Selective Estrogen Receptor Modulators - Research and Clinical Applications (Paperback, Softcover reprint of the original 1st ed. 2002)

Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Contemporary Endocrinology
Release date:	December 2012
First published:	2002
Editors:	Andrea Manni • Michael Verderame
Dimensions:	254 x 178 x 20mm (L x W x T)
Format:	Paperback
Pages:	374
Edition:	Softcover reprint of the original 1st ed. 2002
ISBN-13:	978-1-4684-9665-9
Categories:	Books > Medicine > Clinical & internal medicine > Endocrinology > General
LSN:	1-4684-9665-4
Barcode:	9781468496659

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