Locard’s Exchange Principle underpins all forensic science and holds that the perpetrator of a crime will bring something to the crime scene and leave with something from it.

Forensic experts use this principle daily to catch murderers and assailants. In Risking Life for Death, South African forensic pathologist Ryan Blumenthal offers a master class in this singular forensic technique based on real-life case studies. With more than twenty years’ experience in the field, Blumenthal explains how to look for clues and traces, and how what he does not find at autopsy is often more important than what he does find. In other words, the absence of evidence can sometimes be of greater value than the presence of evidence.

His account also highlights the dangers forensic pathologists are exposed to daily. As they try to unravel the puzzle of someone’s death, forensic pathologists often face life-threatening infections, toxic gases and the hazards associated with high-profile cases – in effect, risking their life to solve someone else’s death.

An understanding of Locard’s Exchange Principle can help you become a medical detective in your own life, can help you be a happier person and can even provide you with a better philosophy for growing older, Blumenthal argues.

Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre. Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question. Key points Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings

A likeable young girl who’s burnt her family home to the ground.
A man with no memory of the night he killed his wife.
A teenager whose visions and voices have had murderous effect.

One question binds these and others from the casebook of Britain’s leading forensic psychiatrist: Why?

What drives a person to commit seemingly inexplicable crimes?

Dr Duncan Harding is the person the police and the courts turn to for answers. An expert witness, he must try to establish a defendant’s mental state and motivation. And their fitness to stand trial.

Growing up in a broken, violent home, Harding became a doctor because he wanted to be good and kind. It led him on a journey that has brought him face to face with psychopaths, taken him to the limits of his compassion and to the darkest corners of his own troubled past.

But he’s never turned away nor given up hope.

This new edition provides trainees with a comprehensive review of cytopathology, presented as multiple choice questions with answers and detailed explanatory notes. Divided into twelve chapters, the book covers different body systems including the respiratory tract, breast, thyroid, lymph nodes, liver, gastrointestinal tract, and much more. Each topic covers key aspects of modern cytopathology including diagnostic criteria, reporting systems, ancillary testing modalities, molecular mechanisms of diseases, and clinico-pathological correlations. All chapters have been fully updated and questions are in line with those trainees may encounter in American Board of Pathology examinations. Key learning points are summarised at the end of each topic. Authored by renowned pathologist Fang Fan from City of Hope Medical Centre, California, the third edition of this book is highly illustrated with clinical images and figures. The previous edition (9789352700462) published in 2017.

Forensic Genetic Approaches for Identification of Human Skeletal Remains: Challenges, Best Practices, and Emerging Technologies provides best practices on processing bone samples for DNA testing. The book outlines forensic genetics tools that are available for the identification of skeletal remains in contemporary casework and historical/archaeological investigations. Although the book focuses primarily on the use of DNA for direct identification or kinship analyses, it also highlights complementary disciplines often used in concert with genetic data to make positive identifications, such as forensic anthropology, forensic odontology, and forensic art/sculpting. Unidentified human remains are often associated with tragic events, such as fires, terrorist attacks, natural disasters, war conflicts, genocide, airline crashes, homicide, and human rights violations under oppressive totalitarian regimes. In these situations, extensive damage to soft tissues often precludes the use of such biological samples in the identification process. In contrast, bone material is the most resilient, viable sample type for DNA testing. DNA recovered from bone often is degraded and in low quantities due to the effects of human decomposition, environmental exposure, and the passage of time. The complexities of bone microstructure and its rigid nature make skeletal remains one of the most challenging sample types for DNA testing.

Now fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what's new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.Key features of this practical text include:  A consistent, user-friendly format that explores each entity's clinical features, gross and microscopic findings, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations.  A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses.  Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis.  Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout.  Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.  What's NEW in this edition:  Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine.  New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.  The latest TNM staging and WHO classification systems.  New co-editors Drs. Amitabh Srivastava and Daniela S. Allende lead a team of expert, internationally recognized pathologists who keep you up to date with the latest information in the field. 

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

Toxicological and pharmacological effects arise when chemicals interact with biophysical functions in discrete cell types. Researchers have a continuing need to screen novel compounds for their potential therapeutic needs and, once these have been discovered, to understand their molecular actions. Histochemistry can be used to facilitate the development of the knowledge on the distribution of a compound, the receptors to which it binds and the modulation of the physiological functions that are being investigated.

Presenting pathophysiology through the lens of body function, Applied Pathophysiology: A Conceptual Approach, 4th Edition, goes beyond memorization of facts to give students a thorough understanding of altered human function and a practical framework for applying concepts in clinical settings. By helping students understand that diseases are rarely confined to one body system, this novel approach conditions students to think like practitioners, working from symptom to cause to build an understanding of the disease process essential to successful practice.    Supported by the latest clinical practices and research-based evidence, this 4th Edition has been updated to prepare students for today’s changing healthcare environment. Engaging features and resources throughout the text emphasize active learning strategies and challenge students to apply their knowledge to a wide range of diseases.    

Die Verfasser der verschiedenen Unterkapitel im vorliegenden Band »Urogenitale und Endokrine Organe, Gelenke und Skelett« sind führende Pathologen der Arbeitskreise, die sich mit den genannten Themen diagnostisch und wissenschaftlich beschäftigen. Bei der Darstellung der Erkrankungen wird das gesicherte Wissen unter Einarbeitung der bedeutsamen aktuellen Entwicklungen wiedergegeben. Insbesondere werden neue Terminologien, Klassifikationen, immunhistologische Befunde und molekulare Charakteristika dargestellt. Dies bedeutet, dass detailliert über die häufigen Erkrankungen gesprochen, dass aber auch über den »seltenen Fall« informiert wird. Insgesamt ist es das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit zu sein und dabei nicht nur Assistenzärzte in der Weiterbildung zum Pathologen oder Fachärzte für Pathologie, sondern auch Kliniker anzusprechen.

Offering expert, practical guidance through the decision-making process,Differential Diagnoses in Surgical Pathology: Gynecologic Tract, Second Edition, by Drs. Russell Vang, Anna Yemelyanova, and Jeffrey D. Seidman, helps you systematically solve tough diagnostic challenges in gynecologic pathology and arrive at a correct diagnosis between commonly confused entities. In this fully revised edition, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the authors emphasize atypical features that can complicate diagnoses.  Provides side-by-side comparisons for each major differential diagnosis—more than 170 in all— helping you distinguish between commonly confused lesions of the gynecologic tract  Contains more than 1,500 full-color photographs that depict the features of each entity and cover all major differential diagnoses in this challenging area  Offers up-to-date coverage of the vulva and vagina, cervix, endometrial epithelial lesions, uterine pure mesenchymal and mixed epithelial-mesenchymal lesions, the ovary, peritoneum/omentum, fallopian tube and paratubal region, and gestational trophoblastic disease  Ideal for practicing pathologists, pathologists in training, residents, and medical students    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

Illustrated with over 800 colour images, this practical guide covers the unique morphology and disease spectrum in pediatric patients, ranging from normal physiologic changes to pathologic states. In addition, it covers newly described pediatric diseases, such as GATA-2 haploinsufficiency and reflects the latest WHO classification for hematolymphoid neoplasms. With the visual format of an atlas, the book provides a quick reference for trainees and physicians in hematopathology, as well as for hematologists and oncologists treating pediatric patients. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

Elevated homocysteine is a powerful, independent risk factor in more than 100 major medical conditions, including heart disease, strokes, and Alzheimer's disease. The authors discuss factors that contribute to high homocysteine, tell how to detect it if it's too high, and explain how to dramatically lower it.

• Contributors are internationally known experts • Richly illustrated • Focuses on the differences of diagnostic methods between Japan and other countries by using endoscopic and pathologic pictures • For the first time, the Japanese progress in the field is published in English and made accessible to researchers worldwide

This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.