Nicotinic acid (NA) as lipid lowering agent drug has not become a
first-line treatment due to the strong side effect called flushing
occurs when given in immediate release dosage form. The tablets
were prepared by wet granulation method using HPMC K-15M, polymer
as retardant and the prepared tablets of NA will remain intact up
to 2 hrs in pH 1.2 due to Eudragit L 100-55 and its release is not
only initiated but tact fully retarded up to 12 hrs and were found
to be superior in physical properties, dissolution characteristics,
and drug content uniformity. The drug release from the matrix
tablet Fitted to the Higuchi model and Zero order release which
indicates non-Fickian diffusion.N8 showed good similarity with
theoretical profile of nicotinic acid. Excipients has significant
effect on drug release, because DCP retarded the release due to
hydrophobic nature, on the contrary MCC increased drug release for
its swelling property and causing burst release, and lactose
moderately affected drug release due to channeling action and hence
causing drug release at desired rate and amount. The studies
indicate that the formulation was effective in providing in vitro
release for extended perio
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!