Locard’s Exchange Principle underpins all forensic science and holds that the perpetrator of a crime will bring something to the crime scene and leave with something from it.

Forensic experts use this principle daily to catch murderers and assailants. In Risking Life for Death, South African forensic pathologist Ryan Blumenthal offers a master class in this singular forensic technique based on real-life case studies. With more than twenty years’ experience in the field, Blumenthal explains how to look for clues and traces, and how what he does not find at autopsy is often more important than what he does find. In other words, the absence of evidence can sometimes be of greater value than the presence of evidence.

His account also highlights the dangers forensic pathologists are exposed to daily. As they try to unravel the puzzle of someone’s death, forensic pathologists often face life-threatening infections, toxic gases and the hazards associated with high-profile cases – in effect, risking their life to solve someone else’s death.

An understanding of Locard’s Exchange Principle can help you become a medical detective in your own life, can help you be a happier person and can even provide you with a better philosophy for growing older, Blumenthal argues.

Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre. Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question. Key points Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings

This new edition provides trainees with a comprehensive review of cytopathology, presented as multiple choice questions with answers and detailed explanatory notes. Divided into twelve chapters, the book covers different body systems including the respiratory tract, breast, thyroid, lymph nodes, liver, gastrointestinal tract, and much more. Each topic covers key aspects of modern cytopathology including diagnostic criteria, reporting systems, ancillary testing modalities, molecular mechanisms of diseases, and clinico-pathological correlations. All chapters have been fully updated and questions are in line with those trainees may encounter in American Board of Pathology examinations. Key learning points are summarised at the end of each topic. Authored by renowned pathologist Fang Fan from City of Hope Medical Centre, California, the third edition of this book is highly illustrated with clinical images and figures. The previous edition (9789352700462) published in 2017.

Illustrated with over 800 colour images, this practical guide covers the unique morphology and disease spectrum in pediatric patients, ranging from normal physiologic changes to pathologic states. In addition, it covers newly described pediatric diseases, such as GATA-2 haploinsufficiency and reflects the latest WHO classification for hematolymphoid neoplasms. With the visual format of an atlas, the book provides a quick reference for trainees and physicians in hematopathology, as well as for hematologists and oncologists treating pediatric patients. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.

Now fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what's new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.Key features of this practical text include:  A consistent, user-friendly format that explores each entity's clinical features, gross and microscopic findings, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations.  A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses.  Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis.  Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout.  Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.  What's NEW in this edition:  Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine.  New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.  The latest TNM staging and WHO classification systems.  New co-editors Drs. Amitabh Srivastava and Daniela S. Allende lead a team of expert, internationally recognized pathologists who keep you up to date with the latest information in the field. 

Highly Commended at the British Medical Association Book Awards 2016 Postgraduate Haematology provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style. * Up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of all blood disorders * New sections reflect advances in the specialty, including knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies * Superb four-color illustrations and photomicrographs of blood cells and tissues throughout * Includes algorithms to aid with decision-making for treatment * Companion website includes figures and tables for download

Recent Advances in Histopathology: 25 features a collection of in depth reviews of the latest developments in the field. Written in an accessible and easy to read format supplemented by a wealth of colour microphotographs, the book is authored by leading recognised experts. Much of Volume 25 focuses on COVID-19, describing its histopathologic manifestations in various organs and the mechanisms involved in the pathogenesis of the virosis. Other chapters discuss topics such as endocervical adenocarcinoma, cystic kidney tumours, and interstitial diseases of the lung. Each article provides a comprehensive overview, and emphasises the salient points of interest, with a ‘key clinical points for practice’ section concluding the chapter. This latest volume in the series is an invaluable resource for busy clinicians and those sitting FRCPath examinations.

Forensic Genetic Approaches for Identification of Human Skeletal Remains: Challenges, Best Practices, and Emerging Technologies provides best practices on processing bone samples for DNA testing. The book outlines forensic genetics tools that are available for the identification of skeletal remains in contemporary casework and historical/archaeological investigations. Although the book focuses primarily on the use of DNA for direct identification or kinship analyses, it also highlights complementary disciplines often used in concert with genetic data to make positive identifications, such as forensic anthropology, forensic odontology, and forensic art/sculpting. Unidentified human remains are often associated with tragic events, such as fires, terrorist attacks, natural disasters, war conflicts, genocide, airline crashes, homicide, and human rights violations under oppressive totalitarian regimes. In these situations, extensive damage to soft tissues often precludes the use of such biological samples in the identification process. In contrast, bone material is the most resilient, viable sample type for DNA testing. DNA recovered from bone often is degraded and in low quantities due to the effects of human decomposition, environmental exposure, and the passage of time. The complexities of bone microstructure and its rigid nature make skeletal remains one of the most challenging sample types for DNA testing.

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

Toxicological and pharmacological effects arise when chemicals interact with biophysical functions in discrete cell types. Researchers have a continuing need to screen novel compounds for their potential therapeutic needs and, once these have been discovered, to understand their molecular actions. Histochemistry can be used to facilitate the development of the knowledge on the distribution of a compound, the receptors to which it binds and the modulation of the physiological functions that are being investigated.

Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen's arrival in the department to preparation of the final report, you'll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review. Helps you find information quickly with a user-friendly design, concise paragraphs, numbered lists, and bulleted material throughout the text. Reflects the latest AJCC staging information, as well as updates throughout on reporting procedures, protocols, and safety. Offers detailed instructions on the dissection, description, and sampling of specimens, and explains the application of pathology reports to patient management. Provides procedures for new types of specimens including pulmonary image guided resections, endoscopic mucosal resection, endoscopic submucosal dissection, laparoscopic hysterectomy, or nephrectomy morcellation, vertical sleeve gastrectomy, and evaluation of breast implant capsules with a clinical suspicion of lymphoma Features dozens of illustrations that demonstrate the gross appearance of common pathologic lesions, and more than 150 tables that examine the interpretation of histochemical stains, immunohistochemical studies, electron microscopy findings, cytogenetic changes, and much more. Examines the specimens from every organ and system as well as bullets, medical devices, and foreign materials. Includes a new chapter on occupational hazards for pathologists ranging from visual and musculoskeletal problems to exposure and prevention of workplace acquired infection and cancer. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Offering expert, practical guidance through the decision-making process,Differential Diagnoses in Surgical Pathology: Gynecologic Tract, Second Edition, by Drs. Russell Vang, Anna Yemelyanova, and Jeffrey D. Seidman, helps you systematically solve tough diagnostic challenges in gynecologic pathology and arrive at a correct diagnosis between commonly confused entities. In this fully revised edition, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the authors emphasize atypical features that can complicate diagnoses.  Provides side-by-side comparisons for each major differential diagnosis—more than 170 in all— helping you distinguish between commonly confused lesions of the gynecologic tract  Contains more than 1,500 full-color photographs that depict the features of each entity and cover all major differential diagnoses in this challenging area  Offers up-to-date coverage of the vulva and vagina, cervix, endometrial epithelial lesions, uterine pure mesenchymal and mixed epithelial-mesenchymal lesions, the ovary, peritoneum/omentum, fallopian tube and paratubal region, and gestational trophoblastic disease  Ideal for practicing pathologists, pathologists in training, residents, and medical students    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

Die Verfasser der verschiedenen Unterkapitel im vorliegenden Band »Urogenitale und Endokrine Organe, Gelenke und Skelett« sind führende Pathologen der Arbeitskreise, die sich mit den genannten Themen diagnostisch und wissenschaftlich beschäftigen. Bei der Darstellung der Erkrankungen wird das gesicherte Wissen unter Einarbeitung der bedeutsamen aktuellen Entwicklungen wiedergegeben. Insbesondere werden neue Terminologien, Klassifikationen, immunhistologische Befunde und molekulare Charakteristika dargestellt. Dies bedeutet, dass detailliert über die häufigen Erkrankungen gesprochen, dass aber auch über den »seltenen Fall« informiert wird. Insgesamt ist es das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit zu sein und dabei nicht nur Assistenzärzte in der Weiterbildung zum Pathologen oder Fachärzte für Pathologie, sondern auch Kliniker anzusprechen.

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology, by Dr. Deborah L. Cook, helps you systematically solve tough diagnostic challenges in skin pathology and arrive at a correct diagnosis between commonly confused entities. In this all-new title, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the author emphasizes atypical features that can complicate diagnoses.  Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused non-neoplastic dermatopathology lesions  Contains more than 850 full-color photographs that depict the features of each entity and cover major differential diagnoses in this challenging area  Covers inflammatory disorders and alterations of the epidermis and dermis, blistering diseases, disorders of the adnexae and subcutis, infectious diseases, and more  Ideal for practicing pathologists, pathologists in training, residents, and medical students    Enrich Your eBook Reading Experience  Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech. 

Elevated homocysteine is a powerful, independent risk factor in more than 100 major medical conditions, including heart disease, strokes, and Alzheimer's disease. The authors discuss factors that contribute to high homocysteine, tell how to detect it if it's too high, and explain how to dramatically lower it.