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Atypical Antipsychotics (Hardcover, 2000 ed.)
Loot Price: R5,570
Discovery Miles 55 700
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Atypical Antipsychotics (Hardcover, 2000 ed.)
Series: Milestones in Drug Therapy
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The introduction of chlorpromazine in 1953, and haloperidol in
1958, into clinical practice dramatically altered the therapy of
schizophrenic patients. Although representing by no means a cure
for this severe psychiatric ill ness, it allowed, for the first
time, to adequately control the severe hallu cinations and
delusional beliefs which prevent these patients from leading a more
or less independent life. Indeed these antipsychotics (and the many
congeners that were to follow) significantly reduced the number
ofchronic schizophrenic inpatients in psychiatric clinics all over
the world. However soon after their introduction it became clear
that, like all other available drugs, antipsychotics were by no
means miracle drugs. In fact, two major problems appeared. First,
the antipsychotics had very little effect on the so-called negative
or defect symptoms, like social isolation, apathy and anhedonia,
and secondly virtually all antipsychotics produced a number of
side-effects, of which the neurological (often called extra
pyramidal) side-effects were the most troublesome. Especially the
tardive dyskinesia, which occurred in about 15 to 20% of the
patients after pro longed treatment, represented a major problem in
the treatment of schizo phrenic patients."
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