There are several reasons for the attractiveness of modified
release dosage forms. For many disease states, a number of
therapeutically effective compounds already exist. The goal in
designing sustained or controlled delivery systems is to reduce the
frequency of dosing and/or to increase the effectiveness of the
drug by localization at the site of action, reducing the dose
required or providing the uniform drug delivery. These systems have
the obvious advantages of ease of administration and patient
acceptance. Because of flexibility of dosage form design and their
testing, oral sustained release systems have received a great deal
of attention. The cost of formulation development, raw materials
and manufacturing are significant factors in choosing formulation
techniques and materials. The objective of this book is to discuss
in a qualitative sense some of the advantages and challenges of
Gastroretentive Drug Delivery Systems in comparison to controlled
release formulations and to consider some contentious issues
regarding the feasibility for Gastroretentive Drug Delivery systems
for certain drugs. Attention will focus primarily on Oral
Controlled RDDS.
General
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