"Fifteen years ago, many questioned the wisdom of sequencing the
human genome. There were concerns not only about the technical
feasibility of such an effort, but also that its scientific worth
would prove too modest to warrant the investment of human and
financial capital that the project would require. This collection
of essays stands as eloquent testimony to those who overcame such
doubts to create, nurture, and finish the sequencing of the human
genome in April 2003, a date that will forever stand out in human
history. The wide and public availability of the human genome
sequence and the other tools spawned by the Human Genome Project
have helped to create an unparalleled era of biomedical discovery.
It has opened up new avenues for the understanding of the biology
of human health and disease. Many of these avenues remain to be
fully explored, but this volume already demonstrates that
information about genetics and genomics is increasingly permeating
our clinical approach to patients."--from the Foreword by Dr. Elias
Zerhouni
For more than a century, knowledge about the role of genes has
been gradually reshaping perceptions of our health and of
ourselves. From Mendel's work with plants and Watson and Crick's
model of DNA's double-helix structure to the recent decoding of the
human genome, the tremendous advances in our ability to analyze and
interpret gene sequences are revolutionizing many aspects of
medicine. Genomic Medicine collects and updates an acclaimed series
of articles published in the pages of the New England Journal of
Medicine since November 2002 that together provide an authoritative
and comprehensive overview of the latest developments in the field
of medical genetics and an exploration of where these advances
might take medicine over the next decade.
Beginning with a fundamental primer and a useful glossary of
terms, the book offers the latest information on the use of
genetics to screen, diagnose, and treat a wide variety of diseases,
including breast and ovarian cancer and cardiovascular, Alzheimer,
and Parkinson disease. Also included are discussions of population
screening, pharmacogenetics, and the ethical, legal, and social
dimensions of genomic medicine. Edited by leaders in the field,
written by experts from around the globe, and brimming with
full-color illustrations, Genomic Medicine is an indispensable
guide to the full potential of the DNA-based transformation of
medicine.
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