Absorption, Distribution, Metabolism and Excretion (ADME) processes
and their relationship with the design of dosage forms and the
success of pharmacotherapy form the basis of this upper level
undergraduate/graduate textbook. As an introduction oriented to
pharmacy students, it is also written for scientist from different
fields outside of pharmaceutics. (e.g. material scientist, material
engineers, medicinal chemists) who might be working in a positions
in pharmaceutical companies or whose work might benefit from basic
training in the ADME concepts and some biological background.
Pedagogical features such as objectives, keywords, discussion
questions, summaries and case studies add valuable teaching tools.
This book will provide not only general knowledge on ADME processes
but also an updated insight on some hot topics such as drug
transporters, multi-drug resistance related to pharmacokinetic
phenomena, last generation pharmaceutical carriers
(nanopharmaceuticals), in vitro and in vivo bioequivalence studies,
biopharmaceuticals, pharmacogenomics, drug-drug and food-drug
interactions, and in silico and in vitro prediction of ADME
properties. In comparison with other similar textbooks, around half
of the volume would be focused on the relationship between
expanding scientific fields and ADME processes. Each of these
burgeoning fields has a separate chapter in the second part of the
volume, and was written with leading experts on the correspondent
topic, including scientists and academics from USA and UK (Duquesne
University School of Pharmacy, Indiana University School of
Medicine, University of Utah College of Pharmacy, University of
Maryland, University of Bath). Additionally, each of the initial
chapters dealing with the generalities of drug absorption,
distribution, metabolism and excretion would include relevant,
classic examples related to each topic with appropriate
illustrations (e.g. importance of active absorption of levodopa,
implications in levodopa administration, drug drug interactions and
food drug interactions emerging from the active uptake;
intoxication with paracetamol as a result of glutathione depletion,
CYP induction and its relationship with acute liver failure caused
by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is
written as a core textbook for ADME processes, pharmacy,
pharmacokinetics, drug delivery, biopharmaceutics, drug
disposition, drug design and medicinal chemistry courses.
General
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