I had studied development aspects of sustained release microspheres
of Diclofenac sodium that release the drug Up to 24 hour and
improve Bioavailability of Diclofenac Sodium by using spray drying
and simple solvent evaporation technique.Preparation of Chitosan
Microsphere with Diclofenac Sodium by various techniques such as
spray drying and simple solvent evaporation technique. For Spry
Drying technique the optimization of Spry Dried Parameter such as
inlet Temperature and Feed pump Rate. Optimization of Temperature
by taking the 130 degree C, as a starting Temperature and showing
the Characteristic of Microspheres. Study Shows that the fine
Partical were found in 150 degree C. Temperature, Feed Pump rate
was also optimizes by this way and 2ml/min feed pump rate shows
good Microspheres with higher %yield. So parameters were taken 150
degree C temperature and 2ml/min feed pump rate and Microspheres
were Prepared. Further study with Drug to polymer ratio like
1:1,1:3 and 1:5 are carried out.As increase in the drug to polymer
ratio from 1:1,1:3 and 1:5 the Entrapment efficiency was also
increase and the release rate were Extended.
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