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Books > Medicine > Other branches of medicine > Pharmacology
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Selective Estrogen Receptor Modulators - A New Brand of Multitarget Drugs (Paperback, 2006 ed.)
Loot Price: R3,030
Discovery Miles 30 300
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Selective Estrogen Receptor Modulators - A New Brand of Multitarget Drugs (Paperback, 2006 ed.)
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The increasing awareness on the varied consequences of hypogonadism
in distinct organs and systems has supported the notion of
estrogens as systemic agents. This observation is congruent with
the variety of tissues affected by - trogens when used in hormone
therapy formulations on hypogonadic women. Apart from the genital
tract and the breast, recognized as traditional targets for
estrogens, the skeleton, the vascular tree, or the central nervous
system, are good examples of territories that have demonstrated
sensitivity to estrogens. This evidence has created great interest,
as shown by the great amount of lit- ature that has been produced
on the bene?ts and risks associated with the use of estrogens. In
parallel to the clinical interest, basic research has improved our
kno- edge on the complexities involved in estrogen action at the
molecular level. Together with effects mediated through speci?c
receptors, a concept that has been the mainstay of the
interpretation of estrogen action for years, there is enough
evidence to hold the notion of receptor-independent effects. The
substantial advances in modern technology applied to research have
helped in enlightening the particulars of this versatile action of
estrogens. This more detailed knowledge on the sophisticated
mechanism of action of estrogens has nourished the emergence of
multiple hypotheses speculating with the p- sibility of
manipulating estrogen action. The notion that a widely extended
regulatory system of cell function, as it is the estrogen receptor
machinery, might be modulated at wish has arisen as an attractive,
although still elusive postulate.
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