A simple and sensitive spectrophotometric method has been developed
for the determination of clarithromycin in pure and commercial
pharmaceutical formulations. The method involves formation of
colored ion-associate complex of clarithromycin with bromothymol
blue in acidic media (acetate buffer solution). The colored complex
was extracted in chloroform which showed the optimum wavelength at
420 nm. Various conditions such as wavelength, acetate buffer pH,
acetate buffer volume, bromothymol blue solution concentration and
bromothymol blue solution volume were investigated. At the optimum
conditions, the method has been applied for the determination of
clarithromycin in commercial pharmaceutical formulations. The
investigated spectrophotometric method has numerous advantages, for
examples, the use of inexpensive chemicals, sensitivity and
reproducibility and can be used as alternatives for routine
analysis of clarithromycin.
General
| Imprint: |
Lap Lambert Academic Publishing
|
| Country of origin: |
United States |
| Release date: |
November 2012 |
| First published: |
November 2012 |
| Authors: |
Ahmad Waqar
• Shahid Kashif
|
| Dimensions: |
229 x 152 x 4mm (L x W x T) |
| Format: |
Paperback - Trade
|
| Pages: |
64 |
| ISBN-13: |
978-3-659-30666-2 |
| Categories: |
Books >
Medicine >
General issues >
General
|
| LSN: |
3-659-30666-5 |
| Barcode: |
9783659306662 |
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