Histone deacetylase inhibitors (HDIs) are good anti-cancer targets.
Histone acetyltransferases (HATs) and HDIs play opposite roles in
the regulation of gene expression via an epigenetic mechanism. HATs
catalyse the acetylation of lysine residues in histone tails,
facilitating and sustaining gene transcription. HDIs remove the
acetyl moieties from the epsilon-amine of lysine residues of
histone tails, leading to a more condensed form of chromatin and
preventing gene transcription. This book focuses on the use of HDIs
for the treatment of lymphoid malignancies; myeloid malignancies;
and breast cancer.
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