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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Cell Migration in Inflammation and Immunity - Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2003)
Loot Price: R3,016
Discovery Miles 30 160
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Cell Migration in Inflammation and Immunity - Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2003)
Series: Methods in Molecular Biology, 239
Expected to ship within 10 - 15 working days
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Chemokines and their receptors play a central role in the
pathogenesis of numerous, perhaps all, acute and chronic
inflammatory diseases. About 50 distinct chemokines produced by a
variety cell types and tissues either c- stitutively or in response
to inflammatory stimuli are involved in a plethora of biological
processes. These small secreted proteins exert their exquisitely
variegated functions upon binding to a family of
seven-transmembrane spanning G-protein coupled receptors (GPCRs)
composed of almost 20 distinct entities. The biological activities
of chemokines range from the control of leukocyte trafficking in
basal and inflammatory conditions to the regulation of hema-
poiesis, angiogenesis, tissue architecture, and organogenesis. The
basis for such diversified activities rests, on one hand, upon the
ubiquitous nature of chemokine production and chemokine receptor
expression. Virtually every cell type can produce chemokines and
expresses a unique combination of chemokine receptors. On the other
hand, chemokine receptors make use of a flexible and complex
network of intracellular signaling machineries that can regulate a
variety of cellular functions ranging from cell migration, growth,
and differentiation to death. As knowledge of the size of chemokine
and chemokine receptor families rapidly reaches completeness, much
is still to be uncovered in terms of fu- tional architecture of the
chemokine system. The disparity between the large number of
chemokines and that smaller number of receptors is balanced by the
promiscuity in ligand-receptor interactions, with multiple
chemokines binding to the same receptor and several chemokines
binding to more than one receptor.
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