Since the discovery of LHRH in 1971, research into the physiology
and therapeutics of this compound can be divided into three dis
tinctly different phases. In the first phase, attention was paid
chiefly to the natural sequence hormone; efforts were channeled to
explore its diagnostic use; and nearly all the clinical
investigations were coordinated by a single pharmaceutical company.
The successes in this area were quite limited and the interest in
the promise of this agent as a diagnostic test has long since
waned. This phase of research con sumed roughly the first seven
years of clinical testing after the isolation and characterization
of the compound by the two groups involved in the Nobel effort.
With the appearance of long-acting LHRH agonists, the second phase
of research on LHRH began in the late '70's. LHRH agonists were the
only compounds available during this period of research and
paradoxical desensitization was the predominant therapeutic basis
for the discoveries. An ever-widening number of therapeutic
applications using this approach were unearthed. A second theme
which emerged during this second 5-7 year period was that the
pulsatile administration of the natural sequence LHRH could be used
to treat LHRH deficiency in men and women."
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