"Next generation" sequencing techniques allow for more detailed
analysis of exons and introns in multiple genes at the same time.
This will reveal many mutations that potentially lead to exon
skipping. To functionally test these a lot can be achieved with a
limited set of protocols, while for the intentional induction of
exon skipping different tools and target genes are involved and the
translational path from in vitro splicing to in vivo tests in
animal models requiring a more extensive set of protocols. Exon
Skipping: Methods and Protocols provides scientist with a
comprehensive guide to many of the methods and techniques used for
exon skipping, such as methods on how to discriminate "real
polymorphisms" from mutations that affect splicing. Written in the
highly successful Methods in Molecular Biology (TM) series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and key tips on troubleshooting
and avoiding known pitfalls. Authoritative and practical Exon
Skipping: Methods and Protocols seeks to aid scientists in the
continuing study of exon skipping.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Molecular Biology, 867 |
| Release date: |
August 2016 |
| First published: |
2012 |
| Editors: |
Annemieke Aartsma-Rus
|
| Dimensions: |
254 x 178 x 23mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
440 |
| Edition: |
Softcover reprint of the original 1st ed. 2012 |
| ISBN-13: |
978-1-4939-6206-8 |
| Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Medical genetics
|
| LSN: |
1-4939-6206-X |
| Barcode: |
9781493962068 |
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