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Books > Medicine > Other branches of medicine > Pharmacology
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Structure-based Design of Drugs and Other Bioactive Molecules - Tools and Strategies (Hardcover)
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Structure-based Design of Drugs and Other Bioactive Molecules - Tools and Strategies (Hardcover)
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In contrast to previous texts focusing on either computational,
structural or synthetic methods, this one-of-a-kind guide
integrates all three skill sets for a complete picture of
contemporary structure-based design.
As a result, this practical book demonstrates how to develop a
high-affinity ligand with drug-like properties for any given drug
target for which a high-resolution structure exists. The authors,
both of whom have successfully designed drug-like molecules that
were later developed into marketed drugs, use numerous examples of
recently developed drugs to present best practice in
structure-based drug design with the novice in mind. By way of a
carefully balanced mix of theoretical background and case studies
from medicinal chemistry applications, readers will quickly and
efficiently master the basic skills of successful drug design.
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