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Innovation on Stomach Targetting Floating Tablets (Paperback)
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Innovation on Stomach Targetting Floating Tablets (Paperback)
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Various approaches have been paused to increase the duration of
oral dosage form in the stomach, including floating systems,
swelling and expanding system, modified shape system, high density
systems and other delayed gastric emptying devices. (Magnetic
systems, Super porous -biodegradable hydrogel systems).
Hydrodynamically balanced systems (HBS) -incorporated buoyant
materials enable the device to float. Raft systems incorporate
alginate gels - these have a carbonate component and, upon reaction
with gastric acid, bubbles form in the gel, enabling floating.
Swelling type of dosage form are such that after swelling, this
product swell to extent that prevent their exit from the stomach
through the pylorus. As, a result, the dosage form retained in the
stomach for a longer period of time. These systems may be referred
to as a "Plug type system," since they exhibit tendency to remain
logged in the pyloric sphincters.
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