The liver is a vital organ involved in numerous metabolic processes such as cholesterol and bile acid metabolism, biliary lipid secretion, and bile formation. Cholesterol balance across the liver has a crucial effect on influencing plasma total and LDL cholesterol levels and biliary cholesterol concentrations. Cholesterol and bile acid biosyntheses are primarily modulated by negative feedback regulatory mechanisms through the sterol regulatory element-binding protein isoform 2 (SREBP-2) and the farnesoid X receptor (FXR) pathways, respectively. The conversion of cholesterol to bile acids in the liver can balance the fecal excretion of bile acids, which is an important route for the removal of cholesterol from the body. Bile formation begins in the bile canaliculi, and maintenance of the enterohepatic circulation of bile acids results in a continuous secretion of bile. Hepatic secretion of biliary lipids is determined mainly by a group of ATP-binding cassette (ABC) transporters that are located on the canalicular membrane of hepatocytes, which are regulated by various nuclear receptors. Bile acids promote bile flow by their osmotic effects. Also, they are essential for the intestinal absorption of cholesterol, fatty acids, and fat-soluble vitamins and play an important role in aiding the digestion of dietary fat. Bile acids function as signaling molecules and anti-inflammatory agents to regulate lipid, glucose, and energy metabolism by rapidly activating nuclear receptors and cell signaling pathways. This eBook summarizes the progress in the molecular and cellular mechanisms of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system.

'Light' from low level laser therapy, through a process called photobiomodulation (PBM), has been in existence in supportive care in cancer, in particular in the management of oral mucositis (OM) in patients undergoing chemotherapy, radiation therapy and haematopoietic stem cell transplantation. In this book the authors attempt to portray the current status of the supportive care interventions that are possible with PBM using low level laser therapy (LLLT) in patients undergoing cancer treatment for solid tumours, harmatological malignancies, and head and neck cancers.

Beth Kaufman's Stand-up Guide to Surviving Breast Cancer This book can help people keep a sense of humor through cancer treatment even on the worst days. This is a great book for newly diagnosed patients, caregivers and survivors alike. This is Beth's personal story of her bout with breast cancer. It is told with humor, yet is poignant. It takes you on a year-long ride from start to finish. You will laugh, you will cry, and you will certainly get your yearly mammograms after reading her story. It is unique in the way it is told from a comedienne's point of view, a stand up guide to getting through 525,600 minutes of a cancer patient's life. Use this book as your "stand up" guide to surviving breast cancer.

Captain Chemo is the first of the Childhood Disease Series. In a child's terms, the book explains how chemotherapy works according to Captain Chemo and the Chemo Team. First the IV drips into the veins. Next the veins are filled with blood. The blood cells stand in formation Finally, Captain Chemo leads the team throughout the body looking for any Cancer Monsters that may be hiding between the beats of the heart or hanging with some dusty memories stored in the brain's library. With Captain Chemo on your side, you are never alone. Everyone is welcome to join and fight on Team Chemo. Onward March