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Insignificant Anticancer Activity of Novel Pyrimidine Derivatives (Paperback)
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Insignificant Anticancer Activity of Novel Pyrimidine Derivatives (Paperback)
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Cancer is one of the most life threatening diseases and possess
many health hazard in both developed and developing countries.
Leukemia is one of the most common cause of cancer occur throughout
the world due to the lack of effective chemotherapeutic agents and
side effects of anticancer drugs on prolong therapy of
chemoprevention so anticancer patients switch over to the herbal
medicine for their cure. Pyrimidines are the class of heterocyclic
compound of pharmaceutical importance compound having pyrimidine
ring moiety are associated with fungicidal, antibacterial,
analgesic, anti-inflammatory, anti-HIV, and anti-tumor activity.
The compound prepared by the Knoevenagel and Claisen-schmidt
condensation. The chemical structures were confirmed by different
spectral techniques. The data of these synthesized compounds were
submitted to National Institute of Health, USA under the drug
discovery programmed of NCI (National Cancer Institute) and
screened for anticancer activity at a single high dose (10-5 M) in
full NCI 60 cell lines. The compound
3-(2-amino-6-(3-chlorophenyl)-pyrimidin-4-yl)-2H-chromen-2-one
found to be most efficient anticancer activity with selective
influence on brea
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