Nanotechnology will serve as multifunctional tools that will not
only be used with any number of diagnostic and therapeutic agents,
but will change the very foundations of cancer diagnosis,
treatment, and prevention. Cancer is a genetically rooted disease
that involves the simultaneous occurrence of two general categories
of cellular malfunctions. Ligand-mediated targeting of anticancer
therapeutics is being explored utilizing he potential of
Nanotechnology. The basic principle underlies ligand-targeted
therapeutics is that the delivery of antineoplastic drugs to cancer
cells- or cancer-associated tissues such as tumor vasculature can
be selectively increased by associating the drugs with molecules
that bind to antigens or receptors that are either uniquely
expressed or over-expressed on the target cells relative to normal
tissues. This allows specific delivery of drugs bound with
nanoparticles to the cancer cells. This concept is utilized in the
study presented in this book. Con-A, a plant lectin is employed
here as a ligand which guides the SLN's bearing anticancer drug to
the target tumor vasculature. The study summarizes the effective
potential of SLN's in suppressing tumor.
General
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