Allopurinol is poorly water soluble drug used in treatment of gout.
Rapid onset of action of allopurinol drug in treatment of gout is
required. Solubility is rate limiting step for this drug. To
enhance the solubility here solid dispersion and crystal
engineering approach was selected and applied. The solubility and
dissolution rate of allopurinol can be enhanced by the use of SDs
of allopurinol with PVPK30. The solubilization effect of PVPK30,
reduction of particle aggregation of the drug, absence of
crystallinity, and alteration of the surface properties of the drug
particles might be responsible for the enhanced solubility and
dissolution rate of allopurinol from its SD. From FTIR
spectroscopy, it was concluded that there was no well defined
interaction between allopurinol and PVPK30, since no new peaks or
shift of peaks could be observed. The absence of an endothermic
peak of allopurinol in the DSC thermo grams of SDs with
PVPK30showed the conversion of allopurinol from crystalline to
amorphous state. It can be concluded that the preparation SDs of
allopurinol with Polymer PVPK30 with ratio (1:2) provides a
promising way to enhance its solubility and dissolution.
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