Epigenetics is defined as heritable changes that do not affect the
DNA sequence but influence gene expression. Epigenetic changes
occur at the levels of DNA, histone, protein, and chromatin
structures. Proper epigenetic modifications are essential for cell
differentiation and function during development, while some
epigenetic modifications are passed on from parents to offspring
through gametes. Therefore, alterations of epigenetic states would
have serious consequences for human development and health. This
realization and the advent of new technologies have encouraged the
advance of epigenetic studies in recent years. Nonetheless, many
aspects of epigenetics, such as regulatory mechanisms and
evolutional advantages, remain to be better understood.Written by
26 scientists at the forefront of epigenetics research, this book
discusses the different facets of epigenetics: from gametogenesis
to child development, as well as from mechanistic studies in animal
models to reviews of human clinical data.
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