Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Centenarians - An Example of Positive Biology (Hardcover, 1st ed. 2019)
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Centenarians - An Example of Positive Biology (Hardcover, 1st ed. 2019)
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This state-of-the-art review on longevity focuses on centenarians,
studied as a model of positive biology. The extraordinary rise in
the elderly population in developed countries underscores the
importance of studies on ageing and longevity in order to decrease
the medical, economic and social problems associated with the
increased number of non-autonomous individuals affected by
invalidating pathologies. Centenarians have reached the extreme
limits of human life span. Those in relatively good health, who are
able to perform their routine daily tasks, are the best examples of
extreme longevity, representing selected individuals in which the
appearance of major age-related diseases - including cancer and
cardiovascular diseases - has been consistently delayed or avoided.
The relationship between causality and chance is an open discussion
topic in many disciplines. In particular, ageing, the related
diseases, and longevity are difficult to define as a consequence of
causality, chance or both. Discussing the relevance of these
different factors in the attainment of longevity, the book gathers
contributions on genetic, epigenetic and phenotypic aspects of
centenarians. The "positive biology" approach is applied to clarify
the causes of positive phenotypes, as well as to explain the
biological mechanisms of health and well-being with the aim of
preventing and/or reducing frailty and disability in the elderly.
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