This book arose from a meeting held at the University of
Washington, Seattle, in July of 1986. The meeting was a satellite
symposium of the XXXth International Congress of Physiological
Sciences which occurred in Vancouver, canada, at that time. 2
Adjustments in the cytoplasmic Ca ] concentration of cells occur in
response to a variety of external signals. These fluctuations are a
cen tral component of one mechanism by which cells adapt their
activities to changes in the external environment and to the
requirements of whole body 2 homeostatic mechanisms. It is now
clear that redistribution of Ca + within 2 intracellular
compartments, as well as changes in the rates of Ca + influx and
extrusion at the whole cell level, occur during signal-dependent 2
changes in the cytoplasmic Ca + concentration. In summarizing
current research in this area, this volume considers first the
properties of indi vidual cation transporting activities located in
various cell membranes. It then moves to the cellular level, where
the consequence of individual transporting activities acting in
concert is examined. l D.phasis is also 2 p1 aced on pa tho1 ogica1
conditions which resu1 t in loss of cell Ca + regu1 a tion as a
part of the disease process. We hope that this approach will help
the reader to integrate developments in this large and rapdi1y
changing fie1 d."
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