Novel Approaches into the Origins of Neurodevelopmental Disorders: The Fetal Physiology Foundation Over the past two decades, autism, a neurodevelopmental disorder that is defined by behavior and was once believed to be rare, became recognized in increasing numbers of children and recently received distinction as an "epidemic" [1]. While numbers of affected children have steadily increased, our knowledge is still ins- ficient to explain autism's diverse causes and broad range of presentations. Despite remarkable progress in research, available medical diagnostic testing applies only to a small minority of affected children. Thus, scientifically based explanations with which physicians can diagnose and treat the majority of children with autism and advise their parents are quite limited. Our society and scientific community were unprepared for the rise in autism, which explains our present inability to understand most of its causes. Researchers in neurodevelopmental disorders have long been aware of other disorders that, despite extensive efforts, have not yielded clear genetic or environmental origins, and autism has become symbolic of the need for new approaches to research into these complex conditions. Although autism has captured our attention in recent years, the prevalence of other neurodevelopmental disorders such as attention de- cit hyperactivity disorder (ADHD) and bipolar disorder, among others, also has been increasing [2-4].

Obstetrical emergencies can be among the most stressful events an emergency physician will face in their entire career. The purpose of this book is to provide an evidence-based, practical approach to the wide spectrum of obstetric complications an emergency physician must be prepared to manage throughout all trimesters pregnancy as well as postpartum, including complications of assisted reproductive technology, bleeding, precipitous delivery and preterm labor. Clinical pearls and pitfalls are highlighted throughout. The approach to the pregnant patient with trauma, non-pregnancy-related abdominal pain, or in cardiac arrest is discussed. Updates in the classification and management of the hypertensive disorders of pregnancy are presented. Recent controversies surrounding the use of anti-emetics for first trimester nausea and vomiting and the use of a beta-hCG discriminatory zone for the evaluation of pregnancy of unknown location are also addressed. Obstetrical support services vary widely between different facilities, and Emergency Department Management of Obstetric Complications is written for emergency clinicians in all practice settings. This book provides useful information for daily practice as well as preparation for rarely encountered and potentially life-threatening events.

This second edition of a groundbreaking book is substantially revised to deliver the foundation for an evidence-based model for best practices in midwifery a model critical to raising the United States current standing as the bottom-ranking country for maternity mortality among developed nations. With a focus on updated scientific evidence as the framework for midwifery practice, the book includes 21 completely new chapters that address both continuing and new areas of practice, the impact of institutional and national policies, and the effects of diversity and globalization. Incorporating the midwifery model of care, the book provides strategies for change and guidance for implementing evidence-based best practices. The book examines midwifery efforts to improve the health of women and children in the U.S., for example, Strong Start, US MERA, Centering Pregnancy, a focus on physiologic birth, and successful global endeavors. It encompasses a diverse nationwide authorship that includes leaders in midwifery, academicians, midwives representing diversity, hospital- and community-based practitioners, and policymakers. This coalition of authors from diverse backgrounds facilitates an engaging and robust discussion around best practices. Chapters open with a contemporary review of the literature, a comparison of current (often scientifically unsubstantiated and ineffective) practices, evidence-based recommendations, and best practices for midwifery. Key Features: Focuses on scientific evidence as the framework for midwifery practice Addresses continuing and new, controversial areas of practice with strategies and guidelines for change Includes 20 out of 27 completely new chapters Authored by a diverse group of 44 prominent midwifery leaders Examines practices that are in conflict with scientific evidence

Congenital malformations are worldwide occurrences, they know no national borders, do not distinguish between races, ethnicities, rich or poor. These severe physical abnormalities, present at birth, happen more often than is usually realized, once in every 33 births. They strike every part of the body, limbs, head, heart, and all others.

The most frequent of them all are the many types of malformations of the cardiovascular system, the heart and its blood vessels, which happen in about once in every 250 births. Study of these conditions during the twentieth century took many forms, revolving about examination and analysis of their causes, genetic, nongenetic, and complex. To aid in unraveling the complexities of this causation, various influences on their frequency are considered, among them social conditions, maternal health, birthweight, newborn maturity. And of course the known and possible environmental bases of their occurrence are fully described.
The relation of infant death to cardiovascular malformation is noted; and puzzlement that the level of such deaths had not kept pace with the reduction of infant death itself and of that associated with other kinds of malformations during this period.

An introductory record of the history of perinatal mortality in the last three centuries gives foundation for the discussion of death in contemporary decades.

This contributed volume is the first-known collection of essays that brings together scholarly review, critiques, and primary and secondary data to assess how sociocultural factors influence health behavior in South Asian women. The essays are authored by working scholars or healthcare practitioners from Bangladesh, India, and Pakistan. In the chapters, the contributors acknowledge social, economic, and environmental factors to recommend improved interventions and health policy for women of the region. Studies on South Asian women's health have targeted clinical evidence, with less attention on social and environmental factors driving health recovery and health outcomes. The South Asian region, more than any other part of the world, is driven by traditional and cultural forces that are possibly the most significant factors determining a woman's health awareness and her rights to adopt healthy behavior or pursue health recovery. Women of the region share a common culture and political history, and there are benefits to understanding their problems collectively in order to design joint improvements in health policy for women. Salient, but neglected, socio-political areas that influence health behavior and health outcomes in women of the region are covered in the chapters including: Oral Narrations of Social Rejection Suffered by South Asian Women with Irreversible Health Conditions Women's Role in Decision-Making for Health Care in South Asia Poverty, Health Coverage, and Credit Opportunities for South Asian Women Refugee, Displaced, and Climate-Affected Women of South Asia and Their Health Challenges The Political Sociology of South Asian Women's Health The Sociology of South Asian Women's Health is a useful resource for students, researchers, and academicians, especially those interested in public health, gender, social policy, and occupational management, as well as healthcare practitioners, administrators, health and public policy-makers, government officers, and scholars of South Asian studies.

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

Dana S. Belu combines Heidegger's phenomenology of technology with feminist phenomenology in order to make sense of the increased technicization of women's reproductive bodies during conception, pregnancy, and birth.

Bioethics and the Fetus: Medical, Moral, and Legal Issues is the ninth volume in the Biomedical Ethics Reviews series of texts designed to review and update the literature on issues of central importance in bioethics today. All of the essays in this volume examine moral and/or legal problems involving human fetal life; summaries of these essays may be found in the text's Introduction. Bioethics is, by its nature, interdisciplinary in character. Recog- nizing this fact, the authors represented in the present volume have made every effort to minimize the use of technical jargon. At the same time, we believe the purpose of providing a review of the recent literature, as well as of advancing bioethical discussion, is well served by the pieces collected herein. We look forward to the next volume in our series, and very much hope the reader will also. James M. Humber Robert F. Almeder vii Contributors Andrea L. Bonnicksen * Department of Political Science, Northern lllinois University, DeKalb, lllinois David W. Drebushenko * Department of Philosophy, Central Michigan University, Mount Pleasant, Michigan Roger B. Dworkin * School of Law, Indiana University, Bloomington, Indiana Mary B. Mahowald * Pritzker School of Medicine, The University of Chicago, Chicago, lllinois Christine Overall * Department of Philosophy, Queens University, Kingston, Ontario, Canada WadeL. Robison* College of Liberal Arts, Rochester Institute of Technology, Rochester, New York Barbara Katz Rothman * Department of Sociology, Baruch College, CUNY, New York, New York Thomas A.

This contributed volume explores flexible, adaptable, and sustainable solutions to the shockingly high costs of birth across the globe. It presents innovative and collaborative maternity care practices and policies that are intersectional, human rights-based, transdisciplinary, science-driven, and community-based. Each chapter describes participatory and midwifery-oriented care that helps improve maternal and newborn outcomes within minoritized populations. The featured case studies respond to resource constraints and inequities of access by transforming relations between providers and families or by creating more egalitarian relations among diverse providers such as midwives, obstetricians, and nurses that minimize inefficient hierarchies within maternity care. The authors build on a growing awareness that quality and respectful midwifery care has lower costs and improved outcomes for child bearers, newborns, and providers. Topics include: Sustainable collaborations including transfers of care among midwives and obstetricians in India, The Netherlands, Germany, United Kingdom, and Denmark Midwifery-oriented, femifocal, indigenous, and inclusive models of care that counter obstetric violence and gender stereotypes in Mexico, Chile, Guatemala, Argentina, and India Doula care and midwifery care for women of color, previously incarcerated women, indigenous women, and other minoritized groups in the global north and south Practices and metrics for improving quality of newborn and maternal care as well as maternal and newborn outcomes in disruptive times and disaster settings Sustainable Birth in Disruptive Times is an essential and timely resource for providers, policy makers, students, and activists with interests in maternity care, midwifery, medical anthropology, maternal health, newborn health, obstetrics, childbirth, medicine, and global health in disruptive times.

This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.

This volume provides an overview of the research describing the effects of child maltreatment on mental health, cognitive and social-emotional development. It offers descriptions of selected empirically based treatments (EBTs) written by scholars associated with its development, training, or research on its effectiveness. Each contributor presents the theoretical foundation of the EBT and evidence of its efficacy, describes the treatment process and illustrates this process with a case study of its use with a maltreated child, and discusses possible limitations. Following the chapters describing the interventions, the editors address key issues of the dissemination and implementation of these EBTs. They describe the strategies the selected interventions have used to ensure treatment fidelity in training and dissemination from the perspective of implementation science's core components of implementation. The challenges of implementing EBTs, and the difficulty of fitting protocol to the reality of clinical practice in community mental health settings are also discussed. This volume offers a central source of information for students and practitioners who are seeking effective interventions to address problems associated with child maltreatment.

This second edition updates the reader on the most common intrauterine transmitted viral infection, CMV. The history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed in detail. Further a section specifically dedicated to prevention measures is included to the new edition. The chapter on virus-host interaction for defense and transmission is elaborately updated.

Congenital malformations are worldwide occurrences striking in every condition of society. These severe physical abnormalities which are present at birth and affecting every part of the body happen more often than usually realized, once in every 33 births. The most common, after heart defects, are those of the neural tube (the brain and spinal cord) which happen in as many as one in every 350 births. They have been noted as curiousities in man and beast throughout recorded history and received great attention in our time by various fields of study, for example, their faulty prenatal development by embryologists, familial patterns by geneticists, causation by environmentalists and variability by population scientists.

Attention turned much in recent years to the relation of these malformations to deficiency of a particular dietary ingredient, folic acid, a subject this book analyzes in depth. The greatest conundrum of all, which this latest matter like so much else hinges on, is the amazing fact of the tremendous, almost universal decrease in the frequency of these anomalies since early in the 20th century. The puzzle is 'What can this downward trend possibly mean?' and at bottom 'Whether it is part of a long-term cyclical pattern'. This fascinating biological phenomenon is explored in the book together with various other topics.

Quick, one-stop guide to neonatal resuscitation steps. Great take-along for all newborn care providers. Size: 4" x 3.5" (Two card set)

This book brings together an international collection of experts in reproductive ethics, law, disability studies, and medicine to explore the challenging future of reproduction and children. From the medical to the social and from the financial to the legal, the authors explore the expanding impact of reproductive genetics on our society. New advances in genetic technologies are revolutionizing the practice of reproductive medicine. We have expanded our ability to detect genetic changes in embryos and fetuses in ways that potentially allow to identify, treat, or prevent a growing range of diseases. The development of gene-editing technologies raises questions about the possibility of removing disease-causing variants from embryos before pregnancy implantation. The growing sophistication of prenatal genomic sequencing offers us glimpses into the whole genome of the developing fetus. And, the increasingly sophisticated science of 'gene matching' allows us greater and greater foreknowledge of how the genomes of two individuals will combine in a future child. This is an indispensable book on the newest developments in bioethics caused by the sciences. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book presents models describing HIV transmission rates at population level, discussing the main statistical methods and analytical interventions. It also assesses the practical applicability of the various modelling techniques, offering readers insights into what methods are available and, more importantly, when they should be used to address HIV transmission at global level. The book includes realistic simulation models fitted to clarify the rate of HIV mother-to-child transmission (HIV MTCT), and substantiates the conclusions that can be drawn as well as the appropriate time for making global-level clinical decisions concerning people living with HIV/AIDS (PLHIVs). Intended for students, academics and researchers, the book offers more than just an introduction to the topic - it also features in-depth, yet easy-to-understand, descriptions of a new mathematical/statistical HIV mother-to-child transmission model, making it a useful resource for clinicians, public health workers and policymakers involved in implementing HIV-prevention programmes at national /global level.

A collection of cutting-edge laboratory techniques for the study of trophoblast and placental biology. The techniques presented range from experimental animal models, to animal and human placental organ and cell culture systems, to morphological, biochemical, and molecular strategies for assessing trophoblast/placental growth, differentiation and function. Volume 1 provides readily reproducible protocols for studying embryo-uterine implantation, trophoblast cell development, and the organization and molecular characterization of the placenta. Highlights include strategies for the isolation and culture of trophoblast cells from primates, ruminants, and rodents, and precise guidance to the molecular and cellular analysis of the placental phenotype. A companion second volume concentrates on methods for investigating placental function.

Among women's health concerns, reproductive issues, both prenatal and postpartum, hold particular prominence. Yet despite the many programs dedicated to improving women's reproductive health, maternal and infant morbidity and mortality rates in minority communities remain unchanged-or have increased. Confronting this alarming statistic head-on, "Reducing Racial/Ethnic Disparities in Reproductive and Perinatal Outcomes" is the first book systematically examining public health interventions designed toward meeting this important and elusive goal. Its contributors offer the best thinking and practice on this complicated topic, clarifying the relationship between evidence-based medicine and evidence-based public health and its potential for increasing parity, considering interventions in the multiple contexts of women's lives, reviewing the evidence base for each program or initiative featured, and describing methodologies for evaluating interventions. The resulting volume advocates for an integrative lifespan approach, including topics related to: Family planning STI and HIV/AIDS screening and treatment Smoking cessation and reducing exposure to environmental smoke Preconceptional well-woman care Depression screening and treatment Labor/delivery approaches and intrapartum care Emerging prenatal care interventions, from centering pregnancy to doula support

For professionals and graduate students in psychiatry, psychology, sociology, women's health, and public health, "Reducing Racial/Ethnic Disparities in Reproductive and Perinatal Outcomes" reframes a set of ongoing issues and guides the reader toward state-of-the-art solutions.

Quick, one-stop guide to neonatal resuscitation steps. Printed on flexible plastic with self-adhesive mounting strips. Size: 22" x 34

Hypertension: from basic research to clinical practice" contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.

The HIV pandemic continues to levy a heavy burden on the human race world-wide. The estimated number of people who became newly infected with HIV in 2009 was 2.6 million; most of these individuals live in Sub-Saharan Africa, followed by India and Southeast Asia. An estimated 370,000 new cases of pediatric infections occurred globally in 2009 (or more than 1,000 new infections every day), practically all of them through mother-to-child transmission. Up to 40% of all new infant HIV infections occur during breastfeeding. While breastfeeding by HIV-infected mothers is not recommended in the U.S. and other resource-rich settings where safe replacement feeding is easily available, the situation is different in many resource-limited settings, where replacement feeding is not safe or available and carries a high risk of infections (diarrhea, pneumonia) and infant malnutrition. Mothers in such settings are faced with a difficult dilemma: to breastfeed their infants in order to provide their infants with its many benefits (nutritional, immunologic, cognitive), but to also risk transmitting HIV. These challenges have prompted an intensive search for new prophylactic and therapeutic strategies in order to prevent infants from acquiring HIV infection through breastfeeding. In this book, expert HIV researchers critically review every aspect of this highly evolving and topical subject. The opening chapters deal with the epidemiology, global magnitude and biologic mechanisms of HIV-1 transmission from mother to child through breastfeeding and include considerations of the virus (quantity, compartments, characteristics) and the host (genetic, immunity-innate, cellular, humoral). The effects of breastfeeding on the HIV-infected mother's health and nutritional status, and the social and cultural issues associated with the practice of breastfeeding are also discussed. The next few chapters provide cutting-edge reviews of the latest approaches to prevention of HIV transmission to the infant through breastfeeding, including antiretroviral strategies, nutritional and immune-based approaches, and treatment of expressed breast milk. The remaining chapters provide a fascinating review of the many iterations this subject has received, as reflected in the several different sets of guidelines for infant feeding by HIV-infected mothers issued by the World Health Organization, and a debate by leading scientists on whether HIV-infected mothers should breastfeed their infants-in resource-limited and in resource-rich settings. A comprehensive overview of the current state of implementing the new evidence for prevention of breastfeeding transmission of HIV all over the world is also presented. Essential reading for the many disciplines of scientists and clinicians working on HIV/AIDS and other retroviruses, pediatricians, obstetricians/gynecologists, as well as all health-care professionals interested in expanding their understanding on the subject.

Pregnancy is the main determinant of some liver diseases in humans: acute fatty liver of pregnancy, cholestasis of pregnancy, and acute liver failure in toxaemia of pregnancy. Pregnancy also modifies the natural history of other more common hepatobiliary diseases, such as cholesterol gallstones. Sex hormones (mainly oestrogens, progesterone and/or some of its metabolites) and prolactin are considered responsible for these pathological consequences and they also appear to be influential in the outcome of several other hepatobiliary disorders, in both sexes and all ages. Although these disorders and their hormonal interrelations have been clinically well characterized, their pathogenesis remains obscure from the biomolecular point of view. In recent years, novel approaches using new technologies have improved our understanding of hormone actions and metabolism, hormone receptors, metabolic pathways and their interrelations with closely related molecules, such as bile acids. This book, the proceedings of the 89th Falk Symposium, held in Santiago, Chile, 10-11 November, 1995, will help research scientists and clinicians to review basic and clinical aspects of these interactions, in order to stimulate biomedical research in a relevant and exciting area.

A panel of top experts in perinatal psychiatry reviews the many recent studies on the use of psychiatric medications in pregnancy and postpartum and assesses their impact on the diagnosis and treatment of pregnant/postpartum women. The authors focus on each of the major psychiatric illnesses, including depression, anxiety disorder, bipolar disorder, schizophrenia, substance abuse, eating disorders, and mental illness, as well as on the potential impact of these illnesses on infants and children. Interpreting conflicting and inconclusive clinical findings, they spell out the lesser-known risks of prenatal medication exposure and illuminate a variety of issues that must be taken into account in choosing such treatments as medications, psychotherapy, parental education, and social skills training.

This is the only book to present the evidence-based policies and procedures that medical and non-medical staff can use to develop Mother-Friendly Care in their facilities. The Mother-Friendly Childbirth Initiative (MFCI), developed by the Coalition for Improving Maternity Services (CIMS), is a wellness model designed to improve birth outcomes and substantially reduce costs. It is an evidence-based mother-, baby-, and family-friendly model that focuses on prevention and wellness as alternatives to high-cost screening, diagnosis, and treatment programs. The MFCI is the first and only consensus document on U.S. maternity care and is recognized as an important instrument for change in the U.S. and abroad.

The book is based on research and evidence developed by CIMS and includes 10 protocols, each with detailed policies and procedures and supporting information and resources that help implement the change to Mother-Friendly Care. Each protocol is authored and reviewed by recognized leaders in a variety of childbirth and maternity care arenas. The book traces the development of Mother-Friendly Care and describes its core tenets along with supporting statistical information. These tenets eschew practices not supported by scientific evidence. The manual includes implementation strategies for the evidence-based nursing care training programs of such organizations as Lamaze, ICEA, and AWHONN, and supports the WHO-Unicef "Ten Steps of the Baby-Friendly Hospital Initiative" to promote successful breastfeeding.

Key Features: Provides evidence-based policies and procedures for developing Mother-Friendly Care in maternity care facilities Presents specific guidelines that can be used as a standard to measure Mother-Friendliness and subsequently used for marketing purposes Designed to provide childbirth educators and doulas with guidelines for promoting Mother-Friendly Care to birthing women Assists nurses who want to promote more rapid change on their units toward Mother-Friendly Care Supports the WHO-UNICEF "Ten Steps of the Baby-Friendly Hospital Initiative" to promote successful breastfeeding

In this unique book emphasis is placed on tests necessary to evaluate fetal well-being and to detect those fetuses at risk of hypoxia and acidosis in utero. Written by pioneers in the neonatal field, this publication contains chapters on the pathophysiology , obstetric management, and collagen diseases of intrauterine growth retardation. Ultrasound in detection of growth retarded fetuses is explored, as well as magnetic resonance imaging and magnesium substitution for the prevention of intrauterine growth retardation. Containing never-before-published information, this volume is an excellent reference source for both investigators in the field and those entering it. Topics Include: Perinatal growth chart for international reference Ultrasound guided procedures in small for gestation fetuses Utero-placental and fetal circulation