There are many unanswered questions regarding the molecular nature of antibodies, components of complement, and other substances which participate in the immune response. The list of substances which need to be analyzed chemically is increasing. Plasma cell products, of course, have long been of great interest because the most prevalent ones are immunoglobulins. Other cell types, however, are the source of the broad spectrum of additional substances which classically fall into the sanctum of the molecular immunologist. It is these substances, and especially those more recently discovered, which are responsible for the broadening investigative interests of immunologists. In this volume we have provided you with descriptions of research being done with immunoglobulins and with complement. Additionally, we have in cluded two reports that deal with molecules which are among the more recent acquisitions of the molecular immunologist. The components of complement are known to react in a cascading manner which results in the lysis of cellular antigens. The first step in the classical pathway requires the activation of CI by the antibody-antigen aggregates. This volume of Contemporary Topics in Molecular Immunology begins with the report of Reid and Porter which describes their investigation of the mechanism of activation of C I. Their descriptions of C I q and of the reaction of C I with immunoglobulins are especially intriguing. It is clearly apparent from their report that activation of the components of complement is a complex phenome non.

To scientists engaged in research on the cellular mechanisms in the mammalian brain, concepts of "motivation" seem to be a logical neces sity, even if they are not fashionable. Immersed in the detailed, time consuming research required to deal with mammalian nerve cells, we usually pay scant attention to the more global brain -behavior questions that have arisen from decades of biological and psychological studies. We felt it was time to confront these issues-namely, how far has neuro biological investigation come in uncovering mechanisms by which moti vational signals influence behavior? At Rockefeller University, we have recently held a course on this subject. We restricted our treatment to those motivational systems most tractable to physiological approaches, and invited scientists skilled in both behavioral issues and physiological techniques to participate. This volume results from that course. The deans and administration at Rockefeller University provided much help in planning the course, and the staff of Springer-Verlag assisted in planning the book. Gabriele Zummer helped organize both the course and the processing of book chapters. They all deserve our thanks. December 1981 Donald W. Pfaff Professor of Neurobiology and Behavior Rockefeller University Contents Part One: Concepts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chapter 1 Donald W. Pfaff Motivational Concepts: Definitions and Distinctions . . . . . . . . . . 3 Motivation: A Brief Review of Concepts. . . . . . . . . . . . . . . . . . . . . . . . . . 5 Drive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Reinforcement, Reward . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Incentive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Arousal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Emotion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Motivation Is a Unitary Behavioral Concept with Multiple Neurophysiological Mechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Chapter 2 Alan N."

Talking dolphins . . . Underwater cities . . . Two-hundred-year life spans . . . Welcome to the present

People have always imagined what life would be like in the future. Most of the time they've been wrong. Often they were really, really wrong. Your Flying Car Awaits looks at the most outrageous predictions from twentieth-century scientists, novelists, and social commentators, detailing the technologies and philosophies that led some great (and not so great)minds to think the ridiculous was achievable. Includes phenomenally inaccurate predictions such as: Space tourism will be ubiquitous by the year 2000Nuclear explosives will be used for commercial demolitionEngineered and man-made oceans will cover the planetWeather will be as predictable and controllable as a train schedule

An eye-opening, fascinating, and endlessly entertaining collection of truly boneheaded scientific predictions from the past hundred years, Your Flying Car Awaits shines an illuminating light on the people of the previous century by examining the ridiculous theories they envisioned about this one.

With more than 50% of the world's population already living in towns and cities, migration from rural areas continuing at an alarming rate in developing countries and suburbanisation using more and more land in developed countries, the urban environment has become supremely important with regard to human health and wellbeing. For centuries, urbanisation has caused relatively low level soil conta- nation mainly by various wastes. However, from the time of the Industrial Revolution onwards, both the scale of urban development and the degree of soil contamination rapidly increased and involved an ever widening spectrum of c- taminants. With constraints on the supply of land for new urban development in many countries, it is becoming increasingly necessary to re-use previously dev- oped (brownfield) sites and to deal with their accompanying suites of contaminants. It is therefore essential to fully understand the diversity and properties of urban soils, to assess the possible risks from the contaminants they contain and devise ways of cleaning up sites and/or minimizing hazards. The author, Helmut Meuser, is Professor of Soil Protection and Soil Clean-up at the University of Applied Sciences, Osnabruck and is one of Europe's foremost experts on contamination from technogenic materials in urban soils. He has many years' experience of research in Berlin, Essen, Osnabruck, other regions of Germany, and several other countries.

Stephen Webb, author of WHERE IS EVERYBODY?, takes the interested amateur on a thrilling and enlightening tour of the amazing, even bizarre, new ideas of modern physics, including alternatives to the Big Bang, parallel universes, and an imaginary trip to the other side of the black hole.

Simone Weil: philosopher, political activist, mystic - and sister to André, one of the most influential mathematicians of the twentieth century. These two extraordinary siblings formed an obsession for Karen Olsson, who studied mathematics at Harvard, only to turn to writing as a vocation.

When Olsson got hold of the 1940 letters between the siblings, she found they shared a curiosity about the inception of creative thought - that flash of insight - that Olsson experienced as both a maths student, and later, novelist.

Following this thread of connections, The Weil Conjectures explores the lives of Simone and André, the lore and allure of mathematics, and its significance in Olsson's own life.

Few scientists have made lasting contributions to as many fields as Francis Galton. He was an important African explorer, travel writer, and geographer. He was the meteorologist who discovered the anticyclone, a pioneer in using fingerprints to identify individuals, the inventor of regression and correlation analysis in statistics, and the founder of the eugenics movement. Now, Nicholas Gillham paints an engaging portrait of this Victorian polymath.

The cow. Central to human existence since time began, cows have served as a source of food, a means of labor, an economic resource, an inspiration for art, and even as a religious icon--many cultures worshipped the cow as a god.

Beef is the captivating history of an animal whose relationship with humanity has shaped the world as we know it. Peppered with lively anecdotes and culinary tidbits, this engaging panoramic view of the cow's long and colorful history spans the globe--from ancient Mediterranean bullfighting rings to the rugged grazing grounds of eighteenth-century England, from the quiet farms of Japan's Kobe beef cows to crowded American stockyards and the remote villages in East Africa that are home to the Masai, to whom cattle mean everything. Leaving no stone unturned, Beef is not only a compelling story but a necessary call to arms, offering practical solutions for confronting the sad current condition of the wasteful and destructive beef and dairy industries.

You will never look at steak the same way again.

In Recognition of the Forgotten Generation D. L. MULCAHyl Pollen was long believed to serve primarily a single function, that of delivering male gametes to the egge A secondary and generally overlooked value of pollen is that it serves to block the transmission of many defective alleles and gene combinations into the next generation. This latter function comes about simply because pollen tubes carrying defective haploid genotypes frequently fail to complete growth through the entire length of the style. However, the beneficial consequences of this pollen selection are diluted by the fact that the same deleterious genotypes are often transmitted through the egg at strictly mendelian frequencies (Khush, 1973). Gene expression in the pollen might thus at least appear to be a phenomenon of trivial consequence. Indeed, Heslop-Harrison (1979) rightly termed the gametophytic portion of the angiosperm life cycle, the "forgotten generation." This neglect, however, came about despite subtle but constant indications that pollen is the site of intense gene activity and selection. For example, Mok and Peloquin (1975) demonstrated that relatively heterozygous diploid pollen shows heterotic characteristics whereas relatively homozygous diploid pOllen does not. This was proof positive that genes are expressed (that is, transcribed and translated) in the pollen. 1 Department of Botany, University of Massachusetts Amherst, MA 01003, USA viii However, the implications for pollen biology of even this recent and well known study were not widely recognized.

Katherine Teilmann Van Dusen and Sarnoff A. Mednick This introduction delineates what we consider to be three of the most important impediments to the advance of knowledge in the field of criminology. The most fundamental need is for more studies of the nature and progress of criminal and delinquent careers. The second need is for more prospective, longitudinal studies of the etiology of crime and delinquency. The third need concerns the lack of interdisciplinary research toward a more integrated understanding of delinquent and criminal behavior. Criminal and Delinquent Careers The birth cohort study by Wolfgang, Figlio and Sellin (1972) was heralded by many (Farrington, 1973; Erickson, 1973; Weis, 1974) as a landmark which allowed researchers to study the course of delinquency without the usual sampling biases that plagued other, cross-sectional research. For the first time, we could get a reasonable picture of when delinquency usually starts, what proportion of the population engages in delinquency, what types of delinquencies they engage in, what proportion continue, and so on. Cross sectional studies do not permit the investigation of careers because cross 1 PROSPECTIVE STUDIES OF CRIME AND DELINQUENCY 2 sectional sampling includes only portions of careers for many of the individuals sampled. This is just one of the many problems that restricted researchers' ability to study the nature of criminal careers.

More than 1200 diterpenes have been identified from approximately 550 Compo sitae taxa (Figure 1 [pp. 219-384], Tables 1-3 [pp. 7-218]). The annual output of such reports rose sharply during the past several years, a trend that was also reflected by other major lipophilic constituents of the Compositae: acetylenes (63, 465), sesquiterpene lactones (266, 458), and benzofurans and chromenes (429). Unlike these other natural products, no review of the diterpene chemistry of the Compositae has been published. Given the bulk of data currently on hand, a review of this topic is clearly overdue. Several major goals influenced the preparation of this review. The first was to provide a useful reference to guide terpenoid chemists to the literature of known compounds. The published reports for 1200 structures provide a sizable body of spectroscopic data applicable to the investigation of new compounds. The study of diterpenes has been hampered by the absence of an all-inclusive nomenclature and classification system for the various skeletal types. Conse quently, a second goal was to organize structural data into a classification scheme designed to group compounds by biogenetic homology, and to standardize such features as diterpene nomenclature and numbering. Pursuant to this goal, the published names (Table 1) and numbering systems (Table 2) for all compounds are included.

Keep your feet on the ground and experience the night sky to the fullest by exploring planets, satellites, and constellations with this all-inclusive reference guide to space. 100 Things to See in the Night Sky, Expanded Edition is full of information on the many amazing things you can see with a telescope, or just your naked eye! From shooting stars to constellations and planets to satellites, this book gives you a clear picture of what you can see on any given night. Learn about the celestial bodies that have captured people's imaginations for centuries, with specific facts alongside traditional myths and beautifully illustrated photographs and star charts that will help you know where to look for the best view. With this illuminating guide, you'll enjoy hours of stargazing, whether you're travelling, camping, sitting in your back garden, or simply flipping through the beautiful images in this book.

This book explains hyperspace and multidimensional geometries in an effort to help readers to manipulate, visualize, and think about the higher spatial dimensions that all serious physical theories since relativity have required. This book alternates sections explaining the science with a fictional story line that exemplifies, comments on, and helps to clarify the science. The book also features a number of appendices, including annotated guides to the literature and to relevant science fiction, further commentary on the mathematics of hyperspace, questions and puzzles, and source code for modeling hyperspace. The book has the goal to explain the science of hyperspace accurately, but it is light and playful in its approach.

Fibronectins comprise a class of high molecular weight glycoproteins present both in extracellular matrices and in soluble form in body fluids. Although they have been studied for about forty years, their real significance emerged only during the past decade. Intensive research has focused on their role in platelet function, cell migration, the cytoskeleton, reticuloendothelial function, and on alterations in fibronectin distribution during development and disease. Fibronectins have emerged as glycoproteins with a very interesting set of properties generally involving adhesion of cells to cells or to extracellular material. In more recent years, the complete sequences of several fibronectin molecules and their genes were determined, the relation between structure and function was understood and much has been learned about cell surface receptors for fibronectins and other adhesive ligands. Having been at the forefront of all these exciting developments, the author has synthesized the entire field and with all the latest information at hand for the first time given it a clear perspective.

Writing for the general reader, Daniel Nettle tackles the question of why madness exists. He shows that there is, as long suspected, a link between madness and creative genius. He thus argues that the traits that lie behind madness have evolved because they have psychological benefits as well as psychological costs.

Is the future of food looking bleak - or better than ever? At a time when every day brings news of drought and famine, Amanda Little investigates what it will take to feed a hotter, hungrier, more crowded world. She explores the past along with the present and discovers startling innovations: remote-control crops, vertical farms, robot weedkillers, lab-grown meat, 3D-printed meals, water networks run by supercomputers, cloud seeding and sensors that monitor the microclimate of individual plants. She meets the creative and controversial minds changing the face of modern food production, and tackles fears over genetic modification with hard facts. The Fate of Food is a fascinating look at the threats and opportunities that lie ahead as we struggle for food security. Faced with a perilous future, it gives us reason to hope.

This elegant book presents current evidence on the organization of the mammalian cerebral cortex. The focus on synapses and their function provides the basis for understanding how this critical part of the brain could work. Dr. White and his colleague Dr. Keller have collated an impressive mass of material. This makes the crucial information accessible and coherent. Dr. White pioneered an area of investigation that to most others, and occasionally to himself, seemed a bottomless pit of painstaking at tention to detail for the identification and enumeration of cortical syn apses. I do not recall that he or anyone else suspected, when he began to publish his now classic papers, that the work would be central to an accelerating convergence of information and ideas from neurobiology and computer science, especially artificial intelligence (AI) (Rumelhart and McClelland, 1986). The brain is the principal organ responsible for the adaptive capacities of animals. What has impressed students of biology, of medicine, and, to an extent, of philosophy is the correlation between the prominence of the cerebral cortex and the adaptive "complexity" of a particular spe cies. Most agree that the cortex is what sets Homo sapiens apart from other species quantitatively and qualitatively (Rakic, 1988). This is summarized in the first chapter."

The world you can feel and touch is built of atoms, the smallest identifiable chunks of matter. Yet the heart of each atom is itself a whole new world, a world populated by quarks: indivisible, vanishingly small, the ultimate building blocks of our universe. This inner world where quarks reign is subject to new and unfamiliar rules, the rules of the quantum world. Colossal particle accelerators enable physicists to bring this inner world into focus, and have helped them shape a theory respectful of quantum rules that explains how quarks feel one another's presence. The Quantum Quark is the story of that theory: quantum chromodynamics.

Darwin's Armada tells the stories of Charles Darwin, Thomas Huxley, Joseph Hooker and Alfred Wallace, four young amateur naturalists from Britain who voyaged to the southern hemisphere during the first half of the nineteenth century in search of adventure and scientific fame. It charts their thrilling voyages to the strange and beautiful lands of the southern hemisphere that reshaped the young mariners' scientific ideas and led them, on returning to Britain, to befriend fellow voyager Charles Darwin. All three crucially influenced the publication and reception of his Origin of Species in 1859, one of the formative texts of the modern world. For the first time the Darwinian revolution of ideas is seen as a genuinely collective enterprise and one that had its birth in a series of gripping and human travel adventures. Many of the most urgent ecological and social issues of our times are seen to be prefigured in this compelling story of intellectual discovery.

The doctrine of computer life is not congenial to many people. Often they have not thought in any depth about the idea, and it necessarily disturbs their psychological and intellectual frame of reference: it forces a reappraisal of what it is to be alive, what it is to be human, and whether there are profound, yet un expected, implications in the development of modern com puters. There is abundant evidence to suggest that we are wit nessing the emergence of a vast new family of life-forms on earth, organisms that are not based on the familiar metabolic chemistries yet whose manifest 'life credentials' are accumulating year by year. It is a mistake to regard biology as a closed science, with arbitrarily limited categories; and we should agree with Jacob (1974) who observed that 'Contrary to what is imagined, biology is not a unified science'. Biology is essentially concerned with living things, and we should be reluctant to assume that at anyone time our concept and understanding of life are complete and incapable of further refinement. And it seems clear that much of the continuing refinement of biological categories will be stimulated by advances in systems theory, and in particular by those advances that relate to the rapidly expanding world of computing and robotics. We should also remember what Pant in (1968) said in a different context: 'the biological sciences are unrestricted . . . and their investigator must be prepared to follow their problems into any other science whatsoever."

The authors, leading representatives of Russian space research and industry, show the results and future prospects of astronautics at the start of the third millennium. The focus is on the development of astronautics in Russia in the new historical and economic conditions. The text spotlights the basic trends in space related issues before moving on to describe the possibilities of the wide use of space technologies and its numerous applications such as navigation and communication, space manufacturing, and space biotechnology. The book contains a large amount of facts described in a way understandable without specialist knowledge. The text is accompanied by many photographs, charts and diagrams, mostly in color.

J. Robert Oppenheimer, a leading physicist in the Manhattan Project, recognized that scientific inquiry and discovery could no longer be separated from their effect on political decision-making, social responsibility, and human endeavor in general. He openly addressed issues of common concern and as a scientist accepted the responsibility brought about by nuclear physics.

This collection of essays and speeches, only a few of which have been previously published, presents an extraordinary thinker and scientist as well as a compassionate human being. No issue is too small or too large if it is in some way connected to the emergence of a weapon as terrible and powerful as the atom bomb. Oppenheimer discusses the shift in scientific awareness and its impact on education, the question of openness in a society forced to keep secrets, the conflict between individual concerns and public and political necessity, the future of science and its effects on future politics---in short, the common and uncommon sense we find in our modern day reality.

Uncommon Sense presents a responsible scientist and a concerned man who foresaw the problems the discovery of fission would create. And we should no neglect to read between the lines: The peak of Oppenheimer s career coincided with the McCarthy era, the repercussions of which strongly affected his personal and professional life. The themes of openness and freedom becomes, therefore, recurring concerns in this collection of essays and speeches."

Sean Carroll explores how evolution has shaped nature's wondrous complexity and diversity, from insects to octopuses, from mice to men. We not only share nearly 99% of our genes with chimps, we also have some 35% in common with daffodils. Throughout much of the animal and even plant kingdoms, almost the same ancient genes code for almost the same proteins. And further, to everyone's astonishment, the genes involved in making the complex eyes of fruitflies are close matches to those involved in making the very different eyes of octopuses and people. So what leads to the nature's 'endless forms most beautiful'? The key to this mystery is being unravelled by 'Evo Devo' or the new science of evolutionary development biology. By looking at how a single-celled egg gives rise to a complex, multi-billion celled animal, Evo Devo is illuminating exactly how new species - butterflies and zebras, trilobites and dinosaurs, apes and humans - are made and evolved. The key, it turns out, is all about location and timing... For anyone who has ever pondered 'where did I come from', Endless Forms Most Beautiful explores our history, both the journey we have all made from egg to adult, and the long trek from the origin of life to the very recent origin of our species.

You are what you eat - or are you? What is in food? Where does it come from? Richard Lacey, Professor of Clinical Microbiology at Leeds University and a popular media critic on food issues, takes the reader on a culinary exploration into the world of food. Blending science and humour, he stimulates us to question the future and to think about the nature of what we eat and where it comes from. Richard Lacey is on the side of the consumer, you and me, as he reveals the sinister side of food production and the dangers lurking in the kitchen. The reader is served up with a feast of practical tips on the handling of food. But food is FUN too! Our taste buds work overtime as we are shown how to enjoy food that is delicious, healthy and safe. The overall message is enjoy your food but be aware of the dangers and take care. As you read you will laugh, wince and learn about FOOD.

A razor-sharp analysis of how record-breaking exploits in extreme sport are redefining the limits of being human. Right now, more people are risking their lives for their sports then ever before in history. As Thomas Pynchon once put it in Gravity's Rainbow, 'it is not often that Death is told so clearly to f@%* off'. Over the past three decades, the bounds of the possible in action and adventure sports - from sky-diving to motocross to surfing and beyond - have been pushed farther and faster. A generation's worth of iconoclastic misfits have rewritten the rules of the feasible; not just raising the bar, but obliterating it altogether. Along the way, they have become a force pushing evolution relentlessly onward. In a thrilling narrative that draws on biology, psychology, and philosophy, Steven Kotler asks why, at the tail end of the 20th century and the early portion of the 21st, are we seeing such a multi-sport assault on reality? Did we somehow slip through a wormhole to another universe where gravity is optional and common sense obsolete? And where - if anywhere - do our actual limits lie?