug-resistant cancers is considered to be the
most significant obstacle to the cure of cancer today. Nearly half
of all patients with cancer suffer from tumours that are
intrinsically resistant to chemotherapy, and most of the remaining
half develop drug resistance during the course of their treatment.
This book reviews the mechanisms and clinical implications of drug
resistance in cancer with unrivalled authority. Chapters cover
topics of current clinical concern, including multiple drug
resistance and its reversal, topoisomerase drugs, apoptosis, dose
intensity and escalation, gene therapy and haematopoietic support.
The authors are among the leading clinicians and investigators in
the field. These authoritative volumes in this series are intended
for a wide audience of clinicians and researchers with an interest
in the applications of biomedical science to the understanding and
management of cancer.
This second edition of the Oxford Handbook of Cancer Nursing is an
essential aid to the practising cancer nurse. It provides a quick
reference to the key issues in cancer nursing, and a concise and
systematic account of all of the main areas of cancer nursing
practice. Filled with key tips and reflection points, each chapter
supports professional development for the reader. The patient,
their family, and the experience of cancer are at the heart of this
handbook. For the new edition there is a greater focus on
survivorship, drawing on recent developments in the area. The
Oxford Handbook of Cancer Nursing promotes a multidisciplinary
approach to cancer care, with references to current best evidence
and the latest developments in treatment. Detailed guidance on
complex aspects of care are outlined, integrating both psychosocial
and physical care to better treat the whole patient. Written by
experienced nurses, the book is laid out to enable quick access to
precise, targeted information on the vast majority of potential
clinical scenarios.
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I Don't
(Paperback)
Colleen Hofstadter Hlavac
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R201
Discovery Miles 2 010
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Ships in 10 - 15 working days
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