"Progress in Molecular Biology and Translational Science" provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases.

Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.
Contributions from leading authorities Informs and updates on all the latest developments in the field

This book is an excellent resource for scientists, political decision makers, and students interested in the impact of peatlands on climate change and ecosystem function, containing a plethora of recent research results such as monitoring-sensing-modeling for carbon-water flux/storage, biodiversity and peatland management in tropical regions. It is estimated that more than 23 million hectares (62 %) of the total global tropical peatland area are located in Southeast Asia, in lowland or coastal areas of East Sumatra, Kalimantan, West Papua, Papua New Guinea, Brunei, Peninsular Malaysia, Sabah, Sarawak and Southeast Thailand. Tropical peatland has a vital carbon-water storage function and is host to a huge diversity of plant and animal species. Peatland ecosystems are extremely vulnerable to climate change and the impacts of human activities such as logging, drainage and conversion to agricultural land. In Southeast Asia, severe episodic droughts associated with the El Nino-Southern Oscillation, in combination with over-drainage, forest degradation, and land-use changes, have caused widespread peatland fires and microbial peat oxidation. Indonesia's 20 Mha peatland area is estimated to include about 45-55 GtC of carbon stocks. As a result of land use and development, Indonesia is the third largest emitter of greenhouse gases (2-3 Gtons carbon dioxide equivalent per year), 80 % of which is due to deforestation and peatland loss. Thus, tropical peatlands are key ecosystems in terms of the carbon-water cycle and climate change.

Interactions between species are of fundamental importance to all living systems and the framework we have for studying these interactions is community ecology. This is important to our understanding of the planets biological diversity and how species interactions relate to the functioning of ecosystems at all scales. Species do not live in isolation and the study of community ecology is of practical application in a wide range of conservation issues. The study of ecological community data involves many methods of analysis. In this book you will learn many of the mainstays of community analysis including: diversity, similarity and cluster analysis, ordination and multivariate analyses. This book is for undergraduate and postgraduate students and researchers seeking a step-by-step methodology for analysing plant and animal communities using R and Excel. Microsoft's Excel spreadsheet is virtually ubiquitous and familiar to most computer users. It is a robust program that makes an excellent storage and manipulation system for many kinds of data, including community data. The R program is a powerful and flexible analytical system able to conduct a huge variety of analytical methods, which means that the user only has to learn one program to address many research questions. Its other advantage is that it is open source and therefore completely free. Novel analytical methods are being added constantly to the already comprehensive suite of tools available in R. Mark Gardener is both an ecologist and an analyst. He has worked in a range of ecosystems around the world and has been involved in research across a spectrum of community types. His knowledge of R is largely self-taught and this gives him insight into the needs of students learning to use R for complicated analyses.

This book indicates the most optimal solutions for the growing civilization problem related to climate change that takes place more and more rapidly on our planet. It is divided into two parts: In the first part, the authors - based on the available analyses and reports on climate change taking place on Earth - present their own point of view in relation to the above issue, while trying to find answers to the following questions: * Why is it so difficult to admit that humans are responsible for the ongoing climate change? * Will climate change destroy life on Earth? * Can science and modern technologies stop this process? In the second part of the book, the authors propose a solution for the advancing climate change, regarding the reduction of CO2 emissions coming mainly from the energy sector. On the basis of scientific achievements and implementations of research institutions in Poland, especially the Institute of Fluid-Flow Machinery of the Polish Academy of Sciences in Gdansk, the book proposes directions of development of the energy transformation in Poland and other countries for which fossil fuels currently make a large contribution to the energy production process and are the main emitter of CO2 to the atmosphere. The book is addressed to citizens, ecologists, climatologists as well as politicians and experts responsible for shaping the climate and energy policy of the country level and also the world.

In the marine environment, single-celled, microscopic, plant-like organisms naturally occur in the well-lit surface layer of any body of water. These organisms, referred to as phytoplankton or microalgae, form the base of the food web upon which nearly all other marine organisms depend. Algal bloom is a rapid increase in or accumulation of the population of about 300 species of algae due to excess nutrients (eutrophication), and is of major global interest as it causes reduction in species diversity, abrupt changes in water quality, and discoloration of the water (green, yellow, brown or red) depending on the species of algae and the type of pigments they contain. Dying blooms can also be an environmental concern as when the cells sink and decay, bacteria break down the organic material, which in turn strips oxygen from the water. This microbial oxygen demand at times leads to very low oxygen levels in the bottom waters, harming aquatic life. Documentation of this sporadic high abundance of algae, together with the significant species richness of the diatoms, requires comprehensive studies in the Sundarban coastal environment, which is facing severe degradation due to natural & anthropogenic stressors. In addition, a better understanding of the effects of algal blooms on seafood quality, the complex biological, chemical and physical interactions and subsequent effects on trophodynamics is needed to develop strategies for effective coastal zone management. The book discusses the occurrence of harmful algal blooms (HABs) caused by the dinoflagellates of the genus Alexandrium and Karenia, or diatoms of the genus Pseudo-nitzschia, which have large and varied impacts on marine ecosystems (such as large-scale marine mortality events that have been associated with various types of shellfish poisonings) depending on the species involved, the environment where they are found, and the mechanism by which they exert negative effects. HABs represent a major environmental problem in all regions of the U.S., and their occurrence is on the rise due to increased nutrient pollution. HABs have severe impacts on human health, aquatic ecosystems, and the economy. Such blooms, known colloquially as red tides due to their red or brown hues, are increasing in frequency and magnitude worldwide as a result of changes in oceanic climate, increased coastal eutrophication and enhanced long-distance dispersal in ballast water. As such, the book offers an in-depth account of the complex biological, chemical and physical interactions of the algal blooms (both innocuous and harmful ones). It also discusses the highly topical issue of the impact of global climate change on the frequency and severity of HABs in the context of alterations in temperature, stratification, light and ocean acidification. Focusing on both basic and applied limnology, this book is a reliable and up-to-date reference resource for students, teachers and researchers engaged in the field of coastal research/management at regional and global scales.

This contributed volume provides insights into multiple applications using microbes to promote productivity in agriculture, to produce biochemicals or to respond to challenges in biomedicine. It highlights the microbial production of nanocompounds with medical functionality alongside new anti-mycobacterial strategies, and introduces plant-growth-promoting Rhizobacteria as well as the correlation between biofilm formation and crop productivity. Further, the authors illustrate the green synthesis of biochemical compounds, such as hydroxamid acid or biosurfactants, using microbial and fungal enzymes. It inspires young researchers and experienced scientists in the field of microbiology to explore the combined use of green, white and red biotechnology for industrial purposes, which will be one of the central topics for future generations.

This book provides an up-to-date coverage of green (vegetated) roof research, design, and management from an ecosystem perspective. It reviews, explains, and poses questions about monitoring, substrate, living components and the abiotic, biotic and cultural aspects connecting green roofs to the fields of community, landscape and urban ecology. The work contains examples of green roof venues that demonstrate the focus, level of detail, and techniques needed to understand the structure, function, and impact of these novel ecosystems. Representing a seminal compilation of research and technical knowledge about green roof ecology and how functional attributes can be enhanced, it delves to explore the next wave of evolution in green technology and defines potential paths for technological advancement and research.

This book investigates soil ecology and biodiversity for its ability to maintain a balance of beneficial organisms to support plant growth. This subject is discussed by a group of international authors in natural, agricultural and urban systems. The importance of biodiversity per se and, specifically, the feedbacks between the plant and soil biota in mediating soil function are emphasized. Examples are selected from allelopathy and invasive plant species along with the, hitherto overlooked, role of viruses in soil. The book is intended to provide a framework for a holistic understanding of the essential role of soil organisms in promoting plant growth.

This book analyses the state of the natural environment and the causes of its degradation using the biosphere approach. Further, those issues that must be resolved immediately on the global level are identified following the ideas defined by V.I. Vernadsky, and new principles of Man-Nature interaction are pursued. The modern world currently faces three global trends inducing biosphere degradation and the aggravation of ecological hazards, namely: a) rapid and uncontrolled growth of human population on the Earth and insufficient natural resources to sustain it; (b) technogenesis development; and (c) global climate change and the aggravation of natural disasters. Ecological safety and military security are becoming the crucial conditions for the survival of modern civilization. To mitigate the ecological strain on the Earth, the technogenesis strategy should be changed and many other pressing issues must be resolved. These problems should be addressed using the biosphere approach, because the individual human being is the biosphere constituent, and his or her safety cannot be provided without maintaining the entire natural system on our planet.

This book reviews and assesses the various methodologies for site characterization and site effect estimation to carry out seismic zonation at micro and macro levels. Readers will learn about the suitability of these methodologies for each level of zoning that needs to be assessed in order to optimize the resources for carrying out seismic zonation. The Indian sub-continent is highly vulnerable to earthquake hazards, and past studies have focused primarily on the Himalayan region (inter-plate zone) and the northeast region (subduction zone). The book improves understanding of the Peninsular India that also has significantly high seismicity and is prone to earthquakes of sizeable magnitude. Particular attention is given to the various methodologies for assessing seismic hazards, the scales at which site characterizations are carried out, and optimal methods for zonation practices using site data and hazard indexes. Aimed at students, this book will be of use to post-graduates and doctoral students researching seismic zonation, hazard assessment and mitigation, and spatial data in earth sciences.

This book features articles that analyze current agricultural issues and knowledge. It also proposes novel, environmentally friendly solutions that are based on integrated information from such fields as agronomy, soil science, molecular biology, chemistry, toxicology, ecology, economics and the social sciences.Coverage examines ways to produce food and energy in a sustainable way for humans and their children. Inside, readers will find articles that explore climate change, increasing food and fuel prices, poor-nation starvation, rich-nation obesity, water pollution, soil erosion, fertility loss, pest control and biodiversity depletion. Instead of solving problems using the classical painkiller approach, which seeks to limit negative impacts, sustainable agriculture treats challenges at their source. Because most societal issues are in fact intertwined, global, and fast-developing, sustainable agriculture will bring solutions that have the potential to build a more peaceful world. This book will help scientists, decision-makers, professors, farmers and politicians build safer agriculture, energy and food systems for future generations.

This book provides an interpretative analysis of the notion of spirituality through the lens of contemporary performance and posthuman theories. The book examines five performance/artworks: The Artist is Present (2010) by Marina Abramovic; The Deer Shelter Skyscape (2007) by James Turrell; CAT (1998) by Ansuman Biswas; Journey to the Lower World by Marcus Coates (2004); and the work with pollen by Wolfgang Laib. Through the analysis of these works the notion of spirituality is grounded in materiality and embodiment allowing the conceptual juxtaposition of spirit and matter to introduce the paradoxical as the guiding thread of the narrative of the book. Here, the human is interrogated and negotiated with/within a plurality of other living organisms, intangible existences and micro and macrocosmic ecologies. Silence, meditation, shamanic journeys, reciprocal gazing, restraint, and contemplation are analyzed as technologies used to manipulate perception and adventure into the multilayered condition of matter.

Wetlands are among the world's most valuable and most threatened habitats, and in these crucially important ecosystems, the invertebrate fauna holds a focal position. Most of the biological diversity in wetlands is found within resident invertebrate assemblages, and those invertebrates are the primary trophic link between lower plants and higher vertebrates (e.g. amphibians, fish, and birds). As such, most scientists, managers, consultants, and students who work in the world's wetlands should become better informed about the invertebrate components in their habitats of interest. Our book serves to fill this need by assembling the world's most prominent ecologists working on freshwater wetland invertebrates, and having them provide authoritative perspectives on each the world's most important freshwater wetland types. The initial chapter of the book provides a primer on freshwater wetland invertebrates, including how they are uniquely adapted for life in wetland environments and how they contribute to important ecological functions in wetland ecosystems. The next 15 chapters deal with invertebrates in the major wetlands across the globe (rock pools, alpine ponds, temperate temporary ponds, Mediterranean temporary ponds, turloughs, peatlands, permanent marshes, Great Lakes marshes, Everglades, springs, beaver ponds, temperate floodplains, neotropical floodplains, created wetlands, waterfowl marshes), each chapter written by groups of prominent scientists intimately knowledgeable about the individual wetland types. Each chapter reviews the relevant literature, provides a synthesis of the most important ecological controls on the resident invertebrate fauna, and highlights important conservation concerns. The final chapter synthesizes the 15 habitat-based chapters, providing a macroscopic perspective on natural variation of invertebrate assemblage structure across the world's wetlands and a paradigm for understanding how global variation and environmental factors shape wetland invertebrate communities.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Adaptive management is an approach to managing social-ecological systems that fosters learning about the systems being managed and remains at the forefront of environmental management nearly 40 years after its original conception. Adaptive management persists because it allows action despite uncertainty, and uncertainty is reduced when learning occurs during the management process. Often termed "learning by doing", the allure of this management approach has entrenched the concept widely in agency direction and statutory mandates across the globe. This exceptional volume is a collection of essays on the past, present and future of adaptive management written by prominent authors with long experience in developing, implementing, and assessing adaptive management. Moving forward, the book provides policymakers, managers and scientists a powerful tool for managing for resilience in the face of uncertainty.

Volume 7, devoted to the vital and rapidly expanding research area around metal-carbon bonds (see also MILS-6), focuses on the environment. With more than 2500 references, 35 tables, and nearly 50 illustrations, many of these in color, it is an essential resource for scientists working in the wide range from organometallic chemistry, inorganic biochemistry, environmental toxicology all the way through to physiology and medicine. In 14 stimulating chapters, written by 29 internationally recognized experts, Organometallics in Environment and Toxicology highlights in an authoritative and timely manner environmental cycles of elements involving organometal(loid) compounds as well as the analytical determination of such species. This book examines methane formation involving the nickel coenzyme F430, as well as the organometal(loid) compounds formed by tin, lead, arsenic, antimony, bismuth, selenium, tellurium, and mercury. In addition, it deals with the environmental bioindication, biomonitoring, and bioremediation of organometal(loid)s, and it terminates with methylated metal(loid) species occurring in humans by evaluating assumed and proven health effects caused by these compounds.

A new way of measuring the health of a political system: by examining the health of its landscapes and ecosystems East Germany, its economy, and its society were in decline long before the country's political collapse in the late 1980s. The clues were there in the natural landscape, Arvid Nelson argues in this groundbreaking book, but policy analysts were blind to them. Had they noted the record of the leadership's values and goals manifest in the landscape, they wouldn't have hailed East Germany as a Marxist-Leninist success story. Nelson sets East German history within the context of the landscape history of two centuries to underscore how forest and ecosystem change offered a reliable barometer to the health and stability of the political system that governed them. Cold War Ecology records how East German leaders' indifference to human rights and their disregard for the landscape affected the rural economy, forests, and population. This lesson from history suggests new ways of thinking about the health of ecosystems and landscapes, Nelson shows, and he proposes assessing the stability of modern political systems based on the environment's system qualities rather than on political leaders' goals and beliefs.

This contributed volume sheds new light on waste management and the production of biofuels. The authors share insights into microbial applications to meet the challenges of environmental pollution and the ever- growing need for renewable energy. They also explain how healthy and balanced ecosystems can be created and maintained using strategies ranging from oil biodegration and detoxification of azo dyes to biofouling. In addition, the book illustrates how the metabolic abilities of microorganisms can be used in microbial fuel-cell technologies or for the production of biohydrogen. It inspires young researchers and experienced scientists in the field of microbiology to explore the application of green biotechnology for bioremediation and the production of energy, which will be one of the central topics for future generations.

Dynamic Food Webs challenges us to rethink what factors may determine ecological and evolutionary pathways of food web development. It touches upon the intriguing idea that trophic interactions drive patterns and dynamics at different levels of biological organization: dynamics in species composition, dynamics in population life-history parameters and abundances, and dynamics in individual growth, size and behavior. These dynamics are shown to be strongly interrelated governing food web structure and stability and the role of populations and communities play in ecosystem functioning.
Dyanmic Food Webs not only offers over 100 illustrations, but also contains 8 riveting sections devoted to an understanding of how to manage the effects of environmental change, the protection of biological diversity and the sustainable use of natural resources.
Dyanmic Food Webs is a volume in the "Theoretical Ecology" series.
* Relates dynamics on different levels of biological organization: individuals, populations, and communities
* Deals with empirical and theoretical approaches
* Discusses the role of community food webs in ecosystem functioning
* Proposes methods to assess the effects of environmental change on the structure of biological communities and ecosystem functioning
* Offers an analyses of the relationship between complexity and stability in food webs

This is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.

This book offers new perspectives of transdisciplinary research, in methodological as well as theoretical respects. It provides insights in the two-fold bio-physical and the socio-cultural global embeddedness of local living conditions on the basis of selected empirical studies from Latin America, Asia, Africa, Australia and Europe. The theoretical foundations of ecological research and sustainability policies were developed at the end of the nineteenth century. They are largely based on investigations of living spaces and the evolution and differentiation of varied life forms. This perspective is embedded in the practical and theoretical European problem situations of the past and lacks social and cultural differentiation. The transformation of spatial and natural relations as a result of the globalization process is so radical that new theories are needed to solve 21st century ecological problems. Moreover, in view of the lack of an ontologically sound and promising strategy for transdisciplinary problem solving, as well as an acceptable consideration of the power of cultural schemas relating to natural living's interpretations, there is a strong need to focus on sustainable social practices, habits and routines, rather than on predominantly living spaces or eco-topes. This book elaborates on the transdisciplinary approach by reflecting on the theoretical heritage and a global perspective of sustainability, by focusing on the primary role of a social approach in sustainability research and by putting emphasis on cultural dimension of sustainability. It postulates that global sustainability is grounded in a global understanding of our everyday activities.

Modern industrial agriculture is not sustainable because of its heavy reliance on petroleum, a non-renewable source of the energy used in farming, and because of pollution caused by petroleum products such as fertilizers and pesticides. A systems analysis of farming suggests that agriculture will be more sustainable when services of nature, such as nutrient recycling by soil micro-organisms and natural controls of insects, replace the services now provided by energy from petroleum. Examples are drawn from the Southeastern USA, but lessons learned can be applied worldwide.

This book describes various aspects of modern microbiology including microbial enzymes, secondary metabolites, next-generation sequencing, microbial-based biopesticides, microbial-based cancer therapies, biodiesel, and microbial products from fermentation, biodegradation, bioremediation and wastewater treatment. Further, it explains how and why microbes play an important role in preserving the welfare of living beings and the environment. Many bacteria play a significant part in cleaning our environment by detoxifying various xenobiotic compounds, while several microbes produce secondary metabolites that are useful to human beings. The book is divided into 15 chapters that cover various aspects of microorganism-based biotechnology, including recent methodologies such as advanced molecular techniques, as well developments in classical microbiological techniques. The authors also explain how the latest and classical techniques are being used in modern-day microbial biotechnology. All chapters were written by experts from prominent universities, research laboratories, and institutes around the globe. Above all, they focus on recent advances in microbial technology that promote the welfare of living beings and the environment.

This book focuses on climate change and sustainable development, showcasing examples of research, projects and other initiatives aimed at educating various target groups. Helping readers gain a better understanding of the water, energy and food nexus challenges in the context of climate change, and featuring valuable insights that can be implemented in other areas, it will appeal to researchers and students as well as practitioners.