This book deals with pathophysiology and pharmacology of spontaneously hypertensive rats (SHR) and describes new trends in SHR research from hemodynamic characteristics to immunological views. It is devoted to the use of tissue culture studies to elaborate SHR characteristics.

Maintaining its user-friendly approach, The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition is a handy guide for members of the laboratory animal community looking for a concise, descriptive introduction to what an IACUC is all about and how it operates. The book covers training programs and discusses professional certifications for IACUC administrative and animal care staff. It provides pointers to principal investigators, discusses interactions between IACUCs and other compliance panels, and addresses occupational health and safety programs and the role they play in the overall animal care and use program. This new edition of a bestseller contains new information on international regulations regarding animal subject research and the requirements for an ethics panel review. It discusses outside collaborations, interinstitutional memorandums of understanding, and the differences in regulations between countries. The book also includes a new chapter exploring semiannual program reviews, semiannual inspections, and postapproval monitoring. The contributors provide updated information on the protocol submission process, electronic protocol management systems, and records management-including the essential elements of the protocol form and how to complete it. The book also delves deeply into bioethics. It discusses how IACUCs can ensure that each proposal to use animals in research includes an ethical review with a harm-benefit analysis weighing the expected advancements in human and animal health against the potential harm inflicted to the animal. Also included is a chapter on how to survive a regulatory inspection or an accreditation site visit. All interpretations of the regulations have been reviewed by staff at the NIH Office of Laboratory Animal Welfare (OLAW), the Animal Welfare Information Center (AWIC), and USDA APHIS/Animal Care (AC) for consistency and compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR).

Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine's acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.

Praise for the Previous Editions "The author brings in management wisdom from the world outside laboratory animal medicine and veterinary medicine. As a result, there is a rich mixture of the experience of a seasoned professional and the theoretical framework used by schools of management .... I recommend this book to managers and laboratory animal specialists at any stage of their careers." -Franklin M. Loew, DVM, PhD, DACLAM, JAVMA, Vol. 222, No. 6, 2003 "... This book is a good informational resource for any new manager to the field of laboratory management. The information is presented in a way that will keep your interest and stimulate you to think how it can benefit you and the facility in which you work." -Susan K. Cutter, BS, RVT, RLATG, Purdue University, West Lafayette, Indiana, USA, LAMA Review Written in Jerry Silverman's trademark style, Managing the Laboratory Animal Facility, Third Edition provides the reader with sound management theory and associated management practices that are easy to read, easy to understand, easy to implement, and pertinent to the daily management and leadership of laboratory animal facilities. Maintaining the practical focus of previous editions, this greatly expanded volume presents the critical knowledge needed to help you make efficient and effective use of the key resources that are used every day by vivarium managers - people, time, money, and information. New to the Third Edition Incorporating the latest developments in management theory and application, the edition contains approximately 100 pages of new and expanded material. This more detailed coverage: Discusses lean management concepts and practices and their application to laboratory animal science Adds information on many essential topics, especially in human resources management in its treatment of negotiations, influence, and performance reviews Provides a large number of revisions and updates to Appendix 2 in its presentation of Per diem calculations Includes an extensive list of references for further study of specialized topics

Learn the veterinary technician's role in the care of exotic pets and animals used in biomedical research! Laboratory Animal and Exotic Pet Medicine: Principles and Procedures, 3rd Edition helps you gain the knowledge and skills needed to ensure animal health and well-being. It covers animal husbandry, restraint and handling, and diseases, and provides guidelines to key clinical procedures such as blood collection, medication administration, anesthesia, and diagnostic imaging. Research-related information addresses the ethical concerns of exotic pet ownership, as well as the benefits and humane use of animals in research. Written by noted veterinary technology educator Margi Sirois, this text is a must-have resource for all caretakers of lab animals. Comprehensive coverage prepares you to work with all types of animals by addressing a wide variety of species including rats, mice, rabbits, guinea pigs, ferrets, hamsters, gerbils, nonhuman primates, amphibians, fish, reptiles, birds, farm animals, and cats and dogs; it also covers topics such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations. Consistent organization of each species chapter makes it easy to quickly identify similarities and differences among various laboratory animals. Current information on legal, moral, and ethical issues includes legal requirements, the protocols guiding lab animal use, animal exploitation, and animal rights. Discussion of specific uses for each species in biomedical research provides a perspective that helps you explain the benefits of animal use in providing high-quality research data. Technician Notes highlight important points and provide helpful tips to improve your knowledge and skills. Learning objectives, key points, and chapter review questions make studying easier. NEW! Comprehensive coverage of poultry includes the increasingly popular backyard chickens, as well as commonly performed procedures and in-depth information on housing, restraint, nutrition, common diseases, diagnostics, and therapeutics. NEW photographs show the latest technology available in laboratory and exotic animal medicine.

Written by the international community's leading experts, Trace Elements in Laboratory Rodents describes the best and most current methods to provide deficient or supplemental trace elements to laboratory animals, as well as how to assay them. The experts warn of the common pitfalls and hidden problems in nutritional testing and how to avoid them. This how-to approach focuses on the technical details that make good, reliable studies. Common as well as rare or recently recognized minerals are described relating to both dietary supplementation and measurement in tissues.
If you are a researcher, professor, or student working in nutrition, food science, biochemistry, or veterinary medicine, you can't afford to be without this excellent hands-on methods manual!

Praise for the Previous Editions "The author brings in management wisdom from the world outside laboratory animal medicine and veterinary medicine. As a result, there is a rich mixture of the experience of a seasoned professional and the theoretical framework used by schools of management .... I recommend this book to managers and laboratory animal specialists at any stage of their careers." -Franklin M. Loew, DVM, PhD, DACLAM, JAVMA, Vol. 222, No. 6, 2003 "... This book is a good informational resource for any new manager to the field of laboratory management. The information is presented in a way that will keep your interest and stimulate you to think how it can benefit you and the facility in which you work." -Susan K. Cutter, BS, RVT, RLATG, Purdue University, West Lafayette, Indiana, USA, LAMA Review Written in Jerry Silverman's trademark style, Managing the Laboratory Animal Facility, Third Edition provides the reader with sound management theory and associated management practices that are easy to read, easy to understand, easy to implement, and pertinent to the daily management and leadership of laboratory animal facilities. Maintaining the practical focus of previous editions, this greatly expanded volume presents the critical knowledge needed to help you make efficient and effective use of the key resources that are used every day by vivarium managers - people, time, money, and information. New to the Third Edition Incorporating the latest developments in management theory and application, the edition contains approximately 100 pages of new and expanded material. This more detailed coverage: Discusses lean management concepts and practices and their application to laboratory animal science Adds information on many essential topics, especially in human resources management in its treatment of negotiations, influence, and performance reviews Provides a large number of revisions and updates to Appendix 2 in its presentation of Per diem calculations Includes an extensive list of references for further study of specialized topics

Brute Science investigates whether biomedical research using animals is, in fact, scientifically justified. Hugh LaFollette and Niall Shanks examine the issues in scientific terms using the models that scientists themselves use. They argue that we need to reassess our use of animals and, indeed, rethink the standard positions in the debate.

Maintaining its user-friendly approach, The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition is a handy guide for members of the laboratory animal community looking for a concise, descriptive introduction to what an IACUC is all about and how it operates. The book covers training programs and discusses professional certifications for IACUC administrative and animal care staff. It provides pointers to principal investigators, discusses interactions between IACUCs and other compliance panels, and addresses occupational health and safety programs and the role they play in the overall animal care and use program. This new edition of a bestseller contains new information on international regulations regarding animal subject research and the requirements for an ethics panel review. It discusses outside collaborations, interinstitutional memorandums of understanding, and the differences in regulations between countries. The book also includes a new chapter exploring semiannual program reviews, semiannual inspections, and postapproval monitoring. The contributors provide updated information on the protocol submission process, electronic protocol management systems, and records management-including the essential elements of the protocol form and how to complete it. The book also delves deeply into bioethics. It discusses how IACUCs can ensure that each proposal to use animals in research includes an ethical review with a harm-benefit analysis weighing the expected advancements in human and animal health against the potential harm inflicted to the animal. Also included is a chapter on how to survive a regulatory inspection or an accreditation site visit. All interpretations of the regulations have been reviewed by staff at the NIH Office of Laboratory Animal Welfare (OLAW), the Animal Welfare Information Center (AWIC), and USDA APHIS/Animal Care (AC) for consistency and compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR).

Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.

Judge Your Practices Against This Benchmark Manual COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups' findings, The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research provides a consensual European view of best practices for individuals and institutions caring for and working with laboratory animals. What is COST? COST (European Cooperation in Science and Technology) is an intergovernmental initiative that promotes coordination of nationally funded science and research at a European level. This book focuses on reduction and refinement strategies and includes insightful contributions from 44 experts drawn from various EU countries. Addressing only the most commonly used mammalian species-rats, mice, and rabbits-each chapter of the book follows a similar structure: * Objectives outline the breadth of the chapter's coverage * Key Factors summarize the central issues that underpin good practice * Questions Unresolved close each chapter, identifying areas of uncertainty and prompting investigations directed at advancing knowledge and application within relevant fields The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research is the reference sure to be found in the lab coats of those responsible for the care and welfare of animals and those overseeing and conducting activities related to the use of animals for scientific purposes.

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics: General Approaches for Critical Care Critical Care Management for Laboratory Mice Critical Care Management for Laboratory Rats Special Considerations for Critical Care Management in Laboratory Rodents Resources and Additional Information The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

Experimentation on animals and particularly humans is often assumed to be a uniquely modern phenomenon. But the ideas and attitudes that encourage the biological and medical sciences to experiment on living creatures date from the earliest expression of Western thought. In "Animal and Human Experimentation," Anita Guerrini looks at the history of these practices from vivisection in ancient Alexandria to present-day battles over animal rights and medical research employing human subjects.

Guerrini discusses in-depth key historical episodes in the use of living beings in science and medicine, including the discovery of blood circulation, the development of smallpox and polio vaccines, and recent AIDS research. She also explores the rise of the antivivisection movement in Victorian England, the modern animal rights movement, and current debates over gene therapy. In this highly accessible text, we learn how our understanding of an animal's capacity to feel pain has evolved. Guerrini reminds us that the ethical values of science seldom stray far from those of the society in which scientists live and work.

Ethical questions about the use of animals and humans in research remain among the most vexing within both the scientific community and society at large. These often rancorous arguments have gone on, however, with little awareness of their historical antecedents. "Animal and Human Experimentation" offers students and concerned general readers on every side of this debate a context within which to understand more fully the responsibility we all bear for the suffering inflicted on other living beings in the name of scientific knowledge.

...this is an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research...This book represents a benchmark achievement for this technique...it will become the standard for many years to come. - Paul Baldrick, British Toxicology Society Newsletter

The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies’ differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.

Animal experimentation is one of the most controversial areas of debate on animal rights. Biomedical research is at the hard edge of these debates: it throws up fundamental questions of moral value - of whether human life is more important than that of animals. Much experimentation is defended by its apparent success in terms of increasing medical knowledge. This study investigates whether biomedical research using animals is, in fact, scientifically justified. The authors show that in scientific terms - using the models that scientists themselves use - these claims are exaggerated, or even false. They argue that we need to reassess our use of animals and, indeed, rethink the standard positions in the debate. Their analysis reveals why research using animals might be a source of hypotheses about human biomedical phenomena, yet would never prove or establish anything about this phenomena.

The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Rodents are the most commonly used species in biomedical research. Individuals conducting rodent research are often responsible to ensure that all areas of anesthesia and analgesia are performed humanely. Anesthetic agent selection, anesthetic monitoring, and postoperative pain assessment and management are essential to the institutional animal care and use program and contribute significantly to the 3Rs by reducing pain and/or distress and refining various procedures. The Handbook of Laboratory Animal Anesthesia and Pain Management: Rodents is the first book to capture multiple advances in this important area that greatly impacts various experimental methodologies. Richly illustrated in full color, the book serves as a quick reference source for investigators, veterinarians, technicians, and other animal caretakers charged with the care and use of rodents in a research setting. The unique format of this book also makes it extremely valuable to IACUC members, institutional officials, and occupational health and safety professionals. Key features: Presents practical information in easily accessible 'bullet point' format Covers anesthetic machine and related equipment, anesthetic management and monitoring, anesthesia and analgesia pharmacology, euthanasia, and record keeping Written by well-recognized experts in the laboratory animal community Provides extensive references to direct the reader to sources for further study of alternative techniques and their procedures Concludes with a thorough chapter on Regulatory Management of Rodent Anesthesia which has global application

The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of establishing and operating a germ-free mouse research facility, from basic principles and equipment to detailed instructions for assembling and maintaining isolators, sterilizing supplies, handling animals, and monitoring sterility. The book breaks down techniques and procedures into modules, each of which contains a step-by-step practical and visual guide to a set of related procedures. Each description consists of a materials list, introduction, and general overview, followed by a thoroughly illustrated walkthrough of the steps for each procedure. The descriptions end with troubleshooting tips. Technical chapters are heavily illustrated and include notations of potential pitfalls and alternatives. Other chapters discuss management procedures and practices such as the hiring and training of personnel, setting fee schedules, and record keeping. This book is a landmark resource for establishing and maintaining a facility for germ-free mouse research. Useful to both technicians and investigators, it presents every step necessary to establish a successful facility. It also gives direction in expanding multi-user facilities and applying new technologies to your current practices.

Suturing Principles and Techniques in Laboratory Animal Surgery: Manual introduces the basic principles of, and the materials and instruments required for, suturing and wound closure on animals in a research or veterinary facility. The manual provides descriptions and pictures portraying proper tissue handling and aseptic technique during wound closure, the correct hand placement and use of instruments, and the needle placement on the needle holder. The manual also provides in-depth coverage of various suture patterns and associated principles for proper knot tying, including step-by-step descriptions and handouts for each suture pattern. The downloadable resources provide descriptive narrative and step-by-step video demonstrations for each of the suturing techniques while portraying proper tissue handling and aseptic technique. Each suture pattern description includes the common name, principal use, and detailed instructions on how to complete the pattern. An audible narration accompanies the video clip for each suture pattern on the downloadable resources, with a written copy of the narration provided in the book along with each pattern description. The suture pattern handout includes the common name, principal use, brief pattern description, and sequential instructions for each pattern, accompanied by high-quality pictures. This manual and the accompanying downloadable resources help answer suture-related questions and aid readers in making educated decisions about basic wound closure.

Laboratory animals, including ferrets, play an important role in biomedical research and advances. The humane care and management of these animals remains an ongoing concern. Published in color to provide greater clarity to the techniques and concepts discussed, The Laboratory Ferret presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. The book presents a greater understanding of the use of the ferret in research, such as in studies on influenza. It is a valuable, handy reference for experienced individuals and for those without extensive training in working with ferrets.

Praise for the First Edition "This book is easy to read and has many informative illustrations...I would strongly recommend this book to those interested in a broad introduction to the care and use of laboratory guinea pigs as well as to laboratory animal technicians, managers, veterinarians and scientists who do not have direct access to large, well organized animal resource units with extensive library facilities." -John D. Young, Contemporary Topics The Laboratory Guinea Pig provides a compact and well- illustrated introduction to research on the guinea pig. The second edition of this popular handbook facilitates quick reference to the behavioral and physical traits of the guinea pig, as well as practical information on its unique anatomical and biological features. Numerous tables and color illustrations help the reader identify features of anatomy and understand health issues and care requirements. Supplying a stepwise introduction to common laboratory techniques, the new edition of this trusted reference provides guidance that supports the humane care and use of guinea pigs in the laboratory setting.

This bestseller has been an essential book for all those working with laboratory animals since it was first published in 1994. This fourth edition retains all the classic features that have made it a must-have reference including emphasis on best practice in order to improve animal welfare. The contents have been thoroughly updated and reorganised to make sure it is a really practical book for day-to-day use in the laboratory. The first section of the book covers principles applicable to all species, for example husbandry, handling and the education and training required by scientists and technical staff working with animals in the laboratory. Later chapters focus on specific species or groups of species.

New to this edition: - Reflects changes in European legislation and their impact on national legislation- Covers recommendations for the education and training of those carrying out animal experiments across Europe - New chapters on ethical considerations and balancing animal welfare with science- New information on environmental enrichment for laboratory animals- Covers advancements in anaesthesia and analgesia and techniques- Spiral bound for ease-of-use as a bench-top reference

This book is ideal for all personnel carrying out scientific procedures using animals, particularly during training and also for the new researcher. It will also be essential reading for study directors designing research programmes, animal technicians and veterinarians working with laboratory animal species.

Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory.

Emphasizes Humane Care and Use of Laboratory Swine

Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts:

• Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems
• Husbandry addresses housing, nutrition, sanitation, transportation, and more
• Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more
• Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management
• Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues
• Resources provides extensive references for further study, including handbooks, journals, and websites

The Laboratory Swine, Second Edition is ideal for animal caretakers, technicians, investigators, and laboratory animal veterinarians as a single-source reference that contributes to the humane care and use of swine in research.