Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

Rural Health: A Framework for Understanding the Issues and Their Impact on Rural Populations examines the factors that affect health care access and health status of individuals who live in rural areas. The text employs a unique structure called the Rural Health Framework, a methodology created by the authors during their years of teaching rural health at the undergraduate and graduate level. This framework challenges students to collect data and facts about rural areas to help them better understand rural health issues. The book emphasizes the complexity of rural health, the interprofessional nature of rural health care, and the importance of appropriate health care interventions for rural populations. The opening chapter provides readers with an overview of rural health terms and concepts. Additional chapters explore how geographic, economic, sociocultural, demographic, and support factors can impact heath status, access, and outcomes. The final chapter features an array of rural health case assessments to help students connect theory to real-world practice. Offering students an innovative and essential approach, Rural Health is an exemplary resource for courses in nursing, public health, medicine, social work, nutrition, and allied health.

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution.

Anthrax is only one of many biological threats. We read and hear about the others in the news: mad cow disease, shark attacks, killer bees, the West Nile virus, polluted wells-countless stories of biological hazards in the U.S. and around the world. This compact reference handbook covers everything from disease-causing viruses and bacteria, to harmful insects, poisonous plants, dangerous animals, and other types of living threats to human life. Readers will learn the nature of these hazards, the associated risks, and where to find information for further study and research. Topics include: Human Pathogens in Water Human Pathogens in Food Human Pathogens in Air Human Pathogens Transmitted by Contact Crop and Livestock Pathogens and Pests Toxins and Allergens Predators and Other Biological Hazards Hazard and Controversy. In each category, the author presents the current scientific knowledge on causes, preventive measures, costs, outlook, and other topics of interest. Historical contexts are also provided. Every chapter ends with an anecdote illustrating its major themes. Primary source documents, statistical information, and a glossary are added features that make this resource the ideal starting point for anyone interested in biological hazards.

Western medicine, including psychiatry and psychology, has had a virtual monopoly of the health industry. This has led to economic incentives that literally keep people sick. Anthropologists, because of their holistic and comparative base, are in a unique position to apply their knowledge within clinical settings. Written for anthropologists, but useful to all clinicians, Rush's book offers a new model for understanding health and illness, provides a review of techniques found in many cultures for reducing individual and system stress, and offers processes for recovering health and individual and social balance. Rush establishes a model outlining the development of emotional problems and then offers the clinicial tools and techniques for helping individuals, families, and groups reduce stress and retranslate traumatic or distressing events. The reader will discover a very different view of emotional and physical stress; the approach taken is informational and anthropological in nature. From this approach arise numerous techniques designed to help clients achieve stress reduction and enhanced healing.

This book describes the events, activities and negotiations leading up to the 2016 UN General Assembly Special Session on international drug policy. A range of respected authors from International institutions, academia and civil society organisations detail the background to the negotiations and the outcome; and possible future scenarios for continued reform and change at the High Level Review in 2019. The chapters include consideration of the positions taken by blocs and nation-states at all points on the prohibition - reform continuum. Topics covered include discussions on the importance of human rights, access to essential medicines and the role played by cannabis in revealing the contradictions and divisions in both national and international contexts. The break-down of the previous international consensus on 'the world drug problem' is clearly described and analysed, as is the slow progress being made to the adoption of a human rights and health-based approach to currently illegal drugs. Consideration is also given to the nations and arguments which continue to defend prohibition and its repressive impacts on national populations, and the prioritising of geo-politics over population health this represents in practice. There are lessons and examples here for international politics and national policy reform.

In the very first text of its kind, iWomen at Warr brings together all available information and experience on women's physical and mental health in one resource to enlighten the practitioners caring for them. The U.S Department of Defense is approximately 15% women, with over 300,000 women having deployed since September 11th, 2001. This book reviews the epidemiology, changes in policy and demographics of women in the services, the factors affecting their health and health care while serving in austere environments, issues related to reproductive and urogenital health and how health care providers can help prepare and prevent illness. The book also looks at mental health issues to include PTSD and other psychological effects of war, intimate partner violence, sexual assault and suicide, as well as the veteran experience. The book brings together researchers, clinicians, and service member experience and presents the information in a practical, actionable format. It also highlights areas where data is lacking and more study is demanded.

Dworkin and Wachs analyze 10 years of health and fitness magazines to uncover how bodies are made in popular culture Are you ripped? Do you need to work on your abs? Do you know your ideal body weight? Your body fat index? Increasingly, Americans are being sold on a fitness ideal-not just thin but toned, not just muscular but cut-that is harder and harder to reach. In Body Panic, Shari L. Dworkin and Faye Linda Wachs ask why. How did these particular body types come to be "fit"? And how is it that having an unfit, or "bad," body gets conflated with being an unfit, or "bad," citizen? Dworkin and Wachs head to the newsstand for this study, examining ten years worth of men's and women's health and fitness magazines to determine the ways in which bodies are "made" in today's culture. They dissect the images, the workouts, and the ideology being sold, as well as the contemporary links among health, morality, citizenship, and identity that can be read on these pages. While women and body image are often studied together, Body Panic considers both women's and men's bodies side-by-side and over time in order to offer a more in-depth understanding of this pervasive cultural trend.

At a moment when reproduction is increasingly politicized, this volume explores the breadth of contemporary research on reproduction from the perspective of medical sociology, illuminating the lived experience of reproduction and offering insights to inform sociology and health policy. Reproduction, Health, and Medicine elucidates the tensions and contradictions between the normal physiologic processes of pregnancy and birth and the sociocultural beliefs, values, and arrangements that shape how we experience these biological phenomena. Investigating a range of reproductive events and experiences, including pregnancy, birth, abortion and fertility planning, the volume advances our understanding of how lay people and professionals make cultural meaning out of these processes in diverse settings. The chapters highlight how studies of reproduction, health, and medicine interface with core sociological concepts such as stratification, inequality, intersectionality, family and kinship, risk, and social control, and how experiences of reproduction are shaped by gender, race, class, sexuality and citizenship, as well as culture, health care systems, and health politics.

The book deals with current issues, pertinent every healthcare relationship. Changes in medicine as well as some constant aspects over time arise within a cultural ground and generate new questions and issues that are not only purely medical, but also bioethical, social, political, economic and psychological of course. On the one hand, changes in medicine generate new questions for society, on the other hand, the society poses new questions to the medicine, new challenges, and in some cases they can conflict with consolidated models and practices. Never the progress of Western medicine and its therapeutic practices have been as significant as in the last decades but the increase of specific competence and effectiveness of medical treatments are not linearly translated into an increase of consensus, dialogue and alliance between medicine and society. How does psychology take on a position of interlocutor towards medicine and its transformations? How does Cultural Psychology, Health Psychology, Clinical Psychology confront themselves with the processes of meaning making generated by medicine? The interest of the book is aimed to grasp the construction of processes of cultural, relational and subjective meaning in the dialogical encounter between medicine and society, between doctor and patient. The book intends to focus in particular on two specific plans: on the one hand, to present a reflection and analysis on contemporary medicine and its on?going transformations of the healthcare relationship; on the other hand, to presentand discuss experiences of intervention and possible models of intervention addressed to healthcare and doctor?patient relationships during its crucial steps (consultation, formulation and communication of diagnosis, therapy, conclusion). The book's purposes are aimed to discuss crucial and current issues on the borders between medicine and psychology: consensus and sharing, decision?making and autonomy, subjectivity and narration, emotions and affectivity, medical semeiotics and cultural semiotics, training of physicians, and epistemological, theoretical and methodological issues.