Oral drug delivery has been known for decades the most widely
utilized route for administration among all the route that have
been explored for systemic delivery of drugs via various
pharmaceutical products of different dosage forms. The reasons that
the oral route has achieved such popularity may be in part
attributed to its ease of administration as well as the traditional
belief that by oral administration the drug is well absorbed as the
food stuffs that are ingested daily. In fact, the development of a
pharmaceutical product for oral delivery, irrespective of its
physical form involves varying extents of optimization of dosage
form characteristics within the inherent constraints of GI
physiology. Therefore, a fundamental understanding of various
disciplines, including GI physiology, pharmacokinetics,
pharmacodynamics and formulation design are essential to achieve a
systemic approach to successful development of an oral
pharmaceutical dosage form. The more sophisticated a delivery
system, the greater is the complexity of these various disciplines
involved in the design and optimization of the system. In any case,
the scientific framework required for the successful development.
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