Trophoblasts (from Greek trephein: to feed, and blastos:
germinator) constitute a particular population of cells forming the
outer layer of the blastocyst, providing the embryo with nutrients
and giving rise to the outer chorionic sac and the foetal component
of the placenta. The trophoblast facilitates embryonic implantation
via its inner layer of mononuclear cytotrophoblasts and its outer
layer of multinuclear cytoplasm, the syncytiotrophoblasts, forming
the early connections between the embryo and the maternal
endometrium. The cells of the trophoblast have many qualities,
exhibit important functions and have an important role in the
development of the placenta; also, they work as a regulator during
early growth of the embryo. This volume provides a detailed summary
of knowledge regarding the development of the trophoblast during
the First Trimester of Pregnancy, the process of placenta apoptosis
and the factors causing aging of the placenta. The pathology of
trophoblast can manifest itself in several clinical conditions
during pregnancy such as intrauterine foetal growth restriction
(IUGR), gestational trophoblastic disease and pre-eclampsia. The
analysis of the pathogenetic mechanisms involved in these critical
conditions are discussed in this book. These aspects are analysed
with scientific methodology on the basis of updated studies.
"Development of Human Trophoblast" can be considered a reference
book for every pathologist, obstetrician and resident.
General
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