For drugs with a narrow therapeutic index, therapeutic drug
monitoring methods are essential for patient management. Although
immunoassays are commercially available for many drugs and most
laboratories use these assays for routine therapeutic monitoring,
they have many limitations which hinder their efficacy. Providing
practical guidelines for implementing preferred gas and liquid
chromatographic methods, Advances in Chromatographic Techniques for
Therapeutic Drug Monitoring is a comprehensive reference describing
the theory and application of therapeutic drug monitoring in
clinical laboratories.
Edited by a distinguished authority in the field and containing
contributions from a variety of experts, the book discusses
preanalytical variables, the pitfalls of immunoassays, tandem mass
spectrometry, issues related to pain management and herbal
supplements, and therapeutic drug monitoring for a range of
medications, including:
- Anticonvulsants
- Digitalis
- Cardioactive drugs
- Antidepressants
- Immunosuppressants
- Anti-cancer drugs
- Vancomycin and aminoglycosides
- Antibiotics
- Antiretroviral drugs
- Nonnarcotic analgesics
- Anti-inflammatory drugs
Examing older and newer drugs, the book contains detailed
discussions on the rationale for therapeutic drug monitoring of
each class of drugs, along with their basic pharmacology and
toxicology. An extensive list of references is provided at the end
of each chapter so that those interested in implementing a new drug
assay can find the most appropriate method for the intended
drug.
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