The testis is composed of seminiferous tubules and interstitial
tissue. The most important component of the interstitial tissue are
the testosterone-producing Leydig cells. The seminiferous tubules
contain the successive generations of germ cells, which can only
exist in the presence of Sertoli cells. Sertoli cells mediate the
effect of testosterone, which is indispensable for the maintenance
of spermatogenesis. Consequently, the function of the Sertoli cells
depends large lyon the function of the Leydig cells, and a local
control mechanism between the two cell systems has been assumed.
Sertoli cells are supposed to interfere with the regulation of
Leydig cell hormone production (Aoki and Fawcett 1978; Sharpe et
al. 1981). Few cell types of the testis have received as much
attention in recent years as have the Sertoli cells. While
comprehensive data had accumulated concerning the differentiation
of germ cells, there was formerly little information available on
the influence of Sertoli cells on this process. Only through
recently developed methods and experimental approaches could their
central role in spermatogene sis be verified. Sertoli cells are the
only somatic cells in the seminiferous tubules. Their origin is
still disputed (for references see Ritzen et al. 1981). They
supposedly stem either from the coelomic epithelium or from
mesenchymal cells of the genital ridges. According to Wartenberg
(1978) they are derived from a gonadal blas tema containing cells
from both the coelomic epithelium and the mesonephros."
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