The germfree animal is reared in the laboratory to be bacteria
free; its counterpart, the gnotobiotic animal, is exposed to select
microorganisms. The need for such an animal model for use in
biomedical studies was first expressed by Pasteur in the late
1800s. Subsequent development of germfree and gnotobiotic animals
led to an explosion of studies on the effects of microflora and its
components on the physiology and metabolism of the host. Germfree
and Gnotobiotic Animal Models brings together the most notable
points of early and recent studies and gives reference to the most
pertinent literature.
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