Genomic Imprinting - Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2002)

Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 181
Release date:	November 2010
First published:	2002
Editors:	Andrew Ward
Dimensions:	229 x 152 x 20mm (L x W x T)
Format:	Paperback
Pages:	377
Edition:	Softcover reprint of hardcover 1st ed. 2002
ISBN-13:	978-1-61737-164-6
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
LSN:	1-61737-164-5
Barcode:	9781617371646

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