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Pharmacodynamic Models of Selected Toxic Chemicals in Man - Volume 2: Routes of Intake and Implementation of Pharmacodynamic Models (Paperback, Softcover reprint of the original 1st ed. 1986)
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Pharmacodynamic Models of Selected Toxic Chemicals in Man - Volume 2: Routes of Intake and Implementation of Pharmacodynamic Models (Paperback, Softcover reprint of the original 1st ed. 1986)
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This report contains the results of a study undertaken by
Associated Nuclear Services (ANS) for the Directorate General of
Employment, Social Affairs and Education of the Commission of the
European Communities (CEC). This study was entitled "Dynamics of
Selected Toxic Materials in Man." vii 2 Summary This report
presents results from the second phase of a study on the metabolism
of selected actual and potential human carcin ogens. In the first
phase of this work a comprehensive review of literature relating to
the metabolism of these materials was under taken and
pharmacokinetic models were proposed to represent that meta bolism.
It was suggested that these models, and the reviews on which they
were based, would provide information relevant to the development
of monitoring programmes and in the interpretation of dose-response
data. In the second phase of the study, attention has been concen
trated on the implementation of the models proposed for the various
substances reviewed, i.e. arsenic, beryllium, cadmium, lead,
nickel, chromium, asbestos, benzene, vinyl chloride monomer,
benzidine and its congeners, carbon tetrachloride and methyl
iodide. However, this programme has been supplemented by an
on-going review of the relevant literature on these substances and
a detailed analysis of the applica bili ty of the pharmacokinetic
models used for the organs of intake, i.e. the lung and
gastrointestinal tract."
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