Microsurgery for Fertility Specialists is an invaluable resource for physicians who specialize in the surgical treatment of male and female infertility. This practical text explains the basics of microsurgery and provides detailed operative descriptions of surgical procedures such as vasectomy reversal, sperm retrieval, tubal reanastomosis, and penile surgery. An exceptional cadre of reproductive specialists shares valuable knowledge of the current state of microsurgery, its role in infertility procedures, and the latest advances in the field --including some non-infertility microsurgical techniques. The book is an essential educational guide for those with a more advanced knowledge of microsurgical practice as it includes chapters that will help them mentor residents and fellows, and inspire future generations of reproductive surgeons.

In this second volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques, and controversial issues in reproductive medicine. This volume includes discussion of cutting-edge topics such as epigenetics, proteomics, and the role of the environment in fertility, as well as insightful evidence-based discussion of common clinical procedures. It is the cumulative effort of a preeminent panel of experts presenting each chapter in a clear and well-balanced manner. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all those working to help couples resolve their infertility.

In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.

New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

In order for new reproductive technologies to improve the health and well-being of women, they must be acceptable to and used by women. We need, therefore, to not only know about the technology itself; we also need to know about the individuals who intend to use the technology and factors that influence use. Accordingly, this issue focuses on the multiple determinants that influence acceptability of reproductive technologies and the policy, political and legal implications associated with their use. Topics include personal and contextual barriers to use, limited access for poor women and women of color, and the social controversy surrounding this area.

In spite of the fact that almost eighty percent of all IVF cycles are unsuccessful, the dominant representations of the technology are of its success. Based on extensive interviews with women and couples who have undergone IVF unsuccessfully and who have since stopped treatment, and taking an overtly feminist approach, the book explores the ways in which IVF failure is experienced and accounted for. The book argues that IVF failure and the end of treatment have to be carefully managed over time in order to construct the self as 'normal' in the profoundly gendered context of reproductive normativity. Treatment failure is identified in the book not only as a central, but largely excluded, aspect of the experience of IVF, but also of a proliferating range of new, more controversial reproductive and genetic technologies.

The increasing understanding of individual differences in response to in-vitro fertilization (IVF) treatment, resulting from genetic and ethnical differences, has increased the potential for individualized treatment for patients, resulting in improved pregnancy and live-birth outcomes. This illustrated book summarizes, and provides updates on, the most recent developments in individualized infertility treatment and embryo selection techniques. Individualization is not only confined to the different steps in the ovarian stimulation process and the luteal phase support, but also to embryo selection techniques, which include, among others, the analysis of embryo development pattern and genetic testing. Chapters cover a multitude of topics, ranging from oocyte maturation and immunological testing to fertilization technique in the IVF laboratory and preparation for optimal endometrial receptivity in cryo cycles. Essential reading for IVF specialists and embryologists in IVF Clinics and also an important text for medical consultants specializing in reproductive medicine, gynecology and embryology.

Among the vast literature on contemporary reproductive technologies, Prosthetic Bodies stands out in its effective combination of insights, methods, and theories from the history of medicine, constructivist science and technology studies, and feminist theory. The double focus on IVF and related techniques, and fetal treatment and surgery, enables the identification of debatable tendencies within today's reproductive medicine: the translation of ever more medical problems basically unrelated to women's own reproductive health - and, in the case of fetal diagnosis and treatment, sometimes formerly even unrelated to reproduction as such - into medical indications for invasive, often highly experimental interventions in women's bodies. The analyses show how, through the operations and workings of reproductive technologies themselves, as well as a variety of discursive mechanisms within scientific language, today's recasting of men's fertility problems and children's congenital anomalies as women's reproductive problems comes to appear inevitable. The book challenges the ability of traditional forms of medical ethics and law to adequately identify this incremental process. The careful analyses and arguments in Prosthetic Bodies will be relevant to students of science and technology, gender studies, philosophy, medical ethics, and law, and others interested in the cultural, ethical, and political ramifications of contemporary reproductive technologies.

Don P. Wolf and Mary Zelinski-Wooten provide a comprehensive review of the procedures and techniques used in assisted reproduction, as well as in nuclear transfer for both the treatment of human infertility and the propagation of animals. Combining the details of clinical application with the physiological facts of reproduction, the authors treat subjects such as the in vitro maturation of oocytes, embryo culture, intracytoplasmic sperm injection, and the process of nuclear transfer. Cutting-edge and wide-ranging, Assisted Fertilization and Nuclear Transfer in Mammals offers clinical ARTs practitioners, research scientists, those responsible for animal care, and students not only an informative historical perspective on the development of ARTs, but also updates on several of the more dynamic clinical areas, and a highly practical understanding of their applications.

This extensively updated new edition provides an indispensable account of modern in-vitro fertilization practice, building upon the popularity of previous editions. The authors initially give a comprehensive review of the biology of human gametes and embryos, before outlining basic to advanced IVF techniques. New developments in practical techniques and understanding are discussed, including in-vitro maturation, vitrification, preservation of fertility for cancer patients, stem cell technology, preimplantation genetic testing, and the role of epigenetics and imprinting. The revised introduction also incorporates a 'refresher' study review of fundamental principles of cell and molecular biology, now updated with current knowledge of meiosis in human oocytes, embryo metabolism and basic principles of genome editing. With high-quality illustrations and extensive, up-to-date reading lists, it is a must-have textbook for trainee and practising embryologists, as well as clinicians who are interested in the scientific principles that underpin successful IVF.

Hope and strategies for couples dealing with male infertility If you or your partner is suffering from male infertility, you’re not alone. Millions of couples are struggling with this problem. About 40% of these couples have exclusively male infertility problems, while another 20% have both male and female infertility problems. Now, two leading experts, a urologist specializing in male infertility and a psychologist, team up to write the most complete guide available on male infertility. From the latest, state-of-the-art treatments to advice on how to handle the emotional aspects of male infertility, you’ll find out where to get the help you need. Overcoming Male Infertility also covers the psychological issues that are unique to men, and gives advice to women on helping their man through the trauma of infertility treatment—including how to get him to see a doctor in the first place.

Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, "Drosophila" and mice provide a global overview of the field.

Embryoimplantationisaremarkableandcomplexprocess. Approachesde- velopedfromthefieldsofcellanddevelopmentalbiology,immunology, andmolecularbiologyhavegreatlyenhancedourabilitytostudythe sharedaswellasuniquefeaturesofembryo-uterineinteractions. Impres- siveandcriticalgroundworkhasbeenlaidbyalargeanddedicatedarray ofendocrinologists,reproductivebiologists,andanatomists. Thesestudies havesetthestagetoutilizesensitiveandsophisticatedtechniquestode- tectandmodulateproteinandgeneexpression. Justasthesymbiosisofmother andfetusiscriticalforthemaintenanceofpregnancy,soisthesynergyamong investigatorsfrommanydisciplines,bothinbasicandclinicalarenas,keyto unravelingthemysteriesofimplantationandplacentation. Alargegroupof contributorsinthisfieldhadtheopportunitytomeetanddiscussthestateof thisartwiththesupportofSeronoSymposiaUSA,Inc. Whileitisneverpos- sibletobringtogethereveryonewhohasplayedanimportantrole,itwas, nonetheless,bothexcitingandgratifyingtohavesomanycolleaguestogether forthisevent. Inthechaptersthatfollow,thehighlightsofthismeetingarepresented assummarizedbytheindividualpresentersofsevendifferentsessions. The topichasbeenconsideredfromthebroadsocialandethicalimplications ofmoderninvitrofertilizationandassistedreproductivetechnologiesto detailedmolecularcontrolsovereventsthatoccurduringembryonicdevel- opment,uterinepreparationforimplantation,andplacentalorganogenesis. Thesechaptersdemonstratethesignificantandrapidprogressbeingmade inthisfieldofbiologyandmedicine. Atthesametime,theyshowthat muchmoreneedstobedonetounderstandandfullyappreciatethispro- cess. Lessonslearnedfromthiseffortcanbeexpectedtocontinuetopro- videinsightsintoother,relatedfields. Ofthemanycontributorstoour understandingoftheprocessofimplantation,nonehavehadalargerim- pactthanourcolleague,AllenEnders. Dr. Endershasplayedaparamount roleindevelopingthebasicunderstandingofthecellbiologicalprocesses vii VIII Preface underlyingimplantationandplacentationinmanyspecies,includinghu- mans. Hecontinuestocontributeandguidethoughtintheseareas. The participantsofthissymposiumrecognizedDr. Enders'impressivecontribu- tionsbyholdingthiseventinhishonor. DANIELD. CARSON * Contents Preface vii Contributors xiii PartI. Development and Future ofHuman In Vitro Fertilization and Embryo Implantation I. ImplantationintheHumanasViewedbyCanonLaw, CivilLaw,andNaturalReason 3 HOWARDW. JONES, JR. , RICHARDA. MCCORMICK, AND SUSAN L. CROCKIN 2. TheImpactofMaternalAgeandOvarianAge onImplantationEfficiency...12 STEVEN SPANDORFER AND ZEV ROSENWAKS Part II. CellularAspects ofImplantation 3. VascularInvasionDuringImplantationandPlacentation 23 ALLEN C. ENDERS AND THOMASN. BLANKENSHIP 4. OxygenRegulatesHumanCytotrophoblastProliferation, Differentiation,andInvasion:Implicationsfor EndovascularInvasioninNormalPregnancy andPreeclampsia 39 OLGA GENBACEV,YAN ZHOU, MICHAEL T. McMASTER, JOHNW. LUDLOW, CAROLINEH. DAMSKY, AND SUSAN1. FISHER 5. Embryo-MaternalInteractionsafterDiapause inaMarsupial 54 MARILYNB. RENFREE AND GEOFFREY SHAW IX x Contents 6. CellularInteractionsandtheCysteineProteinases intheProcessofMouseImplantation 67 BRUCE BABIARZ, SUZANNE AFONSO, ANDLINDA ROMAGNANO Part III. HormonalRegulation 7. NovelSteroid-RegulatedMarkersofImplantation 83 INDRANIC. BAGCHI 8. MolecularSignalinginImplantation 92 SANJOYK. DAS, BIBHASHC. PARIA, AND SUDHANSU K. DEY 9. IdentificationofProgesterone-RegulatedGenes intheUterus 107 CINDEER. FUNK, BERTW. O'MALLEY, AND FRANCESCO1. DEMAYO PartIV. MolecularMarkersofReceptivity 10. MucinsProvideaBarriertoEmbryoImplantation 123 MARYM. DESOUZA, GULNARA. SURVEYOR, XINHUI ZHOU, JoANNE JULIAN, ANDDANIELD. CARSON II. PotentialInvolvementofTrophinin,Bystin, andTastininEmbryoImplantation 132 MICHIKON. FUKUDA, DAITA NADANO,NAO SUZUKJ, AND JUN NAKAYAMA 12. OsteopontininHumanEndometrium: ARoleinEndometrialReceptivityand EmbryoImplantation? 141 CHRISTOS COUTIFARJS,AKINYINKA OMIGBODUN, PIOTR ZIOLKIEWICZ, AND JOHN HOYER PartV. TrophoblastFactors 13. TheRabbitasaModelforImplantation: InVivoandInVitroStudies 151 LORENH. HOFFMAN,D. RACHEL BREINAN, AND GARETHL. BLAEUER 14. RegulationofTrophoblastEndocrineFunction: ThePlacentaDoesItsOwnThingTranscriptionally...161 JEROMEF. STRAUSSIII ANDLEE-CHUANKAo Contents XI 15. TranscriptionFactorsRegulatingtheDifferentiation oftheTrophoblastCellLineage 167 IANC. SCOTTANDJAMESC.

Erectile dysfunction is a complex syndrome associated and determined by several separate vascular and nonvascular factors. In recent years, the evolution of noninvasive vascular technology used to investigate macro- and microcirculation in vascular disorders has produced a large amount of information and increased our knowledge of vascular pathophysiology. Andrea Ledda and his clinical research group, well known to their international colleagues, describe new developments in andrology and stress the importance of vascular disorders in erectile dysfunction. This volume will be very useful to andrologists, vascular surgeons, and angiologists, and to all specialists interested in the diagnostic evaluation of erectile disorders and varicocele.

Help your patients through the maze of infertility treatments

Infertility is suffered by around 1 in 7 couples and can be a source of confusion for both partners, providing high stress on relationships. 25% of cases are explained through male infertility, 50% through female infertility, whilst 25% are generally unexplained. The possible causes and solutions are many and complex.

Infertility, one of the first in the new Gynecology in Practice series, assists gynecologists and family practitioners to better care for their patients who have trouble conceiving. The authors provide a strong focus on effective diagnosis and management. Following a review of the factors that affect fertility, Infertility takes a practical approach to: Evaluation of fertilityManagement and treatmentComplicationsPre-implantation screeningFertility preservation

Gynecology in Practice

The Gynecology in Practice series provides clinical 'in the office' or 'at the bedside' guides to effective patient care for gynecologists. The tone is practical, not academic, with authors offering guidance on what might be done and what should be avoided. The books are informed by evidence-based practice and feature: Algorithms and guidelines where they are appropriate''Tips and Tricks' boxes - hints on improving outcomes'Caution' warning boxes - hints on avoiding complications'Science Revisited' - quick reminder of the basic science principlesSummaries of key evidence and suggestions for further reading

This comprehensive text makes an important contribution to the study of surrogacy, developing a novel theoretical framework through which to understand the broader social contexts as well as individual decisions at play within surrogacy arrangements. Drawing on empirical research conducted by the authors and supplemented by secondary analyses of media, legislative and public accounts of surrogacy, the book engages with the key stakeholders involved in the practice of surrogacy. Specifically, it canvases the standpoints of women who act as surrogates, intending parents who commission surrogacy arrangements, children born through surrogacy, clinics that facilitate the arrangements, and politicians and journalists who engage with the topic. Through a focus on capitalism as a means of orientating ourselves to the topic of surrogacy, the book highlights the vulnerabilities that potentially arise in the context of surrogacy, as well as the claims to agency invoked by some parties in order to mitigate vulnerability. In so doing, the book demonstrates that the psychology of surrogacy must be broadly understood as an orientation to particular ways of thinking about children, reproduction and economies of labour.

The last step in the IVF treatment cycle, embryo transfer, is also the process with the highest failure rate. No matter how good the laboratory technique is, a successful pregnancy will not be achieved without meticulous preparation of the uterus to accept the embryo. This book reviews the scientific evidence on endometrial receptivity, including histological, hormonal, biochemical, and immunological factors. Practical and concise, it supports gynecologists and embryologists to make evidence-based decisions that can influence the success rates of implantation and live births. Part of a series of books offering treatments and strategies for fertility and conception to optimize IVF outcomes, this volume is for all clinicians and embryologists working in reproductive medicine.

Having Your Baby Through Egg Donation is a helpful, authoritative guide to negotiating the complex and emotive issues that arise for those considering whether or not to pursue egg donation. It presents information clearly and with compassion, exploring the practical, financial, logistical, social and ethical questions that commonly arise. This fully updated second edition also includes recent developments in the field, including travelling for egg donation and the emerging field of epigenetics. This book will be valued by all those considering or undergoing donor conception, as well as the range of professionals who support them, including infertility counsellors, psychologists, therapists and social workers.

This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.

Infertility has a major impact on the lives of people. This title is written for the many couples who, following diagnosis of infertility, desperately want an account of the problems of infertility and the help and services available. It is also aimed at the many professionals who are looking for an overall view.

An account from the frontline of fertility treatment, giving a unique insight into not only the medical and scientific advances involved but the human cost and rewards behind this life-changing technology. Simon Fishel worked with Robert Edwards during his pioneering early IVF research and was part of the team in the world's first IVF clinic, with all the trials and tribulations that involved at the time, including a writ for murder! As the science developed over the decades so did his career, as he sought to do more for patients and taught the new technologies to doctors all over the world. He came up against regulatory and establishment barriers, including fighting a 3-year legal case in the High Court of Justice and a death threat from a doctor if he refused to work with him. The clinic he founded has grown into the largest IVF group in the UK, developing exciting new procedures, and he has helped establish clinics throughout the world, even being invited to introduce IVF to China.

The second edition of this popular text systematically addresses all aspects of treatment of infertility using Chinese medicine. Clinically focused and with a new easy-to-navigate design, the book begins by covering all the essential fundamentals you will need to understand and treat infertility, before going on to look at what Chinese medicine offers in the way of treatment for functional infertility in men and women, gynecological disorders which contribute to infertility and relevant lifestyle factors. Jane Lyttleton importantly devotes a large part of the book to discussing ways in which Chinese medicine and Western medicine might work together to overcome infertility, and details the increased experience over the past decade in working with IVF patients and their specialists. Leaps forward have also been made in the understanding of conditions such as Polycystic ovarian syndrome and immune infertility.  New Features ·      Greatly expanded section on the place of Chinese medicine and IVF in treatment of infertility ·      New information on Polycystic ovarian disease and immune infertility and how Chinese medicine approaches their treatment ·      Updated and balanced advice on pre-conception care ·      Clinically focused, with easy-to-navigate design

' Charlotte Grand gives sensible practical advice' Dr Clare Bailey 'Full of insightful information, valuable health hacks and delicious recipes' Dr Mark Surrey The Fertility Kitchen is the go-to nutrition and lifestyle cookbook for anyone who wants to become pregnant - whether they are just starting to think about having a baby, have been trying for a while, are navigating infertility or exploring assisted conception. In today's fast-paced society, we are so used to getting what we want, when we want it. For women suffering with infertility it can be the first time they find themselves in a situation they have little control over: they can feel powerless. The Fertility Kitchen will help to reclaim some of that lost power. Part one of The Fertility Kitchen is based around the three 'pillars' of 'Fertility', 'Food', and 'Life', that sit at the heart of everything Charlotte is passionate about, giving a framework for an achievable life-style change. Charlotte shares her expertly tailored, nutrient-rich fertility nutrition and lifestyle plan, covering stress, movement, sleep, and social connection. Part two will help readers put this plan into practice with over 60 original flavour-packed yet simple recipes that embrace everything that's good for fertility. Charlotte explains the food philosophy that she teaches her clients, the foundations of good nutrition and its importance for optimal fertility. She addresses the key areas of health that can affect fertility, enabling readers to personalise their diet to suit their unique needs, as well as outlining the impact lifestyle can have on fertility, giving readers the strategies to achieve balance across all aspects of their life.

ONE OF PEOPLE MAGAZINE'S BEST SUMMER READS 2022 5* 'A jaw-dropping memoir' - THE TELEGRAPH 'One of the maddest memoirs you'll read this year... a beautiful, warm, funny book.' -The Times 'A wholly absorbing page-turner that everyone will want to read. You should probably buy two.' -Kirkus Starred Review 'A riveting debut.' -People Magazine 'By turns hilarious, wrenching, and achingly tender.' -Susan Orlean, New York Times bestselling author 'A remarkable and wise book, two memoirs braided together with such tendresse that readers will come to believe the ironic title in earnest' -LA TIMES 'Riveting and hilariously funny' - The Times For most of her life, Chrysta Bilton was one member of a small, if dysfunctional, family of four. There was her sister, Kaitlyn, her hedonistic, glamorous, gay mum Debra, and Jeffrey, who Debra hand-picked, in an LA hairdressers, to be the father of her children. During Chrysta's unstable childhood, Debra struggled to keep the family afloat and Jeffrey wandered in and out of their lives. Then, in her twenties, Chrysta discovered that her father had secretly donated his sperm over 500 times - and that she had at least 35 other siblings. A Normal Family is a captivating coming-of-age memoir about Chrysta's reckoning with the secrets both parents had carefully kept from her. Heartfelt, warm and funny, it's a story of embracing the family we have, in all the forms we find it.

This handbook is a guide to infertility and ultrasound for gynaecologists and infertility specialists. The second edition has been fully revised and includes many new topics, providing the latest information in the field. Divided into two sections, the first half of the book covers infertility. Beginning with discussion on assessment of an infertile couple, the following chapters examine different hormone treatments, sperm preparation, and ovulation induction, including in patients with polycystic ovary syndrome. The remaining chapters cover male infertility, recurrent pregnancy loss, and practical tips for infertility management. The second part of the book covers ultrasound. Beginning with discussion on transvaginal sonography and ultrasound in different uterine diseases, the following chapters cover ultrasound in infertility treatment, as well as in the different trimesters of pregnancy. Screening for foetal abnormalities is also discussed in depth. The comprehensive text is highly illustrated with more than 700 ultrasound images, diagrams and photographs. Key points Practical guide to infertility and ultrasound for specialists in gynaecology and infertility Fully revised, second edition featuring many new topics Highly illustrated with more than 700 ultrasound images and diagrams Previous edition (9789351528562) published in 2015

Infertility affects about 15% of couples in western societies. In addition to isolation, infertility challenges women's sense of identity, expectations of their life trajectory and their perceived value in society. This book presents current research on the genetic factors, treatment risk and benefits, and social and psychological consequences of infertility. Topics include the traditional Chinese medicine approach to fertility management; adverse outcomes of assisted reproduction techniques; the impact of follicular fluid components and embryo-endometrial cross-talk on the oocyte quality or embryo viability; iatrogenic damage incurred during fertility treatment upon gamete competence and embryonic viability; genetic factors of male infertility; animal models for studying female infertility; and treatment of endometriosis associated with infertility.